Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   C11O2_RS06215 Genome accession   NZ_AP019548
Coordinates   1201239..1203521 (+) Length   760 a.a.
NCBI ID   WP_010922489.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 10-85     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1145312..1203521 1201239..1203521 within 0


Gene organization within MGE regions


Location: 1145312..1203521
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C11O2_RS05875 (A85_10830) - 1145312..1146424 (-) 1113 WP_001842570.1 recombinase family protein -
  C11O2_RS05880 (A85_10840) - 1146553..1147188 (-) 636 WP_000207454.1 CpXC domain-containing protein -
  C11O2_RS05885 (A85_10850) - 1147320..1148999 (-) 1680 Protein_1088 ComEC/Rec2 family competence protein -
  C11O2_RS05890 (A85_10860) - 1148980..1149642 (-) 663 WP_002983967.1 ComEA family DNA-binding protein -
  C11O2_RS05895 (A85_10870) - 1149842..1150582 (-) 741 WP_011285604.1 lysophospholipid acyltransferase family protein -
  C11O2_RS05900 (A85_10880) - 1150700..1151476 (+) 777 WP_010922438.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  C11O2_RS05905 (A85_10890) - 1151466..1151744 (+) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  C11O2_RS05910 (A85_10900) - 1151768..1153768 (-) 2001 WP_010922439.1 potassium transporter Kup -
  C11O2_RS05915 (A85_10910) - 1153896..1155515 (-) 1620 WP_002989158.1 DEAD/DEAH box helicase -
  C11O2_RS05920 (A85_10920) - 1155822..1157366 (-) 1545 WP_002989155.1 peptide chain release factor 3 -
  C11O2_RS05930 (A85_10930) - 1157614..1158309 (-) 696 WP_011285607.1 TIGR02206 family membrane protein -
  C11O2_RS05935 (A85_10940) - 1158389..1159780 (-) 1392 WP_010922441.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  C11O2_RS05940 (A85_10950) - 1159971..1161017 (-) 1047 WP_002989146.1 D-alanine--D-alanine ligase -
  C11O2_RS05945 (A85_10960) recR 1161118..1161714 (-) 597 WP_002983939.1 recombination mediator RecR -
  C11O2_RS09300 (A85_10970) - 1161761..1161952 (-) 192 WP_011285608.1 hypothetical protein -
  C11O2_RS05955 (A85_10980) - 1162513..1163292 (-) 780 WP_002989141.1 formate/nitrite transporter family protein -
  C11O2_RS05960 (A85_10990) - 1163416..1163958 (-) 543 WP_002989140.1 hypothetical protein -
  C11O2_RS05965 (A85_11000) - 1164119..1164640 (-) 522 WP_002983930.1 transcription repressor NadR -
  C11O2_RS05970 (A85_11010) - 1164747..1165442 (-) 696 WP_002983928.1 phosphoglycerate mutase -
  C11O2_RS05975 (A85_11020) - 1165681..1166616 (+) 936 WP_010922443.1 dihydroorotate oxidase -
  C11O2_RS05980 (A85_11040) - 1166916..1168778 (-) 1863 WP_011285610.1 heavy metal translocating P-type ATPase -
  C11O2_RS05985 (A85_11050) prx 1169309..1169491 (-) 183 WP_011017964.1 hypothetical protein Regulator
  C11O2_RS05990 (A85_11060) sda3 1169730..1170530 (+) 801 WP_011285611.1 streptodornase Sda3 -
  C11O2_RS05995 (A85_11070) - 1170801..1171235 (+) 435 WP_011017966.1 hypothetical protein -
  C11O2_RS06000 (A85_11080) - 1171305..1172510 (-) 1206 WP_010922446.1 glucosaminidase domain-containing protein -
  C11O2_RS06005 (A85_11090) - 1172626..1172853 (-) 228 WP_003058873.1 phage holin -
  C11O2_RS06010 (A85_11100) - 1172850..1173125 (-) 276 WP_002987582.1 hypothetical protein -
  C11O2_RS06015 (A85_11110) - 1173135..1173431 (-) 297 Protein_1113 hypothetical protein -
  C11O2_RS06020 (A85_11120) - 1173422..1173784 (-) 363 Protein_1114 phage tail protein -
  C11O2_RS06025 (A85_11130) - 1173777..1174241 (-) 465 WP_142235930.1 capsid assembly scaffolding protein Gp46 family protein -
  C11O2_RS06030 (A85_11140) - 1174322..1175365 (-) 1044 Protein_1116 terminase -
  C11O2_RS06035 (A85_11150) - 1175368..1175622 (-) 255 Protein_1117 hypothetical protein -
  C11O2_RS06040 (A85_11160) - 1175619..1175975 (-) 357 WP_002994106.1 hypothetical protein -
