Detailed information
Bioinformatically predicted
Overview
| Name | clpX | Type | Regulator |
| Locus tag | OTU45_RS08465 | Genome accession | NZ_CP113114 |
| Coordinates | 1665563..1666795 (-) | Length | 410 a.a. |
| NCBI ID | WP_000106346.1 | Uniprot ID | A0A064C077 |
| Organism | Streptococcus pneumoniae strain NP1 | ||
| Function | require for competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1620026..1676830 | 1665563..1666795 | within | 0 |
Gene organization within MGE regions
Location: 1620026..1676830
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OTU45_RS08140 (OTU45_08140) | - | 1620026..1620982 (-) | 957 | WP_267740954.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| OTU45_RS08145 (OTU45_08145) | - | 1620986..1621318 (-) | 333 | WP_001186206.1 | phage holin | - |
| OTU45_RS08150 (OTU45_08150) | - | 1621322..1621621 (-) | 300 | WP_001810279.1 | hypothetical protein | - |
| OTU45_RS08155 (OTU45_08155) | - | 1621631..1621981 (-) | 351 | WP_000852244.1 | hypothetical protein | - |
| OTU45_RS08160 (OTU45_08160) | - | 1621984..1622187 (-) | 204 | WP_001091123.1 | hypothetical protein | - |
| OTU45_RS12105 | - | 1622168..1622285 (-) | 118 | Protein_1621 | dihydrodipicolinate reductase | - |
| OTU45_RS08165 (OTU45_08165) | - | 1622282..1628638 (-) | 6357 | WP_267741165.1 | tail fiber domain-containing protein | - |
| OTU45_RS08170 (OTU45_08170) | - | 1628643..1628993 (-) | 351 | WP_000068023.1 | DUF6711 family protein | - |
| OTU45_RS08175 (OTU45_08175) | - | 1629002..1632595 (-) | 3594 | WP_267741197.1 | hypothetical protein | - |
| OTU45_RS08180 (OTU45_08180) | - | 1632582..1632932 (-) | 351 | WP_000478016.1 | hypothetical protein | - |
| OTU45_RS08185 (OTU45_08185) | - | 1632971..1633351 (-) | 381 | WP_001185639.1 | DUF6096 family protein | - |
| OTU45_RS08190 (OTU45_08190) | - | 1633356..1633769 (-) | 414 | WP_000880674.1 | phage tail tube protein | - |
| OTU45_RS08195 (OTU45_08195) | - | 1633772..1634140 (-) | 369 | WP_000608235.1 | hypothetical protein | - |
| OTU45_RS08200 (OTU45_08200) | - | 1634137..1634652 (-) | 516 | WP_000015941.1 | HK97-gp10 family putative phage morphogenesis protein | - |
| OTU45_RS08205 (OTU45_08205) | - | 1634627..1634965 (-) | 339 | WP_000478945.1 | hypothetical protein | - |
| OTU45_RS08210 (OTU45_08210) | - | 1634946..1635257 (-) | 312 | WP_000021220.1 | phage head-tail connector protein | - |
| OTU45_RS08215 (OTU45_08215) | - | 1635259..1635447 (-) | 189 | WP_000669352.1 | hypothetical protein | - |
| OTU45_RS08220 (OTU45_08220) | - | 1635437..1635619 (-) | 183 | WP_050111708.1 | Rho termination factor N-terminal domain-containing protein | - |
