Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   P1Y72_RS03680 Genome accession   NZ_CP119599
Coordinates   782425..783066 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain 1133     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 777425..788066
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P1Y72_RS03655 (P1Y72_03655) comFA/cflA 777511..778836 (-) 1326 WP_159330814.1 DEAD/DEAH box helicase Machinery gene
  P1Y72_RS03660 (P1Y72_03660) - 778892..779524 (+) 633 WP_009880468.1 YigZ family protein -
  P1Y72_RS03665 (P1Y72_03665) cysK 779652..780593 (+) 942 WP_010922535.1 cysteine synthase A -
  P1Y72_RS03670 (P1Y72_03670) - 780611..780988 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  P1Y72_RS03675 (P1Y72_03675) - 780988..782388 (-) 1401 WP_011285657.1 Cof-type HAD-IIB family hydrolase -
  P1Y72_RS03680 (P1Y72_03680) vraR 782425..783066 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  P1Y72_RS03685 (P1Y72_03685) - 783059..784063 (-) 1005 WP_002991890.1 sensor histidine kinase -
  P1Y72_RS03690 (P1Y72_03690) liaF 784060..784752 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  P1Y72_RS03695 (P1Y72_03695) pknB 784875..786773 (-) 1899 WP_010922538.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  P1Y72_RS03700 (P1Y72_03700) - 786770..787510 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=727160 P1Y72_RS03680 WP_002983671.1 782425..783066(-) (vraR) [Streptococcus pyogenes strain 1133]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=727160 P1Y72_RS03680 WP_002983671.1 782425..783066(-) (vraR) [Streptococcus pyogenes strain 1133]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385