Detailed information NTG0797070

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: PYW31_RS04535
• Genome accession: NZ_CP118976
• Coordinates: 968680..969723 (+)
• Length: 347 a.a.
• NCBI ID: WP_046837882.1
• Uniprot ID: A0A1S2MGQ4
• Organism: Staphylococcus succinus strain DSM 14617
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 963680..974723

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PYW31_RS04510	-	964748..965467 (+)	720	WP_046837887.1	type 1 glutamine amidotransferase	-
PYW31_RS04515	-	965561..966547 (-)	987	WP_046837886.1	FUSC family protein	-
PYW31_RS04520	map	966722..967474 (+)	753	WP_046837885.1	type I methionyl aminopeptidase	-
PYW31_RS04525	-	967579..967965 (+)	387	WP_046837884.1	hypothetical protein	-
PYW31_RS04530	liaF	967982..968683 (+)	702	WP_046837883.1	cell wall-active antibiotics response protein LiaF	-
PYW31_RS04535	vraS	968680..969723 (+)	1044	WP_046837882.1	sensor histidine kinase	Regulator
PYW31_RS04540	vraR	969713..970342 (+)	630	WP_046837881.1	response regulator transcription factor	Regulator
PYW31_RS04545	-	970538..971683 (-)	1146	WP_046837880.1	YihY/virulence factor BrkB family protein	-
PYW31_RS04550	-	971899..972183 (-)	285	WP_046837879.1	hypothetical protein	-
PYW31_RS04555	-	972183..972653 (-)	471	WP_046837878.1	low molecular weight protein-tyrosine-phosphatase	-
PYW31_RS04560	-	972787..972993 (+)	207	WP_082104728.1	DUF1128 family protein	-
PYW31_RS04565	-	973009..974250 (+)	1242	WP_046837877.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40023.42 Da
• Isoelectric Point: 6.2448

>NTDB_id=797070 PYW31_RS04535 WP_046837882.1 968680..969723(+) (vraS) [Staphylococcus succinus strain DSM 14617]
MNHYLRAIGSMLILVYSTFFAIFFIDKVFVNIMYFQGMFYTQIFGIPVLLFLNLLVILLCIIVGSVLAYKINQQNHWLQE
QIERSIEGQTVGINDQNIELYNETIELYQTLVPLNQEVHKLRMKTQNLTNESYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESQLEAPLDQQIPVLEKMIQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVVDLQKKVPMKVVHDI
EEFKVPKGIEDHLFRITQEAISNTLRHSKGTKVTIELFNRTDYLLLRIQDNGKGFNVDEKAEQSYGLKNMRERALEIGAT
YHIVSLPDSGTRIEVKAPLNKEDSYAD

Nucleotide

• Length: 1044 bp

>NTDB_id=797070 PYW31_RS04535 WP_046837882.1 968680..969723(+) (vraS) [Staphylococcus succinus strain DSM 14617]
ATGAATCACTACTTAAGAGCAATAGGATCCATGTTAATTTTAGTCTATAGTACATTTTTCGCGATATTCTTTATTGATAA
AGTCTTTGTAAACATCATGTACTTTCAAGGTATGTTTTATACACAAATATTTGGAATACCAGTTTTACTATTTTTAAATT
TATTGGTTATATTGCTCTGTATTATAGTAGGATCAGTATTAGCTTATAAAATTAATCAACAGAACCATTGGTTACAAGAA
CAAATTGAACGTTCTATAGAAGGTCAAACTGTAGGGATTAATGATCAAAATATAGAGTTGTATAATGAAACGATAGAATT
ATATCAAACGCTTGTACCATTAAACCAAGAAGTGCACAAATTAAGAATGAAAACACAAAATTTGACGAATGAATCTTACA
ATATCAACGATGTAAAGGTTAAAAAGATTATAGAAGATGAACGACAAAGACTAGCACGTGAATTACACGATTCTGTAAGT
CAACAATTATTTGCTGCAAGTATGATGCTTTCTGCTATCAAAGAATCTCAATTAGAAGCACCTTTGGATCAACAAATCCC
AGTACTTGAAAAGATGATACAAGACTCTCAATTAGAGATGAGAGCACTATTATTACACTTAAGACCACTCGGCTTAAAAG
ATAAATCCTTAGGTGAAGGGATTAAAGATTTAGTTGTAGATTTACAGAAAAAGGTACCAATGAAAGTTGTCCATGATATC
GAAGAGTTTAAAGTACCAAAGGGTATTGAAGATCATTTGTTTAGAATTACACAAGAAGCAATTTCTAATACTTTGAGACA
TTCTAAGGGTACTAAGGTTACGATTGAATTGTTTAATAGAACAGATTATTTGCTATTGCGTATACAAGATAATGGTAAAG
GGTTTAATGTAGATGAAAAGGCTGAACAAAGTTATGGGTTGAAAAATATGAGAGAACGCGCATTGGAAATTGGCGCTACA
TATCATATTGTATCTTTACCAGACTCGGGAACAAGGATAGAAGTTAAGGCACCATTAAATAAGGAGGATTCATATGCCGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A1S2MGQ4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	88.184	100	0.882