Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   PUW62_RS04515 Genome accession   NZ_CP118046
Coordinates   912432..913664 (+) Length   410 a.a.
NCBI ID   WP_024052280.1    Uniprot ID   A0A412PMJ3
Organism   Streptococcus anginosus strain VSI52     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 910684..931980 912432..913664 within 0


Gene organization within MGE regions


Location: 910684..931980
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PUW62_RS04500 (PUW62_04500) - 910684..911523 (+) 840 WP_024052282.1 thymidylate synthase -
  PUW62_RS04505 (PUW62_04505) - 911708..912220 (+) 513 WP_274997409.1 dihydrofolate reductase -
  PUW62_RS04510 (PUW62_04510) - 912220..912393 (+) 174 WP_003024903.1 hypothetical protein -
  PUW62_RS04515 (PUW62_04515) clpX 912432..913664 (+) 1233 WP_024052280.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  PUW62_RS04520 (PUW62_04520) yihA 913676..914263 (+) 588 WP_024052279.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  PUW62_RS04525 (PUW62_04525) - 914444..915151 (+) 708 WP_003024892.1 glucosaminidase domain-containing protein -
  PUW62_RS04530 (PUW62_04530) - 915334..917079 (+) 1746 WP_042754049.1 ABC transporter ATP-binding protein -
  PUW62_RS04535 (PUW62_04535) - 917060..918808 (+) 1749 WP_024052277.1 ABC transporter ATP-binding protein -
  PUW62_RS04540 (PUW62_04540) - 918829..920364 (-) 1536 WP_070241652.1 ABC-F family ATP-binding cassette domain-containing protein -
  PUW62_RS04545 (PUW62_04545) - 920786..921526 (-) 741 WP_070241651.1 amino acid ABC transporter ATP-binding protein -
  PUW62_RS04550 (PUW62_04550) - 921526..923709 (-) 2184 WP_070241650.1 ABC transporter substrate-binding protein/permease -
  PUW62_RS04555 (PUW62_04555) - 923872..924831 (+) 960 WP_070241649.1 CPBP family intramembrane glutamic endopeptidase -
  PUW62_RS04560 (PUW62_04560) uvrB 924922..926910 (+) 1989 WP_024052272.1 excinuclease ABC subunit UvrB -
  PUW62_RS04565 (PUW62_04565) - 926941..927486 (+) 546 WP_070241648.1 DUF1697 domain-containing protein -
  PUW62_RS04570 (PUW62_04570) - 927616..928359 (+) 744 WP_070241647.1 ABC transporter ATP-binding protein -
  PUW62_RS04575 (PUW62_04575) - 928349..929989 (+) 1641 WP_070241646.1 hypothetical protein -
  PUW62_RS04580 (PUW62_04580) hemW 930115..931245 (+) 1131 WP_024052268.1 radical SAM family heme chaperone HemW -
  PUW62_RS04585 (PUW62_04585) - 931249..931980 (+) 732 WP_024052267.1 acyl-[acyl-carrier-protein] thioesterase -

Sequence

Protein


Download         Length: 410 a.a.        Molecular weight: 45718.24 Da        Isoelectric Point: 4.4242

>NTDB_id=789476 PUW62_RS04515 WP_024052280.1 912432..913664(+) (clpX) [Streptococcus anginosus strain VSI52]
MPTNRTNEMMVYCSFCGKSQEEVQKIIAGNNAFICNECVELAQEIIREELAEEVLADLSEVPKPQELLNILNHYVIGQDR
AKRALAVAVYNHYKRINFHDNREEEDDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQAADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDSIEEIVKQRLGEKIIGFGQNNKAIDETGSYMQEIISEDIQKFGLIPELIGRLPVFAALEPLTVDDLVR
ILREPKNALVKQYQTLLSYDDVKLEFDDDALQEIANKAIERKTGARGLRSIIEETMMDVMFEVPSQENVKLVRITKEAVD
GTDKPILETA

Nucleotide


Download         Length: 1233 bp        

>NTDB_id=789476 PUW62_RS04515 WP_024052280.1 912432..913664(+) (clpX) [Streptococcus anginosus strain VSI52]
ATGCCTACAAATCGTACGAATGAAATGATGGTTTATTGCTCTTTTTGTGGTAAAAGCCAAGAAGAAGTCCAAAAAATTAT
CGCAGGAAATAATGCCTTTATTTGTAATGAATGCGTGGAATTAGCGCAAGAAATCATCAGAGAGGAACTAGCAGAAGAAG
TACTAGCGGACTTGTCAGAAGTGCCAAAACCGCAAGAACTACTCAATATTTTGAATCATTATGTGATTGGGCAAGATCGT
GCTAAGCGAGCATTGGCTGTTGCTGTATACAATCACTATAAACGTATCAATTTTCACGATAATCGTGAAGAAGAGGATGA
TGTCGAATTACAAAAATCCAATATTCTTATGATTGGGCCAACTGGTTCTGGTAAGACTTTTCTTGCTCAAACCTTGGCGA
AAAGTCTGAATGTTCCTTTTGCGATTGCAGATGCGACAGCTTTGACAGAAGCTGGGTATGTCGGAGAAGATGTTGAAAAT
ATTCTCTTGAAACTCTTGCAAGCAGCAGATTTCAATATTGAGCGTGCAGAACGTGGTATCATCTATGTAGATGAGATTGA
CAAAATTGCGAAGAAAAGCGAAAACGTGTCTATTACTCGCGATGTGTCTGGTGAAGGCGTTCAGCAAGCGCTCCTCAAGA
TTATTGAAGGAACTGTAGCCAGCGTACCTCCGCAAGGCGGTCGCAAGCACCCTCAACAAGAAATGATTCAAGTAGATACC
AAGAATATTCTCTTTATCGTTGGTGGTGCATTTGACAGTATTGAAGAAATTGTCAAACAACGTCTAGGCGAAAAAATTAT
CGGTTTTGGTCAAAATAATAAAGCCATTGATGAAACTGGTTCTTATATGCAAGAAATCATCTCTGAAGATATTCAAAAAT
TTGGTTTGATTCCGGAATTGATTGGTCGTTTGCCTGTGTTTGCAGCGCTTGAGCCTTTGACAGTTGATGATTTGGTGCGA
ATCCTGCGCGAACCAAAGAATGCTTTAGTGAAGCAATATCAGACTCTCCTTTCTTATGACGATGTTAAACTAGAGTTTGA
TGATGATGCTCTTCAGGAAATTGCTAACAAGGCCATTGAACGCAAGACAGGTGCGCGTGGATTACGTTCAATCATTGAGG
AAACTATGATGGATGTTATGTTTGAAGTTCCAAGTCAAGAAAATGTGAAGCTGGTACGGATTACCAAGGAAGCAGTTGAT
GGAACGGATAAGCCGATTTTAGAAACAGCATAA

Domains

Predicted by InterproScan.

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(313-390)

AAA domain (Cdc48 subfamily) (AAA_2)

(111-306)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A412PMJ3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

86.341

100

0.863
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

57.96

98.049

0.568