Detailed information NTG0800006

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: P1K34_RS02250
• Genome accession: NZ_CP119598
• Coordinates: 430441..431793 (+)
• Length: 450 a.a.
• NCBI ID: WP_111676637.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 1042
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 425441..436793

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P1K34_RS02225 (P1K34_02225)	-	425590..425739 (+)	150	WP_002990686.1	hypothetical protein	-
P1K34_RS02230 (P1K34_02230)	-	426134..427282 (+)	1149	WP_032460078.1	acetyl-CoA C-acyltransferase	-
P1K34_RS02235 (P1K34_02235)	-	427239..428486 (+)	1248	WP_011284594.1	AMP-binding protein	-
P1K34_RS02240 (P1K34_02240)	-	428542..429576 (+)	1035	WP_014407394.1	DUF3114 domain-containing protein	-
P1K34_RS02245 (P1K34_02245)	vicR	429738..430448 (+)	711	WP_002985645.1	response regulator YycF	Regulator
P1K34_RS02250 (P1K34_02250)	vicK	430441..431793 (+)	1353	WP_111676637.1	cell wall metabolism sensor histidine kinase VicK	Regulator
P1K34_RS02255 (P1K34_02255)	vicX	431797..432606 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
P1K34_RS02260 (P1K34_02260)	rnc	433049..433741 (+)	693	WP_002990670.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51433.90 Da
• Isoelectric Point: 5.4026

>NTDB_id=800006 P1K34_RS02250 WP_111676637.1 430441..431793(+) (vicK) [Streptococcus pyogenes strain 1042]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTVTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=800006 P1K34_RS02250 WP_111676637.1 430441..431793(+) (vicK) [Streptococcus pyogenes strain 1042]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGACTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGTTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGTTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64