Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   N2A96_RS04375 Genome accession   NZ_CP104047
Coordinates   833958..836066 (-) Length   702 a.a.
NCBI ID   WP_003105519.1    Uniprot ID   A0A854WD63
Organism   Streptococcus parauberis strain KSP10     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 807074..867391 833958..836066 within 0


Gene organization within MGE regions


Location: 807074..867391
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  N2A96_RS04245 (N2A96_04245) - 808371..808991 (+) 621 WP_037619847.1 glucosaminidase domain-containing protein -
  N2A96_RS04250 (N2A96_04250) - 809132..809935 (+) 804 WP_003106599.1 glycoside hydrolase family 73 protein -
  N2A96_RS04255 (N2A96_04255) - 809995..810516 (+) 522 WP_003106600.1 hypothetical protein -
  N2A96_RS04260 (N2A96_04260) - 810590..810970 (+) 381 WP_003103937.1 DUF1149 family protein -
  N2A96_RS04265 (N2A96_04265) - 810970..811818 (+) 849 WP_003104962.1 DegV family protein -
  N2A96_RS04270 (N2A96_04270) dapB 811836..812603 (+) 768 WP_003105813.1 4-hydroxy-tetrahydrodipicolinate reductase -
  N2A96_RS04275 (N2A96_04275) - 812600..813811 (+) 1212 WP_003102825.1 CCA tRNA nucleotidyltransferase -
  N2A96_RS04280 (N2A96_04280) - 813804..815681 (+) 1878 WP_003106601.1 ABC-F family ATP-binding cassette domain-containing protein -
  N2A96_RS04285 (N2A96_04285) - 815685..816158 (+) 474 WP_003105038.1 GNAT family N-acetyltransferase -
  N2A96_RS04290 (N2A96_04290) - 816261..817997 (+) 1737 WP_003102488.1 ABC transporter ATP-binding protein -
  N2A96_RS04295 (N2A96_04295) - 817997..819766 (+) 1770 WP_003106602.1 ABC transporter ATP-binding protein -
  N2A96_RS04300 (N2A96_04300) gdhA 819897..821243 (+) 1347 WP_003106603.1 NADP-specific glutamate dehydrogenase -
  N2A96_RS04305 (N2A96_04305) - 821309..821719 (+) 411 WP_003106604.1 peptide deformylase -
  N2A96_RS04310 (N2A96_04310) - 821757..821942 (-) 186 WP_003102863.1 hypothetical protein -
  N2A96_RS04315 (N2A96_04315) - 821948..822976 (+) 1029 Protein_799 ABC transporter ATP-binding protein -
  N2A96_RS04320 (N2A96_04320) mvk 823139..824017 (+) 879 WP_003106606.1 mevalonate kinase -
  N2A96_RS04325 (N2A96_04325) mvaD 823999..824934 (+) 936 WP_003104536.1 diphosphomevalonate decarboxylase -
  N2A96_RS04330 (N2A96_04330) - 824935..825936 (+) 1002 WP_003104029.1 phosphomevalonate kinase -
  N2A96_RS04335 (N2A96_04335) fni 825936..826931 (+) 996 WP_003106607.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  N2A96_RS04340 (N2A96_04340) - 826994..828277 (-) 1284 WP_003106609.1 hydroxymethylglutaryl-CoA reductase, degradative -
  N2A96_RS04345 (N2A96_04345) - 828274..829440 (-) 1167 WP_003104825.1 hydroxymethylglutaryl-CoA synthase -
  N2A96_RS04350 (N2A96_04350) - 829632..830471 (+) 840 WP_003106617.1 thymidylate synthase -
  N2A96_RS04355 (N2A96_04355) - 830548..831063 (+) 516 WP_003106618.1 dihydrofolate reductase -
  N2A96_RS04360 (N2A96_04360) clpX 831268..832497 (+) 1230 WP_003103169.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  N2A96_RS04365 (N2A96_04365) yihA 832506..833105 (+) 600 WP_003106619.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  N2A96_RS04370 (N2A96_04370) - 833270..833935 (+) 666 WP_003106620.1 hypothetical protein -