| OTU45_RS08225 (OTU45_08225) | - | 1635624..1636469 (-) | 846 | WP_000123893.1 | N4-gp56 family major capsid protein | - |
| OTU45_RS08230 (OTU45_08230) | - | 1636475..1637059 (-) | 585 | WP_001288026.1 | DUF4355 domain-containing protein | - |
| OTU45_RS08235 (OTU45_08235) | - | 1637286..1637537 (-) | 252 | WP_000890163.1 | DUF6275 family protein | - |
| OTU45_RS08240 (OTU45_08240) | - | 1637539..1637802 (-) | 264 | WP_000877355.1 | hypothetical protein | - |
| OTU45_RS08245 (OTU45_08245) | - | 1637845..1638258 (-) | 414 | WP_000565273.1 | HD domain-containing protein | - |
| OTU45_RS08250 (OTU45_08250) | - | 1638255..1638464 (-) | 210 | WP_000651746.1 | hypothetical protein | - |
| OTU45_RS08255 (OTU45_08255) | - | 1638466..1640103 (-) | 1638 | WP_164993540.1 | minor capsid protein | - |
| OTU45_RS08260 (OTU45_08260) | - | 1640012..1641481 (-) | 1470 | WP_000285392.1 | phage portal protein | - |
| OTU45_RS08265 (OTU45_08265) | - | 1641493..1642791 (-) | 1299 | WP_050111709.1 | PBSX family phage terminase large subunit | - |
| OTU45_RS08270 (OTU45_08270) | - | 1642769..1643209 (-) | 441 | WP_001859583.1 | terminase small subunit | - |
| OTU45_RS08280 (OTU45_08280) | - | 1643604..1644065 (-) | 462 | WP_001030245.1 | DUF1492 domain-containing protein | - |
| OTU45_RS08285 (OTU45_08285) | - | 1644140..1644454 (-) | 315 | WP_050111710.1 | hypothetical protein | - |
| OTU45_RS08290 (OTU45_08290) | - | 1644475..1644654 (-) | 180 | WP_001042650.1 | hypothetical protein | - |
| OTU45_RS08295 (OTU45_08295) | - | 1644647..1645042 (-) | 396 | WP_000612393.1 | YopX family protein | - |
| OTU45_RS08300 (OTU45_08300) | - | 1645186..1645308 (-) | 123 | WP_001859025.1 | hypothetical protein | - |
| OTU45_RS08305 (OTU45_08305) | - | 1645347..1645853 (-) | 507 | WP_001041162.1 | DUF1642 domain-containing protein | - |
| OTU45_RS08310 (OTU45_08310) | - | 1645855..1646167 (-) | 313 | Protein_1650 | hypothetical protein | - |
| OTU45_RS08315 (OTU45_08315) | - | 1646318..1646656 (-) | 339 | WP_000119453.1 | hypothetical protein | - |
| OTU45_RS08320 (OTU45_08320) | - | 1646656..1646808 (-) | 153 | WP_000122746.1 | hypothetical protein | - |
| OTU45_RS08325 (OTU45_08325) | - | 1647102..1648445 (-) | 1344 | WP_267741732.1 | virulence-associated E family protein | - |
| OTU45_RS08330 (OTU45_08330) | - | 1648448..1649269 (-) | 822 | WP_001838318.1 | bifunctional DNA primase/polymerase | - |
| OTU45_RS08335 (OTU45_08335) | - | 1649442..1649948 (-) | 507 | WP_000054340.1 | hypothetical protein | - |
| OTU45_RS08340 (OTU45_08340) | - | 1649968..1650795 (-) | 828 | WP_000885997.1 | AAA family ATPase | - |
| OTU45_RS08345 (OTU45_08345) | - | 1650795..1651112 (-) | 318 | WP_001044592.1 | hypothetical protein | - |
