Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   PUW62_RS04675 Genome accession   NZ_CP118046
Coordinates   948801..949475 (+) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus strain VSI52     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 943801..954475
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PUW62_RS04650 (PUW62_04650) - 945278..946237 (+) 960 WP_024052255.1 ROK family glucokinase -
  PUW62_RS04655 (PUW62_04655) rplS 946389..946736 (+) 348 WP_003024326.1 50S ribosomal protein L19 -
  PUW62_RS04665 (PUW62_04665) - 946977..947720 (+) 744 WP_070241645.1 alpha/beta hydrolase -
  PUW62_RS04670 (PUW62_04670) - 948068..948526 (+) 459 WP_024052212.1 hypothetical protein -
  PUW62_RS04675 (PUW62_04675) ciaR 948801..949475 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  PUW62_RS04680 (PUW62_04680) ciaH 949465..950811 (+) 1347 WP_024052211.1 HAMP domain-containing sensor histidine kinase Regulator
  PUW62_RS04685 (PUW62_04685) - 951286..952734 (-) 1449 WP_070241644.1 alpha-amylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=789477 PUW62_RS04675 WP_003024352.1 948801..949475(+) (ciaR) [Streptococcus anginosus strain VSI52]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=789477 PUW62_RS04675 WP_003024352.1 948801..949475(+) (ciaR) [Streptococcus anginosus strain VSI52]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCGGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATTTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTCTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGATTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTCGTAGAAGTCTATGTTTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362