NTDB

Overview

Name	mecA	Type	Regulator
Locus tag	RA106_RS00945	Genome accession	NZ_CP132900
Coordinates	164979..165728 (+)	Length	249 a.a.
NCBI ID	WP_011680667.1	Uniprot ID	Q03MN5
Organism	Streptococcus thermophilus strain CICC 20372
Function	degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 159979..170728

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RA106_RS00915 (RA106_00920)	-	160555..160725 (+)	171	WP_011680664.1	hypothetical protein	-
RA106_RS00920 (RA106_00925)	-	160812..160919 (+)	108	WP_011226802.1	LPXTG cell wall anchor domain-containing protein	-
RA106_RS00925 (RA106_00930)	-	161006..161746 (-)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
RA106_RS00930 (RA106_00935)	-	161746..163296 (-)	1551	WP_011680665.1	ABC transporter substrate-binding protein/permease	-
RA106_RS00935 (RA106_00940)	-	163499..164353 (+)	855	WP_011680666.1	undecaprenyl-diphosphate phosphatase	-
RA106_RS00940 (RA106_00945)	-	164405..164713 (-)	309	WP_306496352.1	DUF3021 family protein	-
RA106_RS00945 (RA106_00950)	mecA	164979..165728 (+)	750	WP_011680667.1	adaptor protein MecA	Regulator
RA106_RS00950 (RA106_00955)	-	165732..166889 (+)	1158	WP_002947632.1	glycosyltransferase family 4 protein	-
RA106_RS00955 (RA106_00960)	sufC	167049..167819 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
RA106_RS00960 (RA106_00965)	sufD	167856..169118 (+)	1263	WP_011680669.1	Fe-S cluster assembly protein SufD	-
RA106_RS00965 (RA106_00970)	-	169172..170404 (+)	1233	WP_011680670.1	cysteine desulfurase	-

Sequence

Protein

Download Length: 249 a.a. Molecular weight: 29174.68 Da Isoelectric Point: 4.0481

                                >NTDB_id=797032 RA106_RS00945 WP_011680667.1 164979..165728(+) (mecA) [Streptococcus thermophilus strain CICC 20372]

MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL

KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF

SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL

PVLQATKWS

Nucleotide

Download Length: 750 bp

                                >NTDB_id=797032 RA106_RS00945 WP_011680667.1 164979..165728(+) (mecA) [Streptococcus thermophilus strain CICC 20372]

ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT

GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT

TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT

AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT

TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG

ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC

TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG

TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC

TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA

CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q03MN5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
mecA	Streptococcus thermophilus LMD-9	100	100	1
mecA	Streptococcus thermophilus LMG 18311	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.787	97.992	0.566
mecA	Streptococcus pneumoniae Rx1	46.586	100	0.466
mecA	Streptococcus pneumoniae D39	46.586	100	0.466
mecA	Streptococcus pneumoniae R6	46.586	100	0.466
mecA	Streptococcus pneumoniae TIGR4	46.586	100	0.466

Detailed information NTG0797032