  C11O2_RS06045 (A85_11170) - 1176124..1176468 (-) 345 WP_010922469.1 HNH endonuclease signature motif containing protein -
  C11O2_RS06050 (A85_11180) - 1176577..1176996 (-) 420 WP_010922470.1 DUF1492 domain-containing protein -
  C11O2_RS06055 (A85_11190) - 1177264..1177899 (-) 636 WP_010922070.1 N-6 DNA methylase -
  C11O2_RS06060 - 1177901..1178110 (-) 210 WP_415245494.1 hypothetical protein -
  C11O2_RS09205 - 1178093..1178314 (-) 222 Protein_1123 transcriptional regulator -
  C11O2_RS06065 (A85_11210) - 1178414..1178599 (-) 186 WP_011285628.1 hypothetical protein -
  C11O2_RS06070 (A85_11220) - 1178601..1178912 (-) 312 WP_002990080.1 hypothetical protein -
  C11O2_RS06075 (A85_11230) - 1178990..1179175 (-) 186 WP_011054585.1 helix-turn-helix domain-containing protein -
  C11O2_RS06080 (A85_11240) - 1179342..1179581 (+) 240 WP_011284879.1 hypothetical protein -
  C11O2_RS06085 (A85_11250) - 1179723..1180529 (+) 807 WP_011285629.1 TIGR02391 family protein -
  C11O2_RS06090 (A85_11260) - 1180464..1180730 (-) 267 WP_010922204.1 hypothetical protein -
  C11O2_RS06095 (A85_11270) - 1180762..1181478 (-) 717 WP_011285630.1 phage antirepressor KilAC domain-containing protein -
  C11O2_RS06100 (A85_11280) - 1181490..1181681 (-) 192 WP_002993390.1 hypothetical protein -
  C11O2_RS06105 - 1182317..1182412 (+) 96 WP_020837421.1 type I toxin-antitoxin system Fst family toxin -
  C11O2_RS06110 (A85_11290) - 1182835..1183182 (+) 348 WP_011285631.1 helix-turn-helix domain-containing protein -
  C11O2_RS06115 (A85_11300) - 1183186..1183566 (+) 381 WP_002994744.1 ImmA/IrrE family metallo-endopeptidase -
  C11O2_RS06120 (A85_11310) - 1183578..1183844 (+) 267 WP_011285632.1 DUF4177 domain-containing protein -
  C11O2_RS06125 (A85_11320) - 1183968..1185110 (+) 1143 WP_003051793.1 tyrosine-type recombinase/integrase -
  C11O2_RS06130 (A85_11330) - 1185200..1185475 (-) 276 WP_002983920.1 HU family DNA-binding protein -
  C11O2_RS06135 (A85_11340) - 1185574..1186161 (-) 588 WP_010922482.1 YpmS family protein -
  C11O2_RS06140 (A85_11350) - 1186139..1186981 (-) 843 WP_002992620.1 SGNH/GDSL hydrolase family protein -
  C11O2_RS06145 (A85_11360) - 1186974..1187813 (-) 840 WP_002989125.1 DegV family protein -
  C11O2_RS06150 (A85_11370) - 1188041..1188982 (-) 942 WP_011285633.1 LPXTG cell wall anchor domain-containing protein -
  C11O2_RS06155 (A85_11380) recN 1189154..1190815 (-) 1662 WP_010922485.1 DNA repair protein RecN -
  C11O2_RS06160 (A85_11390) - 1190837..1191307 (-) 471 WP_002983907.1 arginine repressor -
  C11O2_RS06165 (A85_11400) - 1191294..1192121 (-) 828 WP_003056952.1 TlyA family rRNA (cytidine-2'-O)-methyltransferase -
  C11O2_RS06170 (A85_11410) - 1192114..1192986 (-) 873 WP_003056941.1 polyprenyl synthetase family protein -
  C11O2_RS06175 (A85_11420) - 1192986..1193201 (-) 216 WP_002983901.1 exodeoxyribonuclease VII small subunit -
  C11O2_RS06180 (A85_11430) xseA 1193179..1194519 (-) 1341 WP_002992349.1 exodeoxyribonuclease VII large subunit -
  C11O2_RS06185 (A85_11440) - 1194672..1195526 (-) 855 WP_010922486.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  C11O2_RS06190 (A85_11450) - 1195734..1197428 (-) 1695 WP_002989112.1 phospho-sugar mutase -
  C11O2_RS06195 (A85_11460) - 1197606..1199015 (-) 1410 WP_010922487.1 cryptochrome/photolyase family protein -
  C11O2_RS06200 (A85_11470) - 1199164..1199898 (-) 735 WP_010922488.1 amino acid ABC transporter ATP-binding protein -
  C11O2_RS06205 (A85_11480) - 1199898..1200584 (-) 687 WP_002983887.1 amino acid ABC transporter permease -
  C11O2_RS06210 (A85_11490) - 1200711..1200941 (-) 231 WP_002983885.1 YkuJ family protein -
  C11O2_RS06215 (A85_11500) clpE 1201239..1203521 (+) 2283 WP_010922489.1 ATP-dependent Clp protease ATP-binding subunit Regulator

