Detailed information NTG0798070

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: PY824_RS10230
• Genome accession: NZ_CP119172
• Coordinates: 1950441..1951172 (-)
• Length: 243 a.a.
• NCBI ID: WP_009855001.1
• Uniprot ID: A0A380K1N3
• Organism: Streptococcus macedonicus strain SGM CIP105683
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1945441..1956172

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PY824_RS10185 (PY824_10185)	-	1946687..1946944 (-)	258	WP_051673292.1	hypothetical protein	-
PY824_RS10190 (PY824_10190)	comD/comD3	1947077..1947391 (-)	315	WP_039671228.1	GHKL domain-containing protein	Regulator
PY824_RS10195 (PY824_10195)	-	1947523..1947693 (-)	171	WP_039671229.1	hypothetical protein	-
PY824_RS10200 (PY824_10200)	-	1947965..1948276 (-)	312	WP_039671231.1	bacteriocin immunity protein	-
PY824_RS10205 (PY824_10205)	-	1948288..1948437 (-)	150	WP_039671232.1	hypothetical protein	-
PY824_RS11680	-	1948447..1948644 (-)	198	WP_308292628.1	DUF3884 family protein	-
PY824_RS10215 (PY824_10215)	-	1948568..1948747 (-)	180	WP_223246323.1	hypothetical protein	-
PY824_RS10220 (PY824_10220)	-	1948967..1949104 (+)	138	WP_009854999.1	hypothetical protein	-
PY824_RS10225 (PY824_10225)	-	1949126..1950433 (-)	1308	WP_099412171.1	sensor histidine kinase	-
PY824_RS10230 (PY824_10230)	comE/comE1	1950441..1951172 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
PY824_RS10235 (PY824_10235)	-	1951189..1951473 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
PY824_RS10240 (PY824_10240)	-	1952353..1953522 (-)	1170	WP_039671238.1	MFS transporter	-
PY824_RS10245 (PY824_10245)	-	1953515..1954570 (-)	1056	WP_039671239.1	ThiF family adenylyltransferase	-
PY824_RS10250 (PY824_10250)	-	1954925..1956101 (+)	1177	Protein_1961	IS256-like element IS1191 family transposase	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28456.61 Da
• Isoelectric Point: 5.4335

>NTDB_id=798070 PY824_RS10230 WP_009855001.1 1950441..1951172(-) (comE/comE1) [Streptococcus macedonicus strain SGM CIP105683]
MLDIYVLEDNIIQQFRMEREIATIMAKNNWDYQRIEVFSSANEIIAKATEKGEHQIFFLDLEIRDDEKQGIDVAKAIREK
DATAIIVFVTTHSEFMLLTYQALVGAIDFIDKNLNDQAFSERIELCLKEAMKHQNDNFGENSFLFETPKARVRMPYSDIL
YFETSPAVHRVIMHTKNDRMEFYATIAEIAKSDKRLFKCHRSFIINVDNVVRFDKATRSVYFETGDTCLVSRDKIKPLLN
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=798070 PY824_RS10230 WP_009855001.1 1950441..1951172(-) (comE/comE1) [Streptococcus macedonicus strain SGM CIP105683]
ATGTTAGATATTTATGTACTAGAGGATAATATCATACAGCAATTTCGTATGGAACGCGAGATTGCGACCATTATGGCAAA
AAATAATTGGGACTATCAGAGAATAGAGGTGTTTAGTTCTGCAAATGAGATTATAGCTAAGGCAACTGAAAAAGGAGAGC
ATCAAATTTTCTTTCTTGATTTAGAAATCAGAGACGACGAAAAACAAGGAATTGATGTCGCTAAAGCTATTCGTGAAAAA
GATGCAACAGCTATCATTGTTTTTGTAACAACTCATTCAGAATTTATGCTGCTGACCTACCAAGCGTTAGTAGGGGCAAT
TGATTTTATTGATAAAAACCTAAATGACCAAGCATTTAGTGAACGCATAGAGTTGTGCCTAAAGGAAGCCATGAAACATC
AAAATGATAATTTCGGCGAAAACTCCTTTTTGTTTGAAACTCCTAAAGCACGTGTGCGCATGCCATATAGTGACATTCTC
TATTTTGAGACCTCTCCTGCTGTGCACCGCGTGATTATGCATACGAAAAATGACAGAATGGAATTTTATGCAACGATTGC
AGAGATTGCTAAATCAGACAAACGTCTTTTTAAGTGTCACCGTTCTTTTATCATTAATGTGGATAATGTGGTCAGATTTG
ATAAAGCGACACGAAGTGTTTATTTCGAAACTGGGGACACTTGCCTAGTTTCTAGAGATAAAATAAAACCTCTATTAAAT
GAGATGAGGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (11-123)

• LytTr DNA-binding domain (LytTR) (152-238)

3D structure

• AlphaFold DB: A0A380K1N3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	71.605	100	0.716
comE/blpR	Streptococcus mutans UA159	47.699	98.354	0.469
comE/comE2	Streptococcus equinus JB1	46.694	99.588	0.465