Detailed information NTG0811444

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: P8632_RS00180
• Genome accession: NZ_CP121263
• Coordinates: 40458..42086 (-)
• Length: 542 a.a.
• NCBI ID: WP_070653754.1
• Uniprot ID: -
• Organism: Staphylococcus hominis strain FSEL1
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	40965..66064	40458..42086	flank	-1121

Gene organization within MGE regions

Location: 40458..66064

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P8632_RS00180 (P8632_00180)	ccrB	40458..42086 (-)	1629	WP_070653754.1	cassette chromosome recombinase CcrB	Machinery gene
P8632_RS00185 (P8632_00185)	ccrA	42120..43457 (-)	1338	WP_326514989.1	cassette chromosome recombinase CcrA	Machinery gene
P8632_RS00190 (P8632_00190)	cch1	43644..45413 (-)	1770	WP_411912924.1	cassette chromosome replicative helicase	-
P8632_RS00195 (P8632_00195)	ssb	45413..45703 (-)	291	WP_108703126.1	cassette chromosome ssDNA-binding protein	-
P8632_RS00200 (P8632_00200)	-	45874..46947 (+)	1074	WP_023604763.1	hypothetical protein	-
P8632_RS00205 (P8632_00205)	-	47041..48981 (+)	1941	WP_023604764.1	ATP-dependent DNA helicase	-
P8632_RS00210 (P8632_00210)	-	49082..49546 (+)	465	WP_023604765.1	hypothetical protein	-
P8632_RS00215 (P8632_00215)	-	49640..49789 (-)	150	WP_154391900.1	hypothetical protein	-
P8632_RS00220 (P8632_00220)	-	50132..50770 (+)	639	WP_001033157.1	fusidic acid resistance EF-G-binding protein FusC	-
P8632_RS00225 (P8632_00225)	-	50927..51709 (+)	783	WP_070813266.1	hypothetical protein	-
P8632_RS00230 (P8632_00230)	-	52136..52546 (+)	411	WP_039984130.1	DUF5776 domain-containing protein	-
P8632_RS00235 (P8632_00235)	mntC	52627..53557 (-)	931	Protein_44	manganese ABC transporter substrate-binding lipoprotein MntC	-
P8632_RS00240 (P8632_00240)	-	53554..54390 (-)	837	WP_326514990.1	metal ABC transporter permease	-
P8632_RS00245 (P8632_00245)	-	54383..55126 (-)	744	WP_002449195.1	metal ABC transporter ATP-binding protein	-
P8632_RS00250 (P8632_00250)	-	55385..55495 (+)	111	Protein_47	GTP-binding protein	-
P8632_RS00255 (P8632_00255)	-	55885..56028 (+)	144	WP_002449224.1	SAS049 family protein	-
P8632_RS00260 (P8632_00260)	-	56143..57268 (-)	1126	Protein_49	IS3 family transposase	-
P8632_RS00265 (P8632_00265)	-	57454..57882 (-)	429	WP_002490405.1	VOC family protein	-
P8632_RS00270 (P8632_00270)	-	57962..58891 (+)	930	WP_048665469.1	helix-turn-helix transcriptional regulator	-
P8632_RS00275 (P8632_00275)	-	58991..60979 (+)	1989	WP_070813302.1	hypothetical protein	-
P8632_RS00280 (P8632_00280)	-	61174..62283 (+)	1110	WP_070813301.1	DNA polymerase	-
P8632_RS00285 (P8632_00285)	-	62276..62647 (+)	372	WP_070813300.1	hypothetical protein	-
P8632_RS00290 (P8632_00290)	-	62644..64287 (+)	1644	WP_070813299.1	DUF5906 domain-containing protein	-

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62463.58 Da
• Isoelectric Point: 9.5934

