Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   Q7623_RS06145 Genome accession   NZ_CP131710
Coordinates   1202641..1203990 (-) Length   449 a.a.
NCBI ID   WP_061823223.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 2014S11-203     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1197641..1208990
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7623_RS06115 (Q7623_06095) - 1197704..1198690 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  Q7623_RS06120 (Q7623_06100) - 1198979..1199722 (-) 744 Protein_1210 ion channel -
  Q7623_RS06125 (Q7623_06105) - 1199769..1200023 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  Q7623_RS06130 (Q7623_06110) - 1200025..1200267 (-) 243 WP_000208080.1 DUF6290 family protein -
  Q7623_RS06135 (Q7623_06115) - 1200461..1201767 (+) 1307 Protein_1213 transposase -
  Q7623_RS06140 (Q7623_06120) vicX 1201830..1202639 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  Q7623_RS06145 (Q7623_06125) micB 1202641..1203990 (-) 1350 WP_061823223.1 cell wall metabolism sensor histidine kinase VicK Regulator
  Q7623_RS06150 (Q7623_06130) yycF 1203983..1204687 (-) 705 WP_000722076.1 response regulator YycF -
  Q7623_RS06155 (Q7623_06135) mutY 1204743..1205918 (-) 1176 WP_000886152.1 A/G-specific adenine glycosylase -
  Q7623_RS06160 (Q7623_06140) - 1206015..1206140 (+) 126 WP_001818232.1 hypothetical protein -
  Q7623_RS06165 (Q7623_06145) - 1206246..1207916 (-) 1671 WP_000845285.1 formate--tetrahydrofolate ligase -
  Q7623_RS06170 (Q7623_06150) coaB 1208146..1208835 (+) 690 WP_000699494.1 phosphopantothenate--cysteine ligase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51760.50 Da        Isoelectric Point: 4.8612

>NTDB_id=791413 Q7623_RS06145 WP_061823223.1 1202641..1203990(-) (micB) [Streptococcus pneumoniae strain 2014S11-203]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGESEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSLLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=791413 Q7623_RS06145 WP_061823223.1 1202641..1203990(-) (micB) [Streptococcus pneumoniae strain 2014S11-203]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGAGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAATGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGAGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCTCCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterProScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.332

100

0.993
  vicK Streptococcus mutans UA159

69.652

89.532

0.624