Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   Q7624_RS02075 Genome accession   NZ_CP131709
Coordinates   379821..380453 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain 2016S11-245     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 374821..385453
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7624_RS02050 (Q7624_02045) mvaD 375099..376052 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  Q7624_RS02055 (Q7624_02050) - 376039..377046 (+) 1008 WP_000562413.1 phosphomevalonate kinase -
  Q7624_RS02060 (Q7624_02055) fni 377030..378040 (+) 1011 WP_000210618.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  Q7624_RS02065 (Q7624_02060) liaF 378117..378815 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  Q7624_RS02070 (Q7624_02065) - 378812..379807 (+) 996 WP_000743674.1 sensor histidine kinase -
  Q7624_RS02075 (Q7624_02070) vraR 379821..380453 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  Q7624_RS02080 (Q7624_02075) - 380529..381223 (+) 695 Protein_407 DNA alkylation repair protein -
  Q7624_RS02085 (Q7624_02080) - 381373..381612 (+) 240 WP_000754501.1 hypothetical protein -
  Q7624_RS02090 (Q7624_02085) cbpG 381693..382283 (+) 591 Protein_409 choline-binding protein CbpG -
  Q7624_RS02095 (Q7624_02090) - 382585..382944 (+) 360 WP_000378123.1 tyrosine-type recombinase/integrase -
  Q7624_RS02100 (Q7624_02095) tig 383138..384421 (+) 1284 WP_000116462.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=791260 Q7624_RS02075 WP_000698434.1 379821..380453(+) (vraR) [Streptococcus pneumoniae strain 2016S11-245]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=791260 Q7624_RS02075 WP_000698434.1 379821..380453(+) (vraR) [Streptococcus pneumoniae strain 2016S11-245]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGTTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGAATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41