Detailed information NTG0072745

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GDK21_RS10235
• Genome accession: NZ_AP019542
• Coordinates: 2040483..2041526 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain KG-03
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2035483..2046526

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GDK21_RS10205 (SAKG03_18720)	-	2035904..2037160 (-)	1257	WP_001795108.1	aminopeptidase	-
GDK21_RS10210 (SAKG03_18730)	-	2037163..2037363 (-)	201	WP_000180460.1	DUF1128 family protein	-
GDK21_RS10215 (SAKG03_18740)	-	2037510..2037974 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
GDK21_RS10220 (SAKG03_18750)	-	2037981..2038256 (+)	276	WP_117195002.1	YtxH domain-containing protein	-
GDK21_RS10225 (SAKG03_18760)	-	2038534..2039751 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
GDK21_RS10230 (SAKG03_18770)	vraR	2039864..2040493 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
GDK21_RS10235 (SAKG03_18780)	vraS	2040483..2041526 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
GDK21_RS10240 (SAKG03_18790)	liaF	2041523..2042224 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
GDK21_RS10245 (SAKG03_18800)	-	2042239..2042625 (-)	387	WP_001110179.1	hypothetical protein	-
GDK21_RS10250 (SAKG03_18810)	map	2042842..2043600 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
GDK21_RS10255 (SAKG03_18820)	-	2044131..2045117 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
GDK21_RS10260 (SAKG03_18830)	-	2045548..2045961 (-)	414	WP_001557448.1	hypothetical protein	-
GDK21_RS10265	-	2045990..2046100 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=72745 GDK21_RS10235 WP_001017131.1 2040483..2041526(-) (vraS) [Staphylococcus aureus strain KG-03]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=72745 GDK21_RS10235 WP_001017131.1 2040483..2041526(-) (vraS) [Staphylococcus aureus strain KG-03]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1