| OTU45_RS08350 (OTU45_08350) | - | 1651131..1652324 (-) | 1194 | WP_000028860.1 | DEAD/DEAH box helicase family protein | - |
| OTU45_RS08355 (OTU45_08355) | - | 1652287..1652772 (-) | 486 | WP_000696056.1 | hypothetical protein | - |
| OTU45_RS08360 (OTU45_08360) | - | 1652772..1653122 (-) | 351 | WP_224782710.1 | hypothetical protein | - |
| OTU45_RS08365 (OTU45_08365) | - | 1653131..1653613 (-) | 483 | WP_000157807.1 | siphovirus Gp157 family protein | - |
| OTU45_RS08370 (OTU45_08370) | - | 1653606..1654328 (-) | 723 | WP_000544344.1 | HNH endonuclease signature motif containing protein | - |
| OTU45_RS08375 (OTU45_08375) | - | 1654342..1654572 (-) | 231 | WP_000252080.1 | hypothetical protein | - |
| OTU45_RS08380 (OTU45_08380) | - | 1654573..1654914 (-) | 342 | WP_000189407.1 | hypothetical protein | - |
| OTU45_RS08385 (OTU45_08385) | - | 1654926..1655114 (-) | 189 | WP_267741839.1 | hypothetical protein | - |
| OTU45_RS08390 (OTU45_08390) | - | 1655114..1655308 (-) | 195 | WP_001050924.1 | hypothetical protein | - |
| OTU45_RS08395 (OTU45_08395) | - | 1655305..1655577 (-) | 273 | WP_000388508.1 | hypothetical protein | - |
| OTU45_RS08400 (OTU45_08400) | - | 1655820..1656356 (-) | 537 | WP_000446710.1 | hypothetical protein | - |
| OTU45_RS08405 (OTU45_08405) | - | 1656388..1656603 (-) | 216 | WP_001198772.1 | helix-turn-helix transcriptional regulator | - |
| OTU45_RS08410 (OTU45_08410) | - | 1656616..1656801 (-) | 186 | WP_023396929.1 | helix-turn-helix domain-containing protein | - |
| OTU45_RS08415 (OTU45_08415) | - | 1656949..1657140 (+) | 192 | WP_000834623.1 | hypothetical protein | - |
| OTU45_RS08420 (OTU45_08420) | - | 1657357..1658046 (+) | 690 | WP_000577241.1 | DUF4145 domain-containing protein | - |
| OTU45_RS08425 (OTU45_08425) | - | 1658290..1659075 (+) | 786 | WP_407082878.1 | helix-turn-helix domain-containing protein | - |
| OTU45_RS08430 (OTU45_08430) | - | 1659097..1660167 (+) | 1071 | WP_000420652.1 | hypothetical protein | - |
| OTU45_RS08435 (OTU45_08435) | - | 1660537..1661664 (+) | 1128 | WP_050111715.1 | tyrosine-type recombinase/integrase | - |
| OTU45_RS08440 (OTU45_08440) | whiA | 1661752..1662663 (-) | 912 | WP_000011306.1 | DNA-binding protein WhiA | - |
| OTU45_RS08445 (OTU45_08445) | - | 1662660..1663637 (-) | 978 | WP_001231086.1 | YvcK family protein | - |
| OTU45_RS08450 (OTU45_08450) | rapZ | 1663634..1664524 (-) | 891 | WP_000163035.1 | RNase adapter RapZ | - |
| OTU45_RS08455 (OTU45_08455) | - | 1664576..1664956 (-) | 381 | WP_001140412.1 | RidA family protein | - |
| OTU45_RS08460 (OTU45_08460) | yihA | 1664967..1665554 (-) | 588 | WP_000422597.1 | ribosome biogenesis GTP-binding protein YihA/YsxC | - |
