Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   PWK65_RS03505 Genome accession   NZ_CP118481
Coordinates   690728..691957 (+) Length   409 a.a.
NCBI ID   WP_002990162.1    Uniprot ID   Q1JM77
Organism   Streptococcus pyogenes strain 20185322     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 685728..696957
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PWK65_RS03480 (PWK65_03435) - 686344..687621 (-) 1278 WP_002990172.1 hydroxymethylglutaryl-CoA reductase, degradative -
  PWK65_RS03485 (PWK65_03440) - 687608..688783 (-) 1176 WP_002990170.1 hydroxymethylglutaryl-CoA synthase -
  PWK65_RS03490 (PWK65_03445) - 688992..689831 (+) 840 WP_002990167.1 thymidylate synthase -
  PWK65_RS03495 (PWK65_03450) - 689911..690408 (+) 498 WP_002984955.1 dihydrofolate reductase -
  PWK65_RS03500 (PWK65_03455) - 690428..690598 (+) 171 WP_002990165.1 hypothetical protein -
  PWK65_RS03505 (PWK65_03460) clpX 690728..691957 (+) 1230 WP_002990162.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  PWK65_RS03510 (PWK65_03465) yihA 691967..692566 (+) 600 WP_002990160.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  PWK65_RS03515 (PWK65_03470) - 692714..693457 (+) 744 WP_002984942.1 hypothetical protein -
  PWK65_RS03520 (PWK65_03475) - 693515..695614 (-) 2100 WP_002990158.1 AAA family ATPase -
  PWK65_RS03525 (PWK65_03480) rpiA 695992..696675 (+) 684 WP_002990155.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 45036.57 Da        Isoelectric Point: 4.6616

>NTDB_id=792668 PWK65_RS03505 WP_002990162.1 690728..691957(+) (clpX) [Streptococcus pyogenes strain 20185322]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELSEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLKTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=792668 PWK65_RS03505 WP_002990162.1 690728..691957(+) (clpX) [Streptococcus pyogenes strain 20185322]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGTCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTTAAAACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCGATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATTGAAGAAA
CAATGCTTGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q1JM77

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

88.753

100

0.888
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.603

98.044

0.575