  N2A96_RS04375 (N2A96_04375) clpC 833958..836066 (-) 2109 WP_003105519.1 AAA family ATPase Regulator
  N2A96_RS04380 (N2A96_04380) rplJ 836517..837017 (+) 501 WP_003104757.1 50S ribosomal protein L10 -
  N2A96_RS04385 (N2A96_04385) rplL 837083..837448 (+) 366 WP_003103838.1 50S ribosomal protein L7/L12 -
  N2A96_RS04395 (N2A96_04395) - 838137..838991 (+) 855 WP_003106628.1 replication initiator protein A -
  N2A96_RS04400 (N2A96_04400) - 838988..839149 (+) 162 WP_003104080.1 hypothetical protein -
  N2A96_RS10570 - 839546..839632 (+) 87 WP_375543854.1 YSIRK-type signal peptide-containing protein -
  N2A96_RS04410 (N2A96_04410) - 841049..842611 (+) 1563 WP_003106629.1 hypothetical protein -
  N2A96_RS04415 (N2A96_04415) - 842698..843072 (+) 375 WP_003106630.1 hypothetical protein -
  N2A96_RS04420 (N2A96_04420) - 843023..843556 (+) 534 WP_003106631.1 YdbC family protein -
  N2A96_RS04425 (N2A96_04425) - 843613..843837 (+) 225 WP_003104561.1 hypothetical protein -
  N2A96_RS04430 (N2A96_04430) - 843858..844589 (+) 732 WP_003106632.1 type IV secretion system protein -
  N2A96_RS04435 (N2A96_04435) - 844637..844942 (+) 306 WP_003106633.1 hypothetical protein -
  N2A96_RS04440 (N2A96_04440) - 845016..845366 (+) 351 WP_233847601.1 PrgI family protein -
  N2A96_RS04445 (N2A96_04445) - 845326..847792 (+) 2467 Protein_825 VirB4-like conjugal transfer ATPase, CD1110 family -
  N2A96_RS04450 (N2A96_04450) - 847807..850398 (+) 2592 WP_259976739.1 phage tail tip lysozyme -
  N2A96_RS04455 (N2A96_04455) - 850415..851050 (+) 636 WP_003106642.1 hypothetical protein -
  N2A96_RS04460 (N2A96_04460) - 851076..851351 (+) 276 WP_003104435.1 hypothetical protein -
  N2A96_RS04465 (N2A96_04465) - 851335..852198 (+) 864 WP_003106643.1 hypothetical protein -
  N2A96_RS04470 (N2A96_04470) - 852231..852893 (+) 663 WP_003106647.1 LPXTG cell wall anchor domain-containing protein -
  N2A96_RS04475 (N2A96_04475) - 852965..853501 (+) 537 WP_003103611.1 hypothetical protein -
  N2A96_RS04480 (N2A96_04480) - 853502..855334 (+) 1833 WP_003106649.1 VirD4-like conjugal transfer protein, CD1115 family -
  N2A96_RS04485 (N2A96_04485) - 855409..855735 (+) 327 WP_003105373.1 hypothetical protein -
  N2A96_RS04490 (N2A96_04490) - 855780..857507 (+) 1728 WP_003106651.1 type IA DNA topoisomerase -
  N2A96_RS04495 (N2A96_04495) - 857508..861359 (+) 3852 WP_003106653.1 PBECR4 domain-containing protein -
  N2A96_RS04500 (N2A96_04500) - 861424..861684 (+) 261 WP_003103735.1 hypothetical protein -
  N2A96_RS04505 (N2A96_04505) mobC 861889..862260 (+) 372 WP_003105086.1 plasmid mobilization relaxosome protein MobC -
  N2A96_RS04510 (N2A96_04510) - 862264..863907 (+) 1644 WP_003106654.1 helical hairpin domain-containing protein -
  N2A96_RS04515 (N2A96_04515) - 863969..864103 (+) 135 WP_003105827.1 hypothetical protein -
  N2A96_RS04520 (N2A96_04520) - 864816..865106 (-) 291 WP_003106656.1 hypothetical protein -
  N2A96_RS04525 (N2A96_04525) - 865416..865799 (+) 384 Protein_841 type I restriction endonuclease -
  N2A96_RS04530 (N2A96_04530) - 865962..866417 (+) 456 WP_003106658.1 CopY/TcrY family copper transport repressor -
  N2A96_RS04535 (N2A96_04535) - 866460..866594 (+) 135 WP_142377571.1 heavy metal-associated domain-containing protein -

