Detailed information NTG0816487

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: R3H37_RS08655
• Genome accession: NZ_CP136948
• Coordinates: 1764455..1767010 (-)
• Length: 851 a.a.
• NCBI ID: WP_023609835.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Spyo01
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1759455..1772010

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R3H37_RS08635 (R3H37_08640)	-	1759945..1760505 (-)	561	WP_011018314.1	DNA-3-methyladenine glycosylase I	-
R3H37_RS08640 (R3H37_08645)	ruvA	1760515..1761111 (-)	597	WP_011285268.1	Holliday junction branch migration protein RuvA	Machinery gene
R3H37_RS08645 (R3H37_08650)	-	1761113..1762333 (-)	1221	WP_053308678.1	MDR family MFS transporter	-
R3H37_RS08650 (R3H37_08655)	hexB	1762344..1764326 (-)	1983	WP_053308679.1	DNA mismatch repair endonuclease MutL	Machinery gene
R3H37_RS08655 (R3H37_08660)	hexA	1764455..1767010 (-)	2556	WP_023609835.1	DNA mismatch repair protein MutS	Machinery gene
R3H37_RS09040	-	1766997..1767352 (-)	356	Protein_1649	YlbF family regulator	-
R3H37_RS08665 (R3H37_08670)	argR	1767349..1767786 (-)	438	WP_002982171.1	arginine repressor	-
R3H37_RS08670 (R3H37_08675)	argS	1768077..1769768 (+)	1692	WP_330554653.1	arginine--tRNA ligase	-
R3H37_RS08675 (R3H37_08680)	-	1769856..1770164 (+)	309	WP_012561077.1	bacteriocin immunity protein	-
R3H37_RS08680 (R3H37_08685)	-	1770191..1771063 (-)	873	WP_002982164.1	YitT family protein	-
R3H37_RS08685 (R3H37_08690)	-	1771106..1771984 (-)	879	WP_002991372.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95532.08 Da
• Isoelectric Point: 4.9823

>NTDB_id=816487 R3H37_RS08655 WP_023609835.1 1764455..1767010(-) (hexA) [Streptococcus pyogenes strain Spyo01]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFDSPCVDKIVNDIDNLPELEYLIRTAIDP
DAPATISEGSIIRNGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTNSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPPQV
ESSSAVRQGQLSLFGDDEKAHEIRQALEAIDVMNMTPFQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=816487 R3H37_RS08655 WP_023609835.1 1764455..1767010(-) (hexA) [Streptococcus pyogenes strain Spyo01]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCTATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCA
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTCTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCTCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTGACA
GTCCTTGTGTTGACAAAATTGTCAATGATATTGACAATTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGAAGTATTATCCGCAATGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTAAT
GCGAGAGGGGACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGTGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAATTTTGGCAACGGTAGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCCGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGATTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTTGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATGTCAGTCCCTCCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGATGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGTTTCAAGCAATGACAACTCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.445	100	0.714
mutS	Pseudomonas stutzeri strain ATCC 17587	37.076	100	0.373