Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   FPG46_RS00290 Genome accession   NZ_AP019751
Coordinates   60035..61384 (-) Length   449 a.a.
NCBI ID   WP_144078867.1    Uniprot ID   -
Organism   Staphylococcus aureus strain JRA307     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39295..74618 60035..61384 within 0


Gene organization within MGE regions


Location: 39295..74618
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FPG46_RS00175 (SAJRA307_00330) mecA 39295..41304 (-) 2010 WP_063852655.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  FPG46_RS00180 (SAJRA307_00340) mecR1 41401..43158 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  FPG46_RS00185 (SAJRA307_00350) mecI 43158..43529 (+) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  FPG46_RS00190 psm-mec 43614..43682 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  FPG46_RS00195 (SAJRA307_00360) - 44002..45150 (+) 1149 WP_000427807.1 ROK family transcriptional regulator -
  FPG46_RS00200 (SAJRA307_00380) cstB 45264..46598 (-) 1335 Protein_34 persulfide dioxygenase-sulfurtransferase CstB -
  FPG46_RS00205 (SAJRA307_00390) - 46631..47695 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  FPG46_RS00210 (SAJRA307_00400) cstR 47831..48091 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  FPG46_RS00215 (SAJRA307_00410) - 48091..48729 (+) 639 Protein_37 sulfite exporter TauE/SafE family protein -
  FPG46_RS00225 (SAJRA307_00420) - 49003..49620 (-) 618 WP_000562107.1 CadD family cadmium resistance transporter -
  FPG46_RS00230 (SAJRA307_00430) - 49701..52115 (-) 2415 WP_000378485.1 cadmium-translocating P-type ATPase CadA -
  FPG46_RS00235 (SAJRA307_00440) - 52108..52473 (-) 366 WP_000159127.1 ArsR/SmtB family transcription factor -
  FPG46_RS00240 (SAJRA307_00450) - 52711..53088 (-) 378 WP_001041908.1 DUF6262 family protein -
  FPG46_RS00245 (SAJRA307_00460) - 53095..54987 (-) 1893 WP_002485298.1 site-specific integrase -
  FPG46_RS00250 (SAJRA307_00470) - 55182..55505 (-) 324 WP_000088091.1 JAB domain-containing protein -
  FPG46_RS00255 (SAJRA307_00480) - 55498..55704 (-) 207 WP_001077283.1 hypothetical protein -
  FPG46_RS00260 (SAJRA307_00490) - 55706..56227 (-) 522 WP_144078863.1 DUF1643 domain-containing protein -
  FPG46_RS00265 (SAJRA307_00500) - 56246..56557 (-) 312 WP_069855724.1 DUF960 family protein -
  FPG46_RS00275 (SAJRA307_00520) - 56642..56992 (-) 351 WP_144078864.1 SAUGI family uracil-DNA glycosylase inhibitor -
  FPG46_RS00280 (SAJRA307_00530) - 57563..58297 (-) 735 WP_144078865.1 glucose 1-dehydrogenase -
  FPG46_RS00285 (SAJRA307_00540) ccrB 58385..60013 (-) 1629 WP_144078866.1 cassette chromosome recombinase CcrB Machinery gene
  FPG46_RS00290 (SAJRA307_00550) ccrA 60035..61384 (-) 1350 WP_144078867.1 cassette chromosome recombinase CcrA Machinery gene
  FPG46_RS00295 (SAJRA307_00560) cch1 61563..63308 (-) 1746 WP_232049855.1 cassette chromosome replicative helicase -
  FPG46_RS00300 (SAJRA307_00570) ssb 63356..63646 (-) 291 WP_144078869.1 cassette chromosome ssDNA-binding protein -
  FPG46_RS00305 (SAJRA307_00580) - 63805..65349 (-) 1545 WP_144078870.1 hypothetical protein -
  FPG46_RS00310 (SAJRA307_00590) - 65834..66883 (+) 1050 WP_144078871.1 ATP-binding protein -
  FPG46_RS00315 (SAJRA307_00600) - 66876..69089 (+) 2214 WP_144078872.1 S8 family peptidase -
  FPG46_RS00320 (SAJRA307_00610) blaZ 69461..70312 (-) 852 WP_144078873.1 mecC-type penicillin-hydrolyzing class A beta-lactamase BlaZ -
  FPG46_RS00325 (SAJRA307_00620) - 70407..72404 (-) 1998 WP_128268231.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecC2 -
  FPG46_RS00330 (SAJRA307_00630) - 72527..74260 (+) 1734 WP_172607350.1 BlaR1 family beta-lactam sensor/signal transducer -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52309.31 Da        Isoelectric Point: 9.9662

