Detailed information
Bioinformatically predicted
Overview
| Name | vraR | Type | Regulator |
| Locus tag | PYH57_RS10365 | Genome accession | NZ_CP118810 |
| Coordinates | 2060756..2061385 (-) | Length | 209 a.a. |
| NCBI ID | WP_000153530.1 | Uniprot ID | D9IFM7 |
| Organism | Staphylococcus aureus strain 7062 | ||
| Function | repress expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2053678..2088378 | 2060756..2061385 | within | 0 |
Gene organization within MGE regions
Location: 2053678..2088378
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PYH57_RS10325 (PYH57_10315) | - | 2053678..2054724 (+) | 1047 | WP_353295320.1 | tyrosine-type recombinase/integrase | - |
| PYH57_RS10330 (PYH57_10320) | yfkAB | 2054769..2055914 (+) | 1146 | WP_353458956.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| PYH57_RS10335 (PYH57_10325) | - | 2056174..2056704 (-) | 531 | WP_000184381.1 | acyl-CoA thioesterase | - |
| PYH57_RS10340 (PYH57_10330) | - | 2056794..2058050 (-) | 1257 | WP_250425878.1 | aminopeptidase | - |
| PYH57_RS10345 (PYH57_10335) | - | 2058053..2058253 (-) | 201 | WP_000180460.1 | DUF1128 family protein | - |
| PYH57_RS10350 (PYH57_10340) | - | 2058400..2058864 (+) | 465 | WP_000228666.1 | low molecular weight protein-tyrosine-phosphatase | - |
| PYH57_RS10355 (PYH57_10345) | - | 2058871..2059146 (+) | 276 | WP_000428172.1 | YtxH domain-containing protein | - |
| PYH57_RS10360 (PYH57_10350) | - | 2059426..2060643 (+) | 1218 | WP_000037081.1 | YihY/virulence factor BrkB family protein | - |
| PYH57_RS10365 (PYH57_10355) | vraR | 2060756..2061385 (-) | 630 | WP_000153530.1 | two-component system response regulator VraR | Regulator |
| PYH57_RS10370 (PYH57_10360) | vraS | 2061375..2062418 (-) | 1044 | WP_001017131.1 | sensor histidine kinase | Regulator |
| PYH57_RS10375 (PYH57_10365) | liaF | 2062415..2063116 (-) | 702 | WP_000149070.1 | cell wall-active antibiotics response protein LiaF | - |
| PYH57_RS10380 (PYH57_10370) | - | 2063131..2063517 (-) | 387 | WP_001110179.1 | hypothetical protein | - |
| PYH57_RS10385 (PYH57_10375) | map | 2063734..2064492 (-) | 759 | WP_111014375.1 | type I methionyl aminopeptidase | - |
| PYH57_RS10390 (PYH57_10380) | - | 2065078..2066064 (+) | 987 | WP_000999713.1 | aromatic acid exporter family protein | - |
| PYH57_RS10395 (PYH57_10385) | - | 2066253..2066666 (-) | 414 | WP_025174666.1 | hypothetical protein | - |
| PYH57_RS10400 (PYH57_10390) | - | 2066695..2066805 (-) | 111 | WP_001790257.1 | hypothetical protein | - |
| PYH57_RS10405 (PYH57_10395) | - | 2066891..2067622 (-) | 732 | WP_000544977.1 | type 1 glutamine amidotransferase | - |
| PYH57_RS10410 (PYH57_10400) | murT | 2067624..2068937 (-) | 1314 | WP_001250333.1 | lipid II isoglutaminyl synthase subunit MurT | - |
| PYH57_RS10415 (PYH57_10405) | ftnA | 2069229..2069729 (+) | 501 | WP_000949467.1 | H-type ferritin FtnA | - |
| PYH57_RS10420 (PYH57_10410) | - | 2069811..2069903 (-) | 93 | WP_001790679.1 | hypothetical protein | - |
| PYH57_RS10425 (PYH57_10415) | - | 2070120..2070674 (+) | 555 | WP_000613738.1 | 3'-5' exonuclease | - |
| PYH57_RS10430 (PYH57_10420) | dinB | 2070741..2071811 (-) | 1071 | WP_000140176.1 | DNA polymerase IV | - |
| PYH57_RS10435 (PYH57_10425) | - | 2072057..2072587 (-) | 531 | WP_000548781.1 | DUF3267 domain-containing protein | - |
| PYH57_RS10440 (PYH57_10430) | rlmD | 2072757..2074118 (-) | 1362 | WP_001147861.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| PYH57_RS10445 (PYH57_10435) | - | 2074199..2075146 (-) | 948 | WP_001231462.1 | diacylglycerol kinase | - |
| PYH57_RS10450 (PYH57_10440) | - | 2075839..2075985 (-) | 147 | WP_000225074.1 | hypothetical protein | - |
| PYH57_RS10455 (PYH57_10445) | gatB | 2076024..2077451 (-) | 1428 | WP_000545370.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB | - |
| PYH57_RS10460 (PYH57_10450) | gatA | 2077464..2078921 (-) | 1458 | WP_000027928.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| PYH57_RS10465 (PYH57_10455) | gatC | 2078923..2079225 (-) | 303 | WP_000170162.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| PYH57_RS10470 (PYH57_10460) | putP | 2079591..2081129 (+) | 1539 | WP_000957020.1 | sodium/proline symporter PutP | - |
| PYH57_RS10475 (PYH57_10465) | - | 2081288..2081641 (-) | 354 | WP_000238681.1 | winged helix-turn-helix transcriptional regulator | - |
| PYH57_RS10480 (PYH57_10470) | - | 2081766..2082725 (+) | 960 | WP_000431628.1 | nitronate monooxygenase | - |
| PYH57_RS10485 (PYH57_10475) | - | 2082967..2084166 (-) | 1200 | WP_250425880.1 | CamS family sex pheromone protein | - |
| PYH57_RS10490 (PYH57_10480) | ligA | 2084179..2086182 (-) | 2004 | WP_000774565.1 | NAD-dependent DNA ligase LigA | - |
| PYH57_RS10495 (PYH57_10485) | pcrA | 2086186..2088378 (-) | 2193 | WP_262633472.1 | DNA helicase PcrA | - |
Sequence
Protein
Download Length: 209 a.a. Molecular weight: 23545.29 Da Isoelectric Point: 5.3889
>NTDB_id=795475 PYH57_RS10365 WP_000153530.1 2060756..2061385(-) (vraR) [Staphylococcus aureus strain 7062]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
Nucleotide
Download Length: 630 bp
>NTDB_id=795475 PYH57_RS10365 WP_000153530.1 2060756..2061385(-) (vraR) [Staphylococcus aureus strain 7062]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTAATCTATGCATTCCAACATAATTTAATTCAATAG
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTAATCTATGCATTCCAACATAATTTAATTCAATAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| vraR | Staphylococcus aureus N315 |
99.522 |
100 |
0.995 |
| degU | Bacillus subtilis subsp. subtilis str. 168 |
34.821 |
100 |
0.373 |