Sequence

Protein


Download         Length: 760 a.a.        Molecular weight: 84732.90 Da        Isoelectric Point: 5.0123

>NTDB_id=72887 C11O2_RS06215 WP_010922489.1 1201239..1203521(+) (clpE) [Streptococcus pyogenes strain 10-85]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYIGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide


Download         Length: 2283 bp        

>NTDB_id=72887 C11O2_RS06215 WP_010922489.1 1201239..1203521(+) (clpE) [Streptococcus pyogenes strain 10-85]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTGCCAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTGTTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCGTTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGTGGTGAGTT
GCAACTCGTTGGTGCTACTACATTAAATGAATACCGTATTATTGAAAAAGACGCTGCCTTAGAACGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCCGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGACCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCCATCATTACTGAAAAAACCATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGGGACTTAAAAGAAAAGGAACAGTCTCAACTCGTAAACTTAGCCAATG
ATCTGAAAGCACACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCTTATTCGTTGGACCGACTGGGGTTGGTAAAACTGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATATCGGCTATGAAGAAGCTGGACAGCTAACCGAACAAGTTCGTCGCAATCCATAT
TCACTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGATGGCCG
TTTAACAGATGGTCAAGGACGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAGCATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGGCCGCTCCGTCGTACTATTCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAATATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTCGATTAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(300-397)

AAA domain (Cdc48 subfamily) (AAA_2)

(485-648)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(656-729)

ATPase family associated with various cellular activities (AAA) (AAA)

(162-281)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.626

98.421

0.833
  clpE Streptococcus pneumoniae Rx1

82.557

98.816

0.816
  clpE Streptococcus pneumoniae D39

82.557

98.816

0.816
  clpE Streptococcus pneumoniae R6

82.557

98.816

0.816
  clpE Streptococcus pneumoniae TIGR4

82.423

98.816

0.814
  clpC Lactococcus lactis subsp. cremoris KW2

75.033

100

0.751
  clpC Bacillus subtilis subsp. subtilis str. 168

51.442

86.711

0.446
  clpC Streptococcus pneumoniae D39

47.68

82.237

0.392
  clpC Streptococcus pneumoniae Rx1

47.68

82.237

0.392
  clpC Streptococcus pneumoniae TIGR4

47.68

82.237

0.392
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

45.846

85.526

0.392
  clpC Streptococcus mutans UA159

47.411

81.316

0.386
  clpC Streptococcus thermophilus LMD-9

46.955

82.105

0.386
  clpC Streptococcus thermophilus LMG 18311

46.635

82.105

0.383

Multiple sequence alignment