Detailed information NTG0807447

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: P4B11_RS00465
• Genome accession: NZ_CP120652
• Coordinates: 81646..82689 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 205M
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76646..87689

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P4B11_RS00435 (P4B11_00430)	-	77072..77182 (+)	111	WP_001790257.1	hypothetical protein	-
P4B11_RS00440 (P4B11_00435)	-	77211..77624 (+)	414	WP_001557448.1	hypothetical protein	-
P4B11_RS00445 (P4B11_00440)	-	78055..79041 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
P4B11_RS00450 (P4B11_00445)	map	79572..80330 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
P4B11_RS00455 (P4B11_00450)	-	80547..80933 (+)	387	WP_001110179.1	hypothetical protein	-
P4B11_RS00460 (P4B11_00455)	liaF	80948..81649 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
P4B11_RS00465 (P4B11_00460)	vraS	81646..82689 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
P4B11_RS00470 (P4B11_00465)	vraR	82679..83308 (+)	630	WP_404968744.1	two-component system response regulator VraR	Regulator
P4B11_RS00475 (P4B11_00470)	-	83421..84638 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
P4B11_RS00480 (P4B11_00475)	-	84916..85191 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
P4B11_RS00485 (P4B11_00480)	-	85198..85662 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
P4B11_RS00490 (P4B11_00485)	-	85809..86009 (+)	201	WP_000180460.1	DUF1128 family protein	-
P4B11_RS00495 (P4B11_00490)	-	86012..87268 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=807447 P4B11_RS00465 WP_001017131.1 81646..82689(+) (vraS) [Staphylococcus aureus strain 205M]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=807447 P4B11_RS00465 WP_001017131.1 81646..82689(+) (vraS) [Staphylococcus aureus strain 205M]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGATGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1