Detailed information NTG0815904

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAY84_RS09860
• Genome accession: NZ_CP122486
• Coordinates: 2009486..2010529 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IT-MSSA48
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2004486..2015529

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY84_RS09830 (QAY84_09835)	-	2004907..2006163 (-)	1257	WP_001793983.1	aminopeptidase	-
QAY84_RS09835 (QAY84_09840)	-	2006166..2006366 (-)	201	WP_000180460.1	DUF1128 family protein	-
QAY84_RS09840 (QAY84_09845)	-	2006513..2006977 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
QAY84_RS09845 (QAY84_09850)	-	2006984..2007259 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
QAY84_RS09850 (QAY84_09855)	-	2007537..2008754 (+)	1218	WP_411906488.1	YihY/virulence factor BrkB family protein	-
QAY84_RS09855 (QAY84_09860)	vraR	2008867..2009496 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAY84_RS09860 (QAY84_09865)	vraS	2009486..2010529 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAY84_RS09865 (QAY84_09870)	liaF	2010526..2011227 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAY84_RS09870 (QAY84_09875)	-	2011242..2011628 (-)	387	WP_001110178.1	hypothetical protein	-
QAY84_RS09875 (QAY84_09880)	map	2011845..2012603 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAY84_RS09880 (QAY84_09885)	-	2013303..2014289 (+)	987	WP_001014423.1	FUSC family protein	-
QAY84_RS09885 (QAY84_09890)	-	2014478..2014891 (-)	414	WP_001643743.1	hypothetical protein	-
QAY84_RS09890 (QAY84_09895)	-	2014920..2015030 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=815904 QAY84_RS09860 WP_001017131.1 2009486..2010529(-) (vraS) [Staphylococcus aureus strain IT-MSSA48]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=815904 QAY84_RS09860 WP_001017131.1 2009486..2010529(-) (vraS) [Staphylococcus aureus strain IT-MSSA48]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1