NTDB

Overview

Name	braR	Type	Regulator
Locus tag	Q7622_RS04815	Genome accession	NZ_CP131711
Coordinates	946011..946688 (+)	Length	225 a.a.
NCBI ID	WP_000548959.1	Uniprot ID	Q9S1K2
Organism	Streptococcus pneumoniae strain 2014C08-275
Function	promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 941011..951688

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7622_RS04775 (Q7622_04775)	-	941116..941229 (-)	114	Protein_945	glutamine ABC transporter permease	-
Q7622_RS04780 (Q7622_04785)	-	941360..942006 (-)	647	Protein_946	nicotinamide mononucleotide transporter	-
Q7622_RS04785	-	942032..942223 (-)	192	WP_001816503.1	hypothetical protein	-
Q7622_RS04790 (Q7622_04790)	-	942204..942854 (-)	651	WP_000188505.1	metal-dependent transcriptional regulator	-
Q7622_RS04795 (Q7622_04795)	-	942966..943808 (+)	843	WP_000160938.1	metallophosphoesterase family protein	-
Q7622_RS04800 (Q7622_04800)	-	943884..944321 (+)	438	WP_001166785.1	Rrf2 family transcriptional regulator	-
Q7622_RS04805 (Q7622_04805)	-	944389..944691 (+)	303	WP_000281609.1	hypothetical protein	-
Q7622_RS04810 (Q7622_04810)	-	944782..945855 (-)	1074	WP_001273823.1	DUF2974 domain-containing protein	-
Q7622_RS04815 (Q7622_04815)	braR	946011..946688 (+)	678	WP_000548959.1	response regulator transcription factor	Regulator
Q7622_RS04820 (Q7622_04820)	-	946681..947655 (+)	975	WP_000887953.1	HAMP domain-containing histidine kinase	-
Q7622_RS04825 (Q7622_04825)	thrS	947704..949647 (-)	1944	WP_000608349.1	threonine--tRNA ligase	-
Q7622_RS04830 (Q7622_04830)	-	949705..949881 (-)	177	WP_000166031.1	MazG-like protein	-
Q7622_RS04835 (Q7622_04835)	-	949888..950028 (-)	141	WP_000422775.1	MazG-like protein	-
Q7622_RS04840 (Q7622_04840)	-	950458..950658 (-)	201	WP_001814296.1	hypothetical protein	-
Q7622_RS04845 (Q7622_04845)	-	950896..951525 (+)	630	WP_000762091.1	NAD(P)-dependent oxidoreductase	-

Sequence

Protein

Download Length: 225 a.a. Molecular weight: 25964.16 Da Isoelectric Point: 5.1362

                                >NTDB_id=791518 Q7622_RS04815 WP_000548959.1 946011..946688(+) (braR) [Streptococcus pneumoniae strain 2014C08-275]

MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS

RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL

RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Nucleotide

Download Length: 678 bp

                                >NTDB_id=791518 Q7622_RS04815 WP_000548959.1 946011..946688(+) (braR) [Streptococcus pneumoniae strain 2014C08-275]

ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA

AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG

GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG

AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT

TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG

TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA

CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT

TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA

CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-221)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q9S1K2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
braR	Staphylococcus aureus N315	48.624	96.889	0.471
vicR	Streptococcus mutans UA159	35.319	100	0.369

Detailed information NTG0791518