Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   P8191_RS09875 Genome accession   NZ_CP121250
Coordinates   1931714..1932355 (+) Length   213 a.a.
NCBI ID   WP_010922536.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 1044     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1926714..1937355
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8191_RS09855 (P8191_09855) - 1927270..1928010 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  P8191_RS09860 (P8191_09860) pknB 1928007..1929905 (+) 1899 WP_010922538.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  P8191_RS09865 (P8191_09865) liaF 1930028..1930720 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  P8191_RS09870 (P8191_09870) - 1930717..1931721 (+) 1005 WP_002991890.1 sensor histidine kinase -
  P8191_RS09875 (P8191_09875) vraR 1931714..1932355 (+) 642 WP_010922536.1 response regulator transcription factor Regulator
  P8191_RS09880 (P8191_09880) - 1932392..1933792 (+) 1401 WP_011285657.1 Cof-type HAD-IIB family hydrolase -
  P8191_RS09885 (P8191_09885) - 1933792..1934169 (+) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  P8191_RS09890 (P8191_09890) cysK 1934187..1935128 (-) 942 WP_010922535.1 cysteine synthase A -
  P8191_RS09895 (P8191_09895) - 1935256..1935888 (-) 633 WP_029714065.1 YigZ family protein -
  P8191_RS09900 (P8191_09900) comFA/cflA 1935944..1937269 (+) 1326 WP_010922534.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23693.40 Da        Isoelectric Point: 5.3506

>NTDB_id=736656 P8191_RS09875 WP_010922536.1 1931714..1932355(+) (vraR) [Streptococcus pyogenes strain 1044]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVGDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=736656 P8191_RS09875 WP_010922536.1 1931714..1932355(+) (vraR) [Streptococcus pyogenes strain 1044]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGGTGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(148-202)

Response regulator receiver domain (Response_reg)

(6-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385