Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   P7249_RS10130 Genome accession   NZ_CP120944
Coordinates   2045499..2046155 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O157:H7 str. EDL933     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2040499..2051155
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P7249_RS10100 dcyD 2041378..2042364 (+) 987 WP_001128225.1 D-cysteine desulfhydrase -
  P7249_RS10105 tcyL 2042379..2043047 (+) 669 WP_001158226.1 cystine ABC transporter permease -
  P7249_RS10110 tcyN 2043044..2043796 (+) 753 WP_001273005.1 L-cystine ABC transporter ATP-binding protein TcyN -
  P7249_RS10115 sdiA 2044026..2044748 (+) 723 WP_001154288.1 transcriptional regulator SdiA -
  P7249_RS10120 yecF 2044816..2045040 (-) 225 WP_000106479.1 DUF2594 family protein YecF -
  P7249_RS10125 yecU 2045027..2045203 (-) 177 WP_001302050.1 protein YecU -
  P7249_RS27665 - 2045241..2045357 (-) 117 WP_001302039.1 hypothetical protein -
  P7249_RS10130 letA 2045499..2046155 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  P7249_RS10135 uvrC 2046152..2047984 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  P7249_RS10140 pgsA 2048041..2048589 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  P7249_RS10160 - 2049581..2049862 (+) 282 WP_001303543.1 hypothetical protein -
  P7249_RS10165 - 2049883..2050077 (+) 195 WP_115801851.1 hypothetical protein -
  P7249_RS10170 - 2050019..2051152 (+) 1134 WP_032161728.1 IS30-like element IS30 family transposase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=735360 P7249_RS10130 WP_000611328.1 2045499..2046155(+) (letA) [Escherichia coli O157:H7 str. EDL933]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=735360 P7249_RS10130 WP_000611328.1 2045499..2046155(+) (letA) [Escherichia coli O157:H7 str. EDL933]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTAAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCTGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CATTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACGAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482