Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraS   Type   Regulator
Locus tag   N4T05_RS09855 Genome accession   NZ_CP104559
Coordinates   1984773..1985816 (-) Length   347 a.a.
NCBI ID   WP_001017131.1    Uniprot ID   A0A0D1IMN4
Organism   Staphylococcus aureus strain SA2107     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1962688..1985408 1984773..1985816 flank -635


Gene organization within MGE regions


Location: 1962688..1985816
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  N4T05_RS09645 (N4T05_09645) rinB 1962784..1962957 (-) 174 WP_024937262.1 transcriptional activator RinB -
  N4T05_RS09650 (N4T05_09650) - 1962950..1963186 (-) 237 WP_000483477.1 hypothetical protein -
  N4T05_RS09655 (N4T05_09655) - 1963211..1963444 (-) 234 WP_031905176.1 DUF1381 domain-containing protein -
  N4T05_RS09660 (N4T05_09660) - 1963613..1963858 (-) 246 WP_031905177.1 hypothetical protein -
  N4T05_RS09665 (N4T05_09665) - 1963895..1964428 (-) 534 WP_048525261.1 dUTP diphosphatase -
  N4T05_RS09670 (N4T05_09670) - 1964421..1964669 (-) 249 WP_031905179.1 DUF1024 family protein -
  N4T05_RS09675 (N4T05_09675) - 1964662..1964971 (-) 310 Protein_1867 hypothetical protein -
  N4T05_RS09680 (N4T05_09680) - 1964968..1965315 (-) 348 WP_000982695.1 YopX family protein -
  N4T05_RS09685 (N4T05_09685) - 1965379..1965627 (-) 249 WP_001126839.1 phi PVL orf 51-like protein -
  N4T05_RS09690 (N4T05_09690) - 1965628..1965987 (-) 360 Protein_1870 SA1788 family PVL leukocidin-associated protein -
  N4T05_RS09695 (N4T05_09695) - 1965988..1966173 (-) 186 WP_001187249.1 DUF3113 family protein -
  N4T05_RS09700 (N4T05_09700) - 1966178..1966582 (-) 405 WP_000049776.1 DUF1064 domain-containing protein -
  N4T05_RS09705 (N4T05_09705) - 1966592..1966813 (-) 222 WP_001123680.1 DUF3269 family protein -
  N4T05_RS09710 (N4T05_09710) - 1966826..1966987 (-) 162 WP_000237153.1 hypothetical protein -
  N4T05_RS09715 (N4T05_09715) - 1966981..1967760 (-) 780 WP_000803056.1 ATP-binding protein -
  N4T05_RS09720 (N4T05_09720) - 1967772..1968515 (-) 744 WP_000139436.1 conserved phage C-terminal domain-containing protein -
  N4T05_RS09725 (N4T05_09725) - 1968508..1969272 (-) 765 WP_000240900.1 AP2 domain-containing protein -
  N4T05_RS09730 (N4T05_09730) - 1969272..1969941 (-) 670 Protein_1878 putative HNHc nuclease -
  N4T05_RS09735 (N4T05_09735) ssbA 1969955..1970383 (-) 429 WP_124760935.1 single-stranded DNA-binding protein Machinery gene
  N4T05_RS09740 (N4T05_09740) - 1970383..1971006 (-) 624 WP_000139720.1 DUF1071 domain-containing protein -
  N4T05_RS09745 (N4T05_09745) - 1970999..1971220 (-) 222 WP_001077280.1 DUF2483 family protein -
  N4T05_RS09750 (N4T05_09750) - 1971230..1971490 (-) 261 WP_000291090.1 DUF1108 family protein -
  N4T05_RS09755 (N4T05_09755) - 1971587..1971748 (-) 162 WP_000066011.1 DUF1270 domain-containing protein -
  N4T05_RS09760 (N4T05_09760) - 1971741..1971962 (-) 222 WP_000594789.1 hypothetical protein -
  N4T05_RS09765 (N4T05_09765) - 1972033..1972263 (+) 231 WP_000395455.1 hypothetical protein -
  N4T05_RS09770 (N4T05_09770) - 1972445..1972639 (-) 195 WP_001148857.1 hypothetical protein -
  N4T05_RS09775 (N4T05_09775) - 1972656..1973420 (-) 765 WP_031880731.1 phage antirepressor KilAC domain-containing protein -
  N4T05_RS09780 (N4T05_09780) - 1973420..1973614 (-) 195 WP_000108121.1 helix-turn-helix transcriptional regulator -
  N4T05_RS09785 (N4T05_09785) - 1973877..1974209 (+) 333 WP_001055142.1 helix-turn-helix domain-containing protein -
  N4T05_RS09790 (N4T05_09790) - 1974226..1974900 (+) 675 WP_000775189.1 ImmA/IrrE family metallo-endopeptidase -
  N4T05_RS09795 (N4T05_09795) - 1974929..1975654 (+) 726 WP_000661378.1 PH domain-containing protein -
  N4T05_RS09800 (N4T05_09800) - 1975871..1976803 (+) 933 WP_000392183.1 hypothetical protein -
  N4T05_RS09805 (N4T05_09805) - 1976783..1976962 (-) 180 WP_000337827.1 hypothetical protein -
  N4T05_RS09810 (N4T05_09810) - 1977075..1978121 (+) 1047 WP_001145722.1 tyrosine-type recombinase/integrase -
  N4T05_RS09815 (N4T05_09815) yfkAB 1978166..1979311 (+) 1146 WP_001622132.1 radical SAM/CxCxxxxC motif protein YfkAB -
  N4T05_RS09820 (N4T05_09820) - 1979574..1980104 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  N4T05_RS09825 (N4T05_09825) - 1980194..1981441 (-) 1248 WP_000656302.1 aminopeptidase -
  N4T05_RS09830 (N4T05_09830) - 1981453..1981653 (-) 201 WP_000180459.1 DUF1128 family protein -
  N4T05_RS09835 (N4T05_09835) - 1981800..1982264 (+) 465 WP_000228668.1 low molecular weight protein-tyrosine-phosphatase -
  N4T05_RS09840 (N4T05_09840) - 1982271..1982546 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  N4T05_RS09845 (N4T05_09845) - 1982824..1984041 (+) 1218 WP_000037083.1 YihY/virulence factor BrkB family protein -
  N4T05_RS09850 (N4T05_09850) vraR 1984154..1984783 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  N4T05_RS09855 (N4T05_09855) vraS 1984773..1985816 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator

Sequence

Protein


Download         Length: 347 a.a.        Molecular weight: 40044.52 Da        Isoelectric Point: 6.0577

>NTDB_id=730577 N4T05_RS09855 WP_001017131.1 1984773..1985816(-) (vraS) [Staphylococcus aureus strain SA2107]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide


Download         Length: 1044 bp        

>NTDB_id=730577 N4T05_RS09855 WP_001017131.1 1984773..1985816(-) (vraS) [Staphylococcus aureus strain SA2107]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(249-340)

Histidine kinase (HisKA_3)

(147-210)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0D1IMN4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraS Staphylococcus aureus N315

100

100

1