Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   P1K34_RS06685 Genome accession   NZ_CP119598
Coordinates   1349486..1350127 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain 1042     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1344486..1355127
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P1K34_RS06660 (P1K34_06660) comFA/cflA 1344573..1345898 (-) 1326 WP_136113647.1 DEAD/DEAH box helicase Machinery gene
  P1K34_RS06665 (P1K34_06665) - 1345953..1346585 (+) 633 WP_002983676.1 YigZ family protein -
  P1K34_RS06670 (P1K34_06670) cysK 1346713..1347654 (+) 942 WP_111676226.1 cysteine synthase A -
  P1K34_RS06675 (P1K34_06675) - 1347672..1348049 (-) 378 WP_032464495.1 S1 RNA-binding domain-containing protein -
  P1K34_RS06680 (P1K34_06680) - 1348049..1349449 (-) 1401 WP_276131600.1 Cof-type HAD-IIB family hydrolase -
  P1K34_RS06685 (P1K34_06685) vraR 1349486..1350127 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  P1K34_RS06690 (P1K34_06690) - 1350120..1351124 (-) 1005 WP_002991890.1 sensor histidine kinase -
  P1K34_RS06695 (P1K34_06695) liaF 1351121..1351813 (-) 693 WP_276131601.1 cell wall-active antibiotics response protein LiaF -
  P1K34_RS06700 (P1K34_06700) pknB 1351936..1353834 (-) 1899 WP_111676222.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  P1K34_RS06705 (P1K34_06705) - 1353831..1354571 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=727101 P1K34_RS06685 WP_002983671.1 1349486..1350127(-) (vraR) [Streptococcus pyogenes strain 1042]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=727101 P1K34_RS06685 WP_002983671.1 1349486..1350127(-) (vraR) [Streptococcus pyogenes strain 1042]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGGCGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385