Detailed information NTG0818658

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: QAY62_RS10055
• Genome accession: NZ_CP123097
• Coordinates: 2054183..2055532 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain MRSA-ATCC43300
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2054183..2075548	2054183..2055532	within	0

Gene organization within MGE regions

Location: 2054183..2075548

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY62_RS10055 (QAY62_10040)	ccrA	2054183..2055532 (+)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene
QAY62_RS10060 (QAY62_10045)	ccrB	2055554..2057182 (+)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
QAY62_RS10065 (QAY62_10050)	-	2057700..2058050 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
QAY62_RS10070 (QAY62_10055)	-	2058137..2058448 (+)	312	WP_000700853.1	DUF960 family protein	-
QAY62_RS10075 (QAY62_10060)	-	2058466..2058972 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
QAY62_RS10080 (QAY62_10065)	-	2058993..2059310 (+)	318	WP_000659050.1	JAB domain-containing protein	-
QAY62_RS10085 (QAY62_10070)	-	2059429..2060514 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
QAY62_RS10090 (QAY62_10075)	-	2060511..2062403 (+)	1893	WP_001557544.1	site-specific integrase	-
QAY62_RS10095 (QAY62_10080)	-	2062410..2062787 (+)	378	WP_000361059.1	DUF6262 family protein	-
QAY62_RS10100 (QAY62_10085)	-	2062938..2063720 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
QAY62_RS10105 (QAY62_10090)	erm(A)	2063846..2064577 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
QAY62_RS10110	-	2064660..2064719 (-)	60	WP_010959190.1	erythromycin resistance leader peptide	-
QAY62_RS10115 (QAY62_10095)	-	2065111..2065773 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
QAY62_RS10120 (QAY62_10100)	-	2066118..2066756 (-)	639	Protein_1959	sulfite exporter TauE/SafE family protein	-
QAY62_RS10125 (QAY62_10105)	cstR	2066756..2067016 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
QAY62_RS10130 (QAY62_10110)	-	2067152..2068216 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
QAY62_RS10135 (QAY62_10115)	cstB	2068249..2069583 (+)	1335	Protein_1962	persulfide dioxygenase-sulfurtransferase CstB	-
QAY62_RS10140 (QAY62_10120)	-	2069697..2070806 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
QAY62_RS10145 (QAY62_10125)	psm-mec	2071161..2071229 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
QAY62_RS10150 (QAY62_10130)	mecI	2071314..2071685 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
QAY62_RS10155 (QAY62_10135)	mecR1	2071685..2073442 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
QAY62_RS10160 (QAY62_10140)	mecA	2073539..2075548 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=818658 QAY62_RS10055 WP_000815646.1 2054183..2055532(+) (ccrA) [Staphylococcus aureus strain MRSA-ATCC43300]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=818658 QAY62_RS10055 WP_000815646.1 2054183..2055532(+) (ccrA) [Staphylococcus aureus strain MRSA-ATCC43300]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748