Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGE/cglE   Type   Machinery gene
Locus tag   R8474_RS09610 Genome accession   NZ_AP026914
Coordinates   1882352..1882654 (-) Length   100 a.a.
NCBI ID   WP_000413382.1    Uniprot ID   C0HMA8
Organism   Streptococcus pneumoniae strain PZ900700003     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1877352..1887654
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8474_RS09575 (PC0003_18710) rnpA 1878033..1878404 (-) 372 WP_000739244.1 ribonuclease P protein component -
  R8474_RS09580 - 1878421..1878552 (-) 132 WP_000768904.1 hypothetical protein -
  R8474_RS09585 (PC0003_18720) - 1878553..1879743 (-) 1191 WP_000167769.1 acetate kinase -
  R8474_RS09590 (PC0003_18730) comGH 1879794..1880747 (-) 954 WP_000345127.1 class I SAM-dependent methyltransferase Machinery gene
  R8474_RS09595 - 1880808..1881402 (-) 595 Protein_1869 class I SAM-dependent methyltransferase -
  R8474_RS09600 (PC0003_18760) comGG/cglG 1881558..1881950 (-) 393 WP_001818028.1 competence type IV pilus minor pilin ComGG Machinery gene
  R8474_RS09605 comGF/cglF 1881928..1882389 (-) 462 WP_000250539.1 competence type IV pilus minor pilin ComGF Machinery gene
  R8474_RS09610 (PC0003_18780) comGE/cglE 1882352..1882654 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  R8474_RS09615 (PC0003_18790) comGD/cglD 1882617..1883021 (-) 405 WP_000588030.1 competence type IV pilus minor pilin ComGD Machinery gene
  R8474_RS09620 (PC0003_18800) comGC/cglC 1883014..1883340 (-) 327 WP_000738625.1 competence type IV pilus major pilin ComGC Machinery gene
  R8474_RS09625 (PC0003_18810) comGB/cglB 1883342..1884358 (-) 1017 WP_074017570.1 competence type IV pilus assembly protein ComGB Machinery gene
  R8474_RS09630 (PC0003_18820) comGA/cglA/cilD 1884306..1885247 (-) 942 WP_000249549.1 competence type IV pilus ATPase ComGA Machinery gene
  R8474_RS09635 (PC0003_18830) - 1885323..1885688 (-) 366 WP_000286415.1 DUF1033 family protein -
  R8474_RS09640 (PC0003_18840) - 1885839..1886897 (-) 1059 WP_000649466.1 zinc-dependent alcohol dehydrogenase family protein -

Sequence

Protein


Download         Length: 100 a.a.        Molecular weight: 11108.08 Da        Isoelectric Point: 9.7273

>NTDB_id=81415 R8474_RS09610 WP_000413382.1 1882352..1882654(-) (comGE/cglE) [Streptococcus pneumoniae strain PZ900700003]
MEKLNALRKQKIRAVILLEAVVALAIFASIATLLLGQIQKNRQEEAKILQKEEVLRVAKMALQTGQNQVSINGVEIQVFS
SEKGLEVYHGSEQLLAIKEP

Nucleotide


Download         Length: 303 bp        

>NTDB_id=81415 R8474_RS09610 WP_000413382.1 1882352..1882654(-) (comGE/cglE) [Streptococcus pneumoniae strain PZ900700003]
ATGGAAAAATTAAACGCATTAAGGAAACAAAAAATTAGGGCAGTGATTTTACTGGAAGCAGTAGTCGCTCTAGCTATCTT
TGCCAGCATTGCGACCCTCCTTTTGGGACAAATTCAAAAAAATAGGCAAGAGGAAGCAAAAATCTTGCAAAAGGAAGAAG
TCTTGAGGGTAGCTAAGATGGCCCTGCAGACGGGGCAAAATCAGGTAAGCATCAACGGAGTTGAGATTCAGGTATTTTCT
AGTGAAAAAGGATTGGAGGTCTACCATGGTTCAGAACAGTTGTTGGCAATCAAAGAGCCATAA

Domains

Predicted by InterProScan.

Type II secretory pathway pseudopilin (ComGE)

(16-97)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C0HMA8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGE/cglE Streptococcus pneumoniae Rx1

100

100

1
  comGE/cglE Streptococcus pneumoniae D39

100

100

1
  comGE/cglE Streptococcus pneumoniae R6

100

100

1
  comGE/cglE Streptococcus pneumoniae TIGR4

100

100

1
  comGE/cglE Streptococcus mitis NCTC 12261

98

100

0.98
  comGE/cglE Streptococcus mitis SK321

98

100

0.98
  comGE Streptococcus mutans UA140

44.444

90

0.4
  comGE Streptococcus mutans UA159

44.444

90

0.4

Multiple sequence alignment