| OTU45_RS08465 (OTU45_08465) | clpX | 1665563..1666795 (-) | 1233 | WP_000106346.1 | ATP-dependent Clp protease ATP-binding subunit ClpX | Regulator |
| OTU45_RS08470 (OTU45_08470) | - | 1666832..1667002 (-) | 171 | WP_000442258.1 | hypothetical protein | - |
| OTU45_RS08475 (OTU45_08475) | - | 1667002..1667508 (-) | 507 | WP_267742105.1 | dihydrofolate reductase | - |
| OTU45_RS08480 (OTU45_08480) | - | 1667638..1668156 (-) | 519 | WP_267742107.1 | Dps family protein | - |
| OTU45_RS08485 (OTU45_08485) | lytC | 1668620..1670110 (-) | 1491 | WP_267742109.1 | choline binding-anchored murein hydrolase LytC | - |
| OTU45_RS08490 (OTU45_08490) | tpiA | 1670148..1670906 (-) | 759 | WP_000087891.1 | triose-phosphate isomerase | - |
| OTU45_RS08495 (OTU45_08495) | - | 1671005..1671682 (-) | 678 | WP_267742120.1 | DnaD domain-containing protein | - |
| OTU45_RS08500 (OTU45_08500) | metA | 1671691..1672635 (-) | 945 | WP_001122714.1 | homoserine O-acetyltransferase MetA | - |
| OTU45_RS08505 (OTU45_08505) | - | 1672817..1673329 (-) | 513 | WP_001049323.1 | adenine phosphoribosyltransferase | - |
| OTU45_RS08510 (OTU45_08510) | - | 1673416..1674174 (-) | 759 | WP_001287230.1 | class I SAM-dependent methyltransferase | - |
| OTU45_RS08515 (OTU45_08515) | - | 1674382..1674552 (+) | 171 | WP_000403101.1 | hypothetical protein | - |
| OTU45_RS08520 (OTU45_08520) | - | 1674674..1675804 (-) | 1131 | WP_000229961.1 | ABC transporter ATP-binding protein | - |
| OTU45_RS08530 (OTU45_08530) | - | 1676255..1676830 (-) | 576 | WP_000158722.1 | cysteine hydrolase family protein | - |
Sequence
Protein
Download Length: 410 a.a. Molecular weight: 45798.35 Da Isoelectric Point: 4.4550
>NTDB_id=760345 OTU45_RS08465 WP_000106346.1 1665563..1666795(-) (clpX) [Streptococcus pneumoniae strain NP1]
MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQEIIREELVEEVLADLSEVPKPIELLHILNHYVIGQDR
AKRALAVAVYNHYKRINFHDTREESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAIDENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVR
ILKEPRNALVKQYQTLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLVRITKETVD
GTDKPILETA
MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQEIIREELVEEVLADLSEVPKPIELLHILNHYVIGQDR
AKRALAVAVYNHYKRINFHDTREESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAIDENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVR
ILKEPRNALVKQYQTLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLVRITKETVD
GTDKPILETA
Nucleotide
Download Length: 1233 bp
>NTDB_id=760345 OTU45_RS08465 WP_000106346.1 1665563..1666795(-) (clpX) [Streptococcus pneumoniae strain NP1]
