Detailed information NTG0818237

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAO26_RS00465
• Genome accession: NZ_CP123077
• Coordinates: 82125..83168 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SW-MRSA60
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77125..88168

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAO26_RS00435 (QAO26_00430)	-	77551..77661 (+)	111	WP_001790257.1	hypothetical protein	-
QAO26_RS00440 (QAO26_00435)	-	77690..78103 (+)	414	WP_001557448.1	hypothetical protein	-
QAO26_RS00445 (QAO26_00440)	-	78534..79520 (-)	987	WP_000999717.1	FUSC family protein	-
QAO26_RS00450 (QAO26_00445)	map	80051..80809 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAO26_RS00455 (QAO26_00450)	-	81026..81412 (+)	387	WP_001110179.1	hypothetical protein	-
QAO26_RS00460 (QAO26_00455)	liaF	81427..82128 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAO26_RS00465 (QAO26_00460)	vraS	82125..83168 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAO26_RS00470 (QAO26_00465)	vraR	83158..83787 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAO26_RS00475 (QAO26_00470)	-	83900..85117 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
QAO26_RS00480 (QAO26_00475)	-	85395..85670 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QAO26_RS00485 (QAO26_00480)	-	85677..86141 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAO26_RS00490 (QAO26_00485)	-	86288..86488 (+)	201	WP_078066076.1	DUF1128 domain-containing protein	-
QAO26_RS00495 (QAO26_00490)	-	86491..87747 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=818237 QAO26_RS00465 WP_001017131.1 82125..83168(+) (vraS) [Staphylococcus aureus strain SW-MRSA60]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=818237 QAO26_RS00465 WP_001017131.1 82125..83168(+) (vraS) [Staphylococcus aureus strain SW-MRSA60]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1