Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   R3H61_RS02620 Genome accession   NZ_CP136951
Coordinates   514470..515111 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain Spyo09     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 509470..520111
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H61_RS02600 (R3H61_02600) - 510026..510766 (+) 741 WP_115233413.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  R3H61_RS02605 (R3H61_02605) pknB 510763..512661 (+) 1899 WP_012560855.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  R3H61_RS02610 (R3H61_02610) liaF 512784..513476 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  R3H61_RS02615 (R3H61_02615) - 513473..514477 (+) 1005 WP_002991890.1 sensor histidine kinase -
  R3H61_RS02620 (R3H61_02620) vraR 514470..515111 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  R3H61_RS02625 (R3H61_02625) - 515148..516548 (+) 1401 WP_023079249.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  R3H61_RS02630 (R3H61_02630) - 516548..516925 (+) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  R3H61_RS02635 (R3H61_02635) cysK 516943..517884 (-) 942 WP_011888673.1 cysteine synthase A -
  R3H61_RS02640 (R3H61_02640) - 518012..518644 (-) 633 WP_032465870.1 YigZ family protein -
  R3H61_RS02645 (R3H61_02645) comFA/cflA 518700..520025 (+) 1326 WP_032465157.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=816625 R3H61_RS02620 WP_002983671.1 514470..515111(+) (vraR) [Streptococcus pyogenes strain Spyo09]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=816625 R3H61_RS02620 WP_002983671.1 514470..515111(+) (vraR) [Streptococcus pyogenes strain Spyo09]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385