ATGTCTACAAATAGAAAAAATGATATGATGGTTTATTGCTCATTTTGTGGCAAAAACCAAGAAGAAGTACAAAAAATAAT
TGCTGGCAACAATGCTTTTATTTGTAATGAATGCGTGGAGTTAGCTCAGGAAATCATTCGAGAAGAATTGGTTGAGGAAG
TCTTGGCAGACTTGTCTGAGGTGCCAAAACCAATTGAACTCCTCCATATCTTGAACCACTATGTAATTGGTCAAGATCGT
GCCAAGCGTGCCTTGGCAGTGGCGGTTTATAACCACTACAAACGCATCAATTTCCACGATACACGCGAAGAGTCAGAAGA
TGTGGATTTGCAGAAGTCAAACATTTTGATGATTGGCCCAACTGGTTCAGGGAAAACTTTCCTTGCCCAGACCTTGGCTA
AGAGCTTGAATGTACCTTTTGCTATTGCGGATGCGACAGCTCTGACGGAGGCTGGTTATGTGGGTGAGGATGTGGAAAAT
ATCCTCCTCAAACTCTTGCAGGTTGCTGACTTTAACATCGAACGTGCAGAGCGTGGCATTATCTATGTGGATGAAATTGA
CAAGATTGCCAAGAAGAGTGAGAATGTGTCTATCACACGTGATGTTTCTGGTGAAGGGGTGCAACAAGCCCTTCTCAAGA
TTATCGAGGGAACTGTTGCTAGCGTACCGCCTCAAGGTGGACGCAAACATCCACAACAAGAGATGATTCAAGTGGATACA
AAAAATATCCTCTTCATCGTGGGTGGTGCTTTTGATGGTATTGAAGAAATTGTCAAACAACGTCTGGGTGAAAAAGTCAT
CGGATTTGGTCAAAACAATAAGGCGATTGACGAAAACAGCTCATACATGCAAGAAATCATCGCTGAAGACATTCAAAAAT
TTGGTATTATCCCTGAGTTGATTGGACGCTTGCCTGTTTTTGCGGCTCTTGAGCAATTGACCGTTGATGACTTGGTTCGC
ATCTTGAAAGAGCCAAGAAATGCCTTGGTGAAACAATACCAAACCTTGCTTTCTTATGATGATGTTGAGTTGGAATTTGA
CGACGAAGCCCTTCAAGAGATTGCTAATAAAGCAATCGAACGGAAGACAGGGGCGCGTGGACTTCGCTCCATCATCGAAG
AAACCATGCTAGATGTTATGTTTGAGGTGCCGAGTCAGGAAAATGTGAAATTGGTTCGCATCACTAAAGAAACTGTCGAT
GGAACGGATAAACCGATCCTAGAAACAGCCTAG
ATGTCTACAAATAGAAAAAATGATATGATGGTTTATTGCTCATTTTGTGGCAAAAACCAAGAAGAAGTACAAAAAATAAT
TGCTGGCAACAATGCTTTTATTTGTAATGAATGCGTGGAGTTAGCTCAGGAAATCATTCGAGAAGAATTGGTTGAGGAAG
TCTTGGCAGACTTGTCTGAGGTGCCAAAACCAATTGAACTCCTCCATATCTTGAACCACTATGTAATTGGTCAAGATCGT
GCCAAGCGTGCCTTGGCAGTGGCGGTTTATAACCACTACAAACGCATCAATTTCCACGATACACGCGAAGAGTCAGAAGA
TGTGGATTTGCAGAAGTCAAACATTTTGATGATTGGCCCAACTGGTTCAGGGAAAACTTTCCTTGCCCAGACCTTGGCTA
AGAGCTTGAATGTACCTTTTGCTATTGCGGATGCGACAGCTCTGACGGAGGCTGGTTATGTGGGTGAGGATGTGGAAAAT
ATCCTCCTCAAACTCTTGCAGGTTGCTGACTTTAACATCGAACGTGCAGAGCGTGGCATTATCTATGTGGATGAAATTGA
CAAGATTGCCAAGAAGAGTGAGAATGTGTCTATCACACGTGATGTTTCTGGTGAAGGGGTGCAACAAGCCCTTCTCAAGA
TTATCGAGGGAACTGTTGCTAGCGTACCGCCTCAAGGTGGACGCAAACATCCACAACAAGAGATGATTCAAGTGGATACA
AAAAATATCCTCTTCATCGTGGGTGGTGCTTTTGATGGTATTGAAGAAATTGTCAAACAACGTCTGGGTGAAAAAGTCAT
CGGATTTGGTCAAAACAATAAGGCGATTGACGAAAACAGCTCATACATGCAAGAAATCATCGCTGAAGACATTCAAAAAT
TTGGTATTATCCCTGAGTTGATTGGACGCTTGCCTGTTTTTGCGGCTCTTGAGCAATTGACCGTTGATGACTTGGTTCGC
ATCTTGAAAGAGCCAAGAAATGCCTTGGTGAAACAATACCAAACCTTGCTTTCTTATGATGATGTTGAGTTGGAATTTGA
CGACGAAGCCCTTCAAGAGATTGCTAATAAAGCAATCGAACGGAAGACAGGGGCGCGTGGACTTCGCTCCATCATCGAAG
AAACCATGCTAGATGTTATGTTTGAGGTGCCGAGTCAGGAAAATGTGAAATTGGTTCGCATCACTAAAGAAACTGTCGAT
GGAACGGATAAACCGATCCTAGAAACAGCCTAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpX | Streptococcus mutans UA159 |
86.585 |
100 |
0.866 |
| clpX | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 |
57.214 |
98.049 |
0.561 |