>NTDB_id=811444 P8632_RS00180 WP_070653754.1 40458..42086(-) (ccrB) [Staphylococcus hominis strain FSEL1]
MDKMKKKLVGGYIRVSTERQVEGYSIEGQITQIEQYCQFNGYELVDIYADRGISGKSMNRPELQRMLNDAKNGKLDCVMV
YKTNRLARNTSDLLTIVEELHRQNVEFFSLSERMEVKNSTGKLMLQILASFSEFERNTILENIYTGQRQRALEGYYQGNL
PLGYNNIPDNKKELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGNPFSISAVTYILSNPFYIGKIQFAKY
KDWNDKRRKGLNDNPVIAEGKHTPIISQALWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKLLKQLVEKVNERSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILNYQDELNQINNQIHQLEQDKQAEATHYDADMIANILQTIFKDIDKLEKSQLKS
LYLTVIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLLSTSSLFLPQTLYITIE

Nucleotide

• Length: 1629 bp

>NTDB_id=811444 P8632_RS00180 WP_070653754.1 40458..42086(-) (ccrB) [Staphylococcus hominis strain FSEL1]
ATGGATAAAATGAAGAAAAAGCTTGTAGGAGGCTACATTCGCGTATCCACAGAGAGACAAGTAGAGGGTTATAGCATCGA
GGGACAAATTACACAAATAGAGCAATATTGCCAATTTAACGGCTATGAACTCGTTGATATATATGCAGATCGGGGTATAT
CAGGAAAATCTATGAATCGTCCTGAATTACAGCGCATGTTAAATGATGCTAAAAATGGAAAATTAGACTGTGTTATGGTT
TATAAAACAAATCGTTTGGCACGTAATACTTCCGATTTACTTACAATCGTCGAAGAACTTCATCGTCAAAATGTTGAATT
TTTTAGCTTGTCTGAACGCATGGAAGTCAAAAATTCAACAGGTAAGTTAATGCTCCAGATACTTGCAAGTTTTTCCGAAT
TTGAAAGAAATACAATTTTAGAGAACATTTACACCGGACAACGTCAAAGAGCTTTAGAGGGCTATTATCAAGGCAATCTT
CCATTAGGATATAATAACATACCTGATAATAAAAAAGAATTAATGATTAATCAACATGAAGCTAACATCGTTAAATATAT
CTTTGAATCTTACGCCAAAGGTCATGGTTATCGTAAAATAGCCAATGCACTCAATCACAAAGGCTATGTGACTAAAAAAG
GCAATCCATTTAGTATTTCAGCTGTTACTTATATTCTCTCAAACCCATTCTATATTGGTAAAATTCAATTCGCGAAATAC
AAAGATTGGAATGATAAACGACGTAAAGGCTTGAATGATAATCCAGTGATCGCTGAAGGCAAACACACACCTATTATTAG
TCAAGCTTTATGGGATAAAGTGCAATTCAAACGCCAAGAGAGTCGTAAGAAACCACAAGTTCATGGTAAAGGGACCAATC
TACTTACTGGGATTGTAAAGTGCCCAAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACCAACACTTTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTATTCATGTAGCAATTTTAGAAACAAAGGTTCTAAAGTATGTTCAGCCAATTCTGTTAG
AGCAGATGTATTAGAAAAATATGTTATGGATCAGATATTAGAAATTATTAAAAGTAAAAAGTTATTGAAACAATTAGTCG
AAAAAGTAAATGAAAGAAGTCAAATAGACGTCTCTTCTTTGAATCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCCAAAATGCATACACTAACGAAAACCATCGAAGACTCCCCTGACTTAGATAGCGTATTGAAACCCACAATACT
TAACTATCAAGATGAATTGAATCAAATAAATAATCAAATCCATCAACTAGAACAAGATAAACAAGCGGAAGCTACACATT
ATGATGCTGATATGATTGCCAACATACTACAAACAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAGTCATCGATCGTATTGACATAAGAAAAGATGAGCATCATAAGAAACAATTTTATGTCACACTCAAATT
GAATAATGATATTATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCTTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA

Domains

Predicted by InterproScan.

• Ogr/Delta-like zinc finger (Ogr_Delta) (300-355)

• Recombinase (Recombinase) (179-280)

• Resolvase, N terminal domain (Resolvase) (11-154)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	73.985	100	0.74