Detailed information NTG0073305

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAP2_RS04775
• Genome accession: NZ_AP019698
• Coordinates: 1005603..1006646 (+)
• Length: 347 a.a.
• NCBI ID: WP_002509180.1
• Uniprot ID: A0A7V7SQH4
• Organism: Staphylococcus arlettae strain P2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1000603..1011646

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAP2_RS04750 (SAP2_09640)	-	1001279..1002004 (+)	726	WP_002509175.1	type 1 glutamine amidotransferase	-
SAP2_RS04755 (SAP2_09650)	-	1002495..1003481 (-)	987	WP_142019532.1	FUSC family protein	-
SAP2_RS04760 (SAP2_09660)	map	1003647..1004399 (+)	753	WP_021459027.1	type I methionyl aminopeptidase	-
SAP2_RS04765 (SAP2_09670)	-	1004502..1004888 (+)	387	WP_002509178.1	hypothetical protein	-
SAP2_RS04770 (SAP2_09680)	liaF	1004905..1005606 (+)	702	WP_002509179.1	cell wall-active antibiotics response protein LiaF	-
SAP2_RS04775 (SAP2_09690)	vraS	1005603..1006646 (+)	1044	WP_002509180.1	sensor histidine kinase	Regulator
SAP2_RS04780 (SAP2_09700)	vraR	1006636..1007265 (+)	630	WP_002509181.1	response regulator transcription factor	Regulator
SAP2_RS04785 (SAP2_09710)	-	1007326..1008405 (-)	1080	WP_142019533.1	YihY/virulence factor BrkB family protein	-
SAP2_RS04790 (SAP2_09720)	-	1008685..1008969 (-)	285	WP_002509183.1	hypothetical protein	-
SAP2_RS04795 (SAP2_09730)	-	1008976..1009440 (-)	465	WP_142019534.1	low molecular weight protein-tyrosine-phosphatase	-
SAP2_RS04800 (SAP2_09740)	-	1009576..1009779 (+)	204	WP_142019535.1	DUF1128 family protein	-
SAP2_RS04805 (SAP2_09750)	-	1009791..1011029 (+)	1239	WP_112369296.1	aminopeptidase	-
SAP2_RS04810 (SAP2_09760)	-	1011069..1011590 (+)	522	WP_142019536.1	acyl-CoA thioesterase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39859.16 Da
• Isoelectric Point: 5.2631

>NTDB_id=73305 SAP2_RS04775 WP_002509180.1 1005603..1006646(+) (vraS) [Staphylococcus arlettae strain P2]
MNHYIRAIGSMLILVYSTLIAFFFIDKIFVNIMYFQGMFYTQIFGIPVFLFLNLLIILLCIIVGSVLAYKINQQNHWLQT
QIERSIEGETVGINDQDIELYNETIELYQTLVPLNQEVHKLRMKTQNLTNESYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESQLTPPLDQQIPTLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVVDLQKKVPMKVIHDI
EDFTVPKGIEDHLFRITQEAISNTLRHSNGTKVTIELFNQEAYLLLRIQDNGIGFNVDDKAEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLDKEDIDAN

Nucleotide

• Length: 1044 bp

>NTDB_id=73305 SAP2_RS04775 WP_002509180.1 1005603..1006646(+) (vraS) [Staphylococcus arlettae strain P2]
ATGAATCACTACATTAGAGCAATAGGCTCTATGCTAATATTAGTATATAGTACATTAATTGCTTTTTTCTTTATAGATAA
AATATTTGTAAATATTATGTATTTTCAAGGTATGTTTTATACCCAAATATTTGGTATTCCAGTATTTTTATTTTTAAATT
TGCTCATAATTTTATTATGTATCATTGTAGGATCGGTTTTAGCTTATAAAATAAACCAGCAAAACCATTGGCTACAAACA
CAAATTGAACGTTCAATTGAAGGAGAAACAGTAGGGATTAATGACCAAGATATAGAACTTTATAATGAAACTATAGAGCT
CTATCAAACGTTAGTTCCACTCAATCAAGAAGTACATAAACTGCGAATGAAGACCCAAAATTTAACAAATGAATCTTATA
ATTTAAACGATGTCAAAGTTAAAAAAATAATCGAAGATGAACGACAAAGATTGGCTAGGGAATTACATGATTCAGTGAGT
CAGCAACTTTTTGCAGCTAGCATGATGTTATCAGCTATCAAAGAATCCCAATTAACACCACCGTTAGATCAACAAATCCC
TACATTAGAAAAAATGGTACAAGATTCTCAACTAGAAATGAGAGCATTATTACTACATTTAAGACCAATTGGTTTAAAAG
ATAAGTCTCTCGGCGAAGGTATTAAAGATTTAGTTGTCGATTTACAGAAAAAAGTACCAATGAAGGTCATACATGATATT
GAAGATTTTACTGTACCTAAAGGTATTGAAGATCATTTGTTTCGTATTACGCAAGAAGCGATATCCAATACATTACGTCA
TTCCAACGGTACAAAAGTAACAATTGAATTATTTAATCAAGAAGCATATTTATTATTACGTATTCAAGATAACGGTATTG
GTTTTAACGTAGATGATAAAGCTGAACAAAGTTATGGATTGAAAAATATGCGGGAGCGTGCATTAGAAATAGGTGCCACA
TTCCATATTGTATCGCTGCCTGATTCAGGTACTAGAATAGAAGTGAAAGCACCATTAGATAAGGAGGATATAGATGCCAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A7V7SQH4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	88.63	98.847	0.876