>NTDB_id=73796 FPG46_RS00290 WP_144078867.1 60035..61384(-) (ccrA) [Staphylococcus aureus strain JRA307]
MKQAIGYLRQSTTKQQSLGAQRQTIETLAKKYNIQHITFYSDKQSGRTDNRTGYQQVIKSIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKSFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQSKLITTHAPFGYDYR
NGTFIINNDEAPTVKAVFNYYLQGYGYKKIAQYLEDDNKFINRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATI
YEHAQAILNKKQLHCIPSENQLKQKIKCPCCGSTLTNMTIRKTNHSLRYYVCPKNMNASRFICDFKGINAENLEKQVLES
CQKFFRDQQLYSKIKHAIEKQLKKQRMHDTSNTLTHEKLIEKLAQGTIDVETFREQSQLINLQNKPIQATSDIRIKALLQ
KVIQKSFTLNMLYPYIDVIHITKNKELSGIYLKNEPINIVNQTIQSSTA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=73796 FPG46_RS00290 WP_144078867.1 60035..61384(-) (ccrA) [Staphylococcus aureus strain JRA307]
ATGAAACAAGCTATTGGTTATTTACGCCAAAGTACAACCAAGCAACAATCCCTAGGAGCACAGAGACAAACTATCGAAAC
GCTCGCTAAAAAATACAATATCCAACACATCACCTTTTATAGTGATAAGCAATCAGGCAGAACGGATAACCGAACAGGTT
ATCAACAAGTCATCAAAAGCATTCAACAAAGACAATGTGACGTATTATGTTGTTATCGATTAAATCGACTGCATCGTAAT
TTGAAAAATGCATTAAAACTTATGAAACTGTGTCAAAAGTATCATGTTCATATTCTAAGTGTACATGATGGTTATTTTGA
TATGGATAAATCTTTTGATCGTCTAAAACTCAATATTTTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAAGTAAACTCATAACGACTCATGCGCCATTCGGTTATGACTATCGA
AATGGTACTTTCATCATTAATAATGATGAAGCACCTACTGTCAAAGCTGTATTCAACTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAGTTTATTAACCGTAAGCCTTATCAAGTACGAAATATTATTATGA
ACCCTAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTTCCACCTATTGTTTCGGCAACGATA
TATGAACATGCTCAAGCAATCCTTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAAATAAA
ATGTCCTTGTTGTGGTTCAACCCTTACCAATATGACCATTAGAAAAACCAATCATTCATTACGTTATTATGTCTGTCCTA
AAAACATGAATGCATCACGTTTCATATGTGACTTTAAAGGCATAAACGCTGAAAACCTAGAAAAACAGGTCTTAGAATCT
TGCCAAAAATTCTTTCGAGACCAACAGCTCTATTCGAAAATCAAACATGCTATTGAGAAACAGCTCAAAAAACAAAGGAT
GCATGATACTAGTAACACATTAACTCATGAAAAGCTCATTGAAAAATTAGCTCAAGGAACAATTGATGTAGAAACATTCA
GAGAACAATCTCAATTAATAAATCTACAGAATAAGCCTATACAAGCAACAAGTGATATTCGGATAAAAGCATTGCTACAA
AAGGTTATACAGAAAAGTTTCACGTTAAACATGTTATATCCCTATATTGATGTCATTCATATTACTAAAAATAAAGAACT
AAGCGGAATCTATTTAAAAAATGAGCCAATAAACATCGTTAATCAAACGATACAATCATCAACTGCCTAA

Domains

Predicted by InterproScan.

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Recombinase (Recombinase)

(168-250)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

76.063

99.555

0.757
  ccrA Staphylococcus aureus N315

70.824

100

0.708

Multiple sequence alignment