Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   R8522_RS11105 Genome accession   NZ_AP026916
Coordinates   2157324..2158622 (+) Length   432 a.a.
NCBI ID   WP_061372803.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700006     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2152324..2163622
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8522_RS11090 (PC0006_21970) - 2152641..2154044 (-) 1404 WP_000388558.1 rhamnulokinase family protein -
  R8522_RS11095 (PC0006_21980) - 2154220..2154993 (+) 774 WP_000588548.1 DeoR/GlpR family DNA-binding transcription regulator -
  R8522_RS11100 (PC0006_21990) - 2156358..2157311 (+) 954 WP_001155321.1 IS30-like element ISSpn8 family transposase -
  R8522_RS11105 comD/comD2 2157324..2158622 (+) 1299 WP_061372803.1 competence system sensor histidine kinase ComD Regulator
  R8522_RS11110 (PC0006_22010) comE 2158619..2159371 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R8522_RS11125 (PC0006_22020) - 2159613..2160155 (-) 543 WP_050123485.1 TetR/AcrR family transcriptional regulator -
  R8522_RS11130 - 2160334..2161937 (+) 1604 Protein_2160 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 50600.01 Da        Isoelectric Point: 7.5553

>NTDB_id=81656 R8522_RS11105 WP_061372803.1 2157324..2158622(+) (comD/comD2) [Streptococcus pneumoniae strain PZ900700006]
MWDFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQYERDRGLFLS
LLLSLLYESTHNFLSVIFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKKVFFALLLLH
IVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLYNEIRGFRHD
YAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEFTLEVKDTIT
KLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFSLGFSTKGRNRGVGLNNV
KELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=81656 R8522_RS11105 WP_061372803.1 2157324..2158622(+) (comD/comD2) [Streptococcus pneumoniae strain PZ900700006]
ATTTGGGATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCGAATAAATAGAAAAGAATTATACGTTTT
TGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTCTATATTTAGATAAAATAGGGATTGAAA
GATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTATGAGAGGGATAGAGGACTATTCCTAAGT
TTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAATTTTCTCCTCTATAACAGGAGATAATTTTGT
TTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTGTTACATTAAAAATCATTTACTATTTCC
ATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAAGTATTTTTTGCTTTACTATTGCTACAT
ATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTTTGGAAGTATTTTGTCATCTATTGTCTT
TATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGGAGAAAGAGATTGCTTTGAAGCAGAAGA
AATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTATAATGAAATCCGTGGTTTTCGACATGAT
TATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACAGGAAATTGACAGAATTTACAATGAAGT
TTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATTTGAACAACATAGAAGACTCAGCTTTAC
GAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTTACACTGGAAGTAAAAGATACGATTACC
AAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAATAATGCTGTCGAAGGATCGGCTGATAG
CTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTATTGTGATTCAGAATTCATGTAAAATGA
CGATGACTCCTTCAGGAGATCTATTTTCCTTAGGATTCTCCACTAAGGGAAGAAATCGCGGAGTCGGATTAAATAATGTG
AAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGGCAGTACATTTAGACAAATCATTAGATT
TAAGAGGGAATTTGAATGA

Domains

Predicted by InterProScan.

GHKL domain (HATPase_c_5)

(325-425)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.767

99.306

0.991
  comD/comD1 Streptococcus pneumoniae Rx1

96.737

99.306

0.961
  comD/comD1 Streptococcus pneumoniae D39

96.737

99.306

0.961
  comD/comD1 Streptococcus pneumoniae R6

96.737

99.306

0.961
  comD Streptococcus mitis SK321

92.774

99.306

0.921
  comD Streptococcus mitis NCTC 12261

87.822

98.843

0.868
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

86.574

0.431
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

87.037

0.431

Multiple sequence alignment