Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   P8632_RS00185 Genome accession   NZ_CP121263
Coordinates   42120..43457 (-) Length   445 a.a.
NCBI ID   WP_326514989.1    Uniprot ID   -
Organism   Staphylococcus hominis strain FSEL1     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 40965..66064 42120..43457 within 0


Gene organization within MGE regions


Location: 40965..66064
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8632_RS00185 (P8632_00185) ccrA 42120..43457 (-) 1338 WP_326514989.1 cassette chromosome recombinase CcrA Machinery gene
  P8632_RS00190 (P8632_00190) cch1 43644..45413 (-) 1770 WP_411912924.1 cassette chromosome replicative helicase -
  P8632_RS00195 (P8632_00195) ssb 45413..45703 (-) 291 WP_108703126.1 cassette chromosome ssDNA-binding protein -
  P8632_RS00200 (P8632_00200) - 45874..46947 (+) 1074 WP_023604763.1 hypothetical protein -
  P8632_RS00205 (P8632_00205) - 47041..48981 (+) 1941 WP_023604764.1 ATP-dependent DNA helicase -
  P8632_RS00210 (P8632_00210) - 49082..49546 (+) 465 WP_023604765.1 hypothetical protein -
  P8632_RS00215 (P8632_00215) - 49640..49789 (-) 150 WP_154391900.1 hypothetical protein -
  P8632_RS00220 (P8632_00220) - 50132..50770 (+) 639 WP_001033157.1 fusidic acid resistance EF-G-binding protein FusC -
  P8632_RS00225 (P8632_00225) - 50927..51709 (+) 783 WP_070813266.1 hypothetical protein -
  P8632_RS00230 (P8632_00230) - 52136..52546 (+) 411 WP_039984130.1 DUF5776 domain-containing protein -
  P8632_RS00235 (P8632_00235) mntC 52627..53557 (-) 931 Protein_44 manganese ABC transporter substrate-binding lipoprotein MntC -
  P8632_RS00240 (P8632_00240) - 53554..54390 (-) 837 WP_326514990.1 metal ABC transporter permease -
  P8632_RS00245 (P8632_00245) - 54383..55126 (-) 744 WP_002449195.1 metal ABC transporter ATP-binding protein -
  P8632_RS00250 (P8632_00250) - 55385..55495 (+) 111 Protein_47 GTP-binding protein -
  P8632_RS00255 (P8632_00255) - 55885..56028 (+) 144 WP_002449224.1 SAS049 family protein -
  P8632_RS00260 (P8632_00260) - 56143..57268 (-) 1126 Protein_49 IS3 family transposase -
  P8632_RS00265 (P8632_00265) - 57454..57882 (-) 429 WP_002490405.1 VOC family protein -
  P8632_RS00270 (P8632_00270) - 57962..58891 (+) 930 WP_048665469.1 helix-turn-helix transcriptional regulator -
  P8632_RS00275 (P8632_00275) - 58991..60979 (+) 1989 WP_070813302.1 hypothetical protein -
  P8632_RS00280 (P8632_00280) - 61174..62283 (+) 1110 WP_070813301.1 DNA polymerase -
  P8632_RS00285 (P8632_00285) - 62276..62647 (+) 372 WP_070813300.1 hypothetical protein -
  P8632_RS00290 (P8632_00290) - 62644..64287 (+) 1644 WP_070813299.1 DUF5906 domain-containing protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 52088.78 Da        Isoelectric Point: 10.0581

>NTDB_id=811445 P8632_RS00185 WP_326514989.1 42120..43457(-) (ccrA) [Staphylococcus hominis strain FSEL1]
MVEAIGYVRQSTLKQQSLATQQSLILNTAKQYGWPNVTFYDDKKSGRHTKRSGYQKMVEMITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHVTIISVNDGYFDLSKEFDRFRLNILMSLAEMESNNISEQTRNGIKEKAKQGKMITTHAPFGYQYH
NGTFTIDTVKAPTIKAVFNYYLQGYGYKKIAQYLEADDNFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKPDHSLRYYVCPQNMNNARFVCEFKGINAQELETSVLAT
CQDFFQNQQLYSKINHTIQQRLKRQRDIETKTTLNHEQLIEKLAQGKIDAETFREQTQSLHQRSKPISSISAHQIRKAFQ
NIIQQRFTLNMLYPYIDEINISKNKSLAGIYFKNEPLNIVKQTMK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=811445 P8632_RS00185 WP_326514989.1 42120..43457(-) (ccrA) [Staphylococcus hominis strain FSEL1]
ATGGTAGAAGCCATTGGTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAGCAATCTCTGATTTTAAA
TACTGCTAAGCAATATGGATGGCCTAATGTAACATTTTATGATGATAAGAAAAGCGGTCGACATACGAAACGGTCAGGTT
ATCAAAAAATGGTAGAAATGATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAATCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGCAAAAAGCATCACGTCACAATCATCAGTGTGAATGATGGTTATTTTGA
CTTATCTAAGGAATTTGACCGCTTTCGCCTAAACATACTTATGAGTCTAGCTGAAATGGAGTCTAATAATATCAGTGAAC
AAACACGAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAAATGATTACAACACATGCACCCTTTGGGTATCAATATCAT
AATGGTACTTTCACGATAGACACAGTAAAAGCACCAACAATAAAAGCTGTATTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATATTTAGAAGCTGATGATAACTTCATTAATCGCAAGCCTTATCAAGTGCGTAATATTATCCTCA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACAAGTAAAACGTAAGCCGTCAGAAAATCAACTCAAACAAAAAATCAA
ATGTCCCTATTGTCATTCGACACTCACAAACATGACTGTCCGAAAACCAGATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAACGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TATAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACGATCAAAACCTATATCATCAATCAGTGCGCATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAACAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATATTTCTAAAAATAAAAGCCT
CGCTGGCATCTATTTCAAAAACGAACCACTGAATATTGTAAAGCAGACTATGAAATGA

Domains

Predicted by InterproScan.

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(170-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

84.045

100

0.84
  ccrA Staphylococcus aureus N315

65.618

100

0.656