Sequence

Protein


Download         Length: 702 a.a.        Molecular weight: 77655.54 Da        Isoelectric Point: 4.8649

>NTDB_id=727304 N2A96_RS04375 WP_003105519.1 833958..836066(-) (clpC) [Streptococcus parauberis strain KSP10]
MTNYYGKDPFGSMDDIFNQLMGNTGGYQTENRRYLVNGREMTPEEFQEYRQTGKLSSTAPTQEQGYPQNQKEDGILNQLG
TNLTEEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVAGDVPAAIKNKEIISIDISGL
EAGTQYRGAFEENIQNLIKEVKEAGNVILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHNVILPDSVLKAAVDYSVQYIPQRSLPDKAIDLIDMTAAHLAA
QHPVTDLKSLETAIASEKDKQEKAVAAEDYELALQAKVRIEELQKQMANHTEGQKVTATINDVAESVERLTGVPVSNMGA
SDLERLKEIGNRLRGHVIGQDQAVQAVAKAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNQYTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTIDFKNT
VIIATSNAGFGNEALTGQEDHDQKIMDRIAPYFRPEFLNRFNGVIEFSHLEKKDLKEIVELMLTEVNQTINKKGITLEVT
EPVKEELIELGYDKAMGVRPLRRVIEQEIRDRITDYYLEHPDDKHLKANLADGQIVISKQDK

Nucleotide


Download         Length: 2109 bp        

>NTDB_id=727304 N2A96_RS04375 WP_003105519.1 833958..836066(-) (clpC) [Streptococcus parauberis strain KSP10]
ATGACAAACTATTATGGAAAAGACCCTTTTGGTAGCATGGATGACATTTTTAATCAATTGATGGGTAACACAGGCGGTTA
TCAAACTGAAAATCGTCGTTACCTAGTTAATGGGCGTGAAATGACACCTGAAGAATTTCAAGAATATCGACAAACTGGTA
AGCTCAGTTCTACTGCTCCTACTCAGGAACAAGGCTATCCCCAAAATCAAAAAGAAGATGGCATTCTAAACCAATTAGGT
ACCAACTTAACTGAAGAAGCACGACAAGGACACTTAGATCCAGTCATTGGACGAAATAAAGAAATTCAAGATACAGCTGA
AATATTAGCTCGCCGGACCAAGAACAATCCCGTTCTAGTAGGTGATGCGGGGGTTGGTAAAACAGCTGTGGTCGAAGGCT
TAGCCCAAGCTATCGTTGCTGGTGACGTCCCTGCTGCCATTAAAAACAAAGAAATTATTTCTATTGATATTTCCGGCTTA
GAAGCAGGTACTCAATACCGTGGTGCTTTTGAAGAAAATATTCAGAATTTAATTAAAGAAGTTAAAGAAGCCGGGAATGT
TATCCTCTTCTTTGATGAAATTCATCAAATTTTAGGCGCTGGCTCAACAGGTGGTGATTCTGGTTCCAAAGGCTTGGCCG
ATATTCTTAAACCAGCCCTATCTCGTGGCGAGTTGACCGTCATCGGTGCGACAACTCAAGATGAATATCGAAACACTATT
CTGAAAAATGCGGCCTTGGCTCGTCGTTTTAACGAAGTTAAAGTCAATGCGCCTTCTGCCGAAGATACCTTCCACATTTT
GATGGGTATCAGGAATCTTTATGAGCAACACCACAACGTCATTCTTCCGGATTCTGTTTTGAAAGCAGCCGTGGATTACT
CCGTTCAGTACATTCCACAGCGTAGTCTTCCAGATAAAGCCATCGATTTAATTGACATGACGGCTGCCCATTTAGCTGCG
CAACACCCAGTCACTGATTTGAAGAGTCTTGAAACAGCAATTGCTAGTGAGAAAGACAAGCAAGAAAAGGCTGTCGCTGC
AGAAGATTATGAGTTAGCCTTGCAAGCTAAAGTACGAATTGAAGAATTACAAAAGCAAATGGCAAACCATACCGAAGGTC
AAAAAGTGACCGCAACCATCAACGATGTCGCCGAATCAGTTGAACGTCTAACCGGCGTACCAGTTTCCAATATGGGCGCA
AGTGACTTAGAACGTTTGAAAGAAATTGGCAACCGACTTAGAGGACATGTCATCGGACAGGATCAAGCTGTTCAAGCAGT
CGCAAAGGCTATCCGTCGTAACCGTGCCGGCTTTGATGATGGCAATCGCCCAATTGGGTCATTCCTCTTTGTTGGTCCGA
CCGGCGTTGGTAAAACGGAATTAGCCAAACAGCTTGCGCTTGACATGTTTGGTTCCAAGGATGCGATCATTCGTTTAGAT
ATGTCAGAATACAGTGATCGCACTGCCGTTTCTAAATTGATTGGGACTACTGCTGGTTATGTTGGTTACGACGACAATCA
ATACACATTAACTGAACGTGTCCGTCGTAATCCATACTCAATTATTTTACTGGATGAAATTGAAAAAGCAGACCCACAAG
TCATTACCCTACTACTCCAAGTATTAGATGATGGTCGTTTAACTGATGGCCAAGGTAATACGATTGACTTCAAAAATACA
GTGATTATTGCTACATCTAATGCTGGTTTTGGCAATGAAGCATTAACGGGTCAAGAAGATCATGACCAAAAAATTATGGA
CCGAATCGCTCCTTATTTTAGACCTGAATTCTTAAATCGTTTTAATGGTGTGATTGAATTCTCACATCTAGAAAAAAAGG
ATTTGAAAGAAATTGTTGAATTAATGTTAACGGAAGTTAATCAAACAATCAATAAAAAAGGTATCACTTTAGAAGTAACA
GAACCTGTTAAAGAGGAACTAATTGAATTAGGATATGACAAAGCTATGGGAGTTAGACCATTACGCCGTGTCATTGAACA
AGAAATCCGTGACCGTATAACAGACTATTATTTGGAACATCCCGATGATAAACATCTAAAAGCAAATTTAGCAGATGGTC
AAATTGTGATTAGTAAACAAGACAAATGA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(259-353)

ATPase family associated with various cellular activities (AAA) (AAA)

(118-250)

AAA domain (Cdc48 subfamily) (AAA_2)

(443-602)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(610-680)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A854WD63

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Lactococcus lactis subsp. cremoris KW2

48.515

100

0.489
  clpE Streptococcus mutans UA159

47.532

100

0.48
  clpE Streptococcus pneumoniae Rx1

46.968

100

0.474
  clpE Streptococcus pneumoniae D39

46.968

100

0.474
  clpE Streptococcus pneumoniae R6

46.968

100

0.474
  clpE Streptococcus pneumoniae TIGR4

46.968

100

0.474
  clpC Bacillus subtilis subsp. subtilis str. 168

44.651

91.88

0.41
  clpC Streptococcus pneumoniae TIGR4

41.617

95.157

0.396
  clpC Streptococcus pneumoniae Rx1

41.617

95.157

0.396
  clpC Streptococcus pneumoniae D39

41.617

95.157

0.396
  clpC Streptococcus mutans UA159

40.399

92.735

0.375
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

41.842

88.177

0.369
  clpC Streptococcus thermophilus LMG 18311

41.44

89.031

0.369
  clpC Streptococcus thermophilus LMD-9

41.506

88.889

0.369