Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   R8522_RS01970 Genome accession   NZ_AP026916
Coordinates   377953..378585 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain PZ900700006     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 372953..383585
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8522_RS01945 (PC0006_03960) mvaD 373231..374184 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  R8522_RS01950 (PC0006_03970) - 374171..375178 (+) 1008 WP_000562379.1 phosphomevalonate kinase -
  R8522_RS01955 (PC0006_03980) fni 375162..376172 (+) 1011 WP_000210611.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  R8522_RS01960 (PC0006_03990) liaF 376249..376947 (+) 699 WP_001224632.1 cell wall-active antibiotics response protein LiaF -
  R8522_RS01965 (PC0006_04000) - 376944..377939 (+) 996 WP_000743663.1 sensor histidine kinase -
  R8522_RS01970 (PC0006_04010) vraR 377953..378585 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  R8522_RS01975 - 378661..379355 (+) 695 Protein_388 DNA alkylation repair protein -
  R8522_RS01980 (PC0006_04040) - 379505..379744 (+) 240 WP_000754502.1 hypothetical protein -
  R8522_RS01985 (PC0006_04060) cbpG 379825..380645 (+) 821 Protein_390 choline-binding protein CbpG -
  R8522_RS01990 (PC0006_04070) cbpF 380664..381686 (+) 1023 WP_054367220.1 choline-binding protein CbpF -
  R8522_RS01995 - 381814..382960 (-) 1147 Protein_392 IS3 family transposase -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=81568 R8522_RS01970 WP_000698434.1 377953..378585(+) (vraR) [Streptococcus pneumoniae strain PZ900700006]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=81568 R8522_RS01970 WP_000698434.1 377953..378585(+) (vraR) [Streptococcus pneumoniae strain PZ900700006]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment