Detailed information NTG0721160

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NF399_RS04495
• Genome accession: NZ_CP103049
• Coordinates: 926744..927790 (+)
• Length: 348 a.a.
• NCBI ID: WP_002435929.1
• Uniprot ID: A0A0S4MEI3
• Organism: Staphylococcus capitis subsp. capitis strain DSM 20326
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 921744..932790

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NF399_RS04465	-	921999..922724 (+)	726	WP_002453605.1	type 1 glutamine amidotransferase	-
NF399_RS04470	isaB	922956..923498 (+)	543	WP_002453604.1	immunodominant staphylococcal antigen IsaB family protein	-
NF399_RS04475	-	923581..924570 (-)	990	WP_049389121.1	FUSC family protein	-
NF399_RS04480	map	924745..925500 (+)	756	WP_002453602.1	type I methionyl aminopeptidase	-
NF399_RS04485	-	925645..926031 (+)	387	WP_002453601.1	hypothetical protein	-
NF399_RS04490	liaF	926046..926747 (+)	702	WP_002453600.1	cell wall-active antibiotics response protein LiaF	-
NF399_RS04495	vraS	926744..927790 (+)	1047	WP_002435929.1	sensor histidine kinase	Regulator
NF399_RS04500	vraR	927780..928409 (+)	630	WP_002453599.1	two-component system response regulator VraR	Regulator
NF399_RS04505	-	928475..929728 (-)	1254	WP_016898704.1	YihY/virulence factor BrkB family protein	-
NF399_RS04510	-	930065..930349 (-)	285	WP_002435890.1	hypothetical protein	-
NF399_RS04515	-	930356..930820 (-)	465	WP_002435947.1	low molecular weight protein-tyrosine-phosphatase	-
NF399_RS04520	-	930961..931167 (+)	207	WP_002435959.1	DUF1128 domain-containing protein	-
NF399_RS04525	-	931181..932422 (+)	1242	WP_002453597.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40136.57 Da
• Isoelectric Point: 6.0600

>NTDB_id=721160 NF399_RS04495 WP_002435929.1 926744..927790(+) (vraS) [Staphylococcus capitis subsp. capitis strain DSM 20326]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNILIILLCIIVGSVLAYKINQQNDWLKS
QIERSIEGETVGINDQNLELYSETLEIYHTLVPLNQELHRLRMKTQNMTNENYNMNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGSKVTVELFNKEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDESNGD

Nucleotide

• Length: 1047 bp

>NTDB_id=721160 NF399_RS04495 WP_002435929.1 926744..927790(+) (vraS) [Staphylococcus capitis subsp. capitis strain DSM 20326]
ATGAATCACTACTTGAGAGCAATTGGTTCAATGCTAATACTTGTATATAGCATGCTAACTGCTTTTTTATTCATTGATAA
GGTGTTCGTCAATATTATTTATTTTCAAGGGATGTTTTACACCCAAATTTTTGGAATACCAGTATTTTTATTCCTAAATA
TATTAATCATCTTACTATGTATTATCGTTGGCTCTGTGTTAGCGTATAAAATCAATCAACAAAATGATTGGCTTAAGTCA
CAAATTGAAAGGTCTATTGAAGGTGAAACAGTAGGCATAAATGATCAAAACCTAGAGTTATACAGTGAAACGTTAGAAAT
TTACCATACTTTAGTTCCTTTAAATCAAGAATTACACCGATTGAGAATGAAAACGCAGAATATGACCAATGAAAATTATA
ATATGAATGATGTAAAAGTGAAGAAAATTATTGAAGACGAACGTCAACGTTTAGCAAGAGAACTACATGACTCAGTTAGT
CAGCAACTATTTGCAGCAAGTATGATGTTGTCAGCGATTAAAGAGTCAAAATTAGAACCACCTTTAGACCAACAAATACC
TGTACTAGAGAAGATGGTTCAAGACTCTCAGCTCGAAATGAGAGCATTATTATTACATCTAAGACCTATTGGTTTGAAAG
ACAAATCATTAGGAGAGGGTATTAAAGATTTAGTCATTGATCTTCAAAAGAAAGTCCCTATGAAAGTTGTTCATGAAATT
CAAGATTTCAAAGTACCAAAAGGGATAGAAGATCATCTGTTTAGAATCACTCAAGAGGCTATTTCTAATACATTACGACA
CTCTAATGGTTCTAAGGTAACAGTTGAATTATTTAATAAAGAAGATTATTTACTACTTAGAATTCAAGATAATGGTAAAