Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   Q7627_RS01985 Genome accession   NZ_CP131706
Coordinates   375452..376084 (+) Length   210 a.a.
NCBI ID   WP_000698433.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 2018N21-288     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 370452..381084
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7627_RS01960 (Q7627_01955) mvaD 370730..371683 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  Q7627_RS01965 (Q7627_01960) - 371670..372677 (+) 1008 WP_000562430.1 phosphomevalonate kinase -
  Q7627_RS01970 (Q7627_01965) fni 372661..373671 (+) 1011 WP_000210617.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  Q7627_RS01975 (Q7627_01970) liaF 373748..374446 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  Q7627_RS01980 (Q7627_01975) - 374443..375438 (+) 996 WP_000743657.1 sensor histidine kinase -
  Q7627_RS01985 (Q7627_01980) vraR 375452..376084 (+) 633 WP_000698433.1 response regulator transcription factor Regulator
  Q7627_RS01990 (Q7627_01985) - 376085..376327 (+) 243 Protein_389 DNA alkylation repair protein -
  Q7627_RS01995 (Q7627_01990) - 376252..376854 (+) 603 Protein_390 DNA alkylation repair protein -
  Q7627_RS02000 (Q7627_01995) - 377004..377243 (+) 240 WP_000754501.1 hypothetical protein -
  Q7627_RS02005 (Q7627_02000) cbpG 377324..377914 (+) 591 Protein_392 choline-binding protein CbpG -
  Q7627_RS02010 (Q7627_02005) - 378216..378608 (+) 393 WP_000378125.1 tyrosine-type recombinase/integrase -
  Q7627_RS02015 (Q7627_02010) tig 378769..380052 (+) 1284 WP_000116465.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23539.00 Da        Isoelectric Point: 4.5739

>NTDB_id=790909 Q7627_RS01985 WP_000698433.1 375452..376084(+) (vraR) [Streptococcus pneumoniae strain 2018N21-288]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQDEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=790909 Q7627_RS01985 WP_000698433.1 375452..376084(+) (vraR) [Streptococcus pneumoniae strain 2018N21-288]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGAATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAACATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGATGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41