Detailed information NTG0729856

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: N2W57_RS09620
• Genome accession: NZ_CP104476
• Coordinates: 1948758..1949801 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain DSM 20231-Res2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1943758..1954801

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
N2W57_RS09590 (N2W57_09590)	-	1944176..1945432 (-)	1257	WP_001795438.1	aminopeptidase	-
N2W57_RS09595 (N2W57_09595)	-	1945435..1945635 (-)	201	WP_000180461.1	DUF1128 family protein	-
N2W57_RS09600 (N2W57_09600)	-	1945782..1946246 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
N2W57_RS09605 (N2W57_09605)	-	1946253..1946528 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
N2W57_RS09610 (N2W57_09610)	-	1946806..1948023 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
N2W57_RS09615 (N2W57_09615)	vraR	1948139..1948768 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
N2W57_RS09620 (N2W57_09620)	vraS	1948758..1949801 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
N2W57_RS09625 (N2W57_09625)	liaF	1949798..1950499 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
N2W57_RS09630 (N2W57_09630)	-	1950514..1950900 (-)	387	WP_001110179.1	hypothetical protein	-
N2W57_RS09635 (N2W57_09635)	map	1951117..1951875 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
N2W57_RS09640 (N2W57_09640)	-	1952403..1953389 (+)	987	WP_000999713.1	FUSC family protein	-
N2W57_RS09645 (N2W57_09645)	-	1953879..1954292 (-)	414	WP_001549145.1	hypothetical protein	-
N2W57_RS09650 (N2W57_09650)	-	1954321..1954431 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=729856 N2W57_RS09620 WP_001017131.1 1948758..1949801(-) (vraS) [Staphylococcus aureus strain DSM 20231-Res2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=729856 N2W57_RS09620 WP_001017131.1 1948758..1949801(-) (vraS) [Staphylococcus aureus strain DSM 20231-Res2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1