Detailed information NTG0759233

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: OS075_RS07015
• Genome accession: NZ_CP113029
• Coordinates: 1363006..1364049 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Zoe
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1358006..1369049

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OS075_RS06985	-	1358376..1358486 (+)	111	WP_001790257.1	hypothetical protein	-
OS075_RS06990	-	1358515..1358928 (+)	414	WP_001549145.1	hypothetical protein	-
OS075_RS06995	-	1359418..1360404 (-)	987	WP_000999713.1	FUSC family protein	-
OS075_RS07000	map	1360932..1361690 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
OS075_RS07005	-	1361907..1362293 (+)	387	WP_001110179.1	hypothetical protein	-
OS075_RS07010	liaF	1362308..1363009 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
OS075_RS07015	vraS	1363006..1364049 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
OS075_RS07020	vraR	1364039..1364668 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
OS075_RS07025	-	1364784..1366001 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
OS075_RS07030	-	1366279..1366554 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
OS075_RS07035	-	1366561..1367025 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
OS075_RS07040	-	1367172..1367372 (+)	201	WP_000180461.1	DUF1128 family protein	-
OS075_RS07045	-	1367375..1368631 (+)	1257	WP_267836439.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=759233 OS075_RS07015 WP_001017131.1 1363006..1364049(+) (vraS) [Staphylococcus aureus strain Zoe]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=759233 OS075_RS07015 WP_001017131.1 1363006..1364049(+) (vraS) [Staphylococcus aureus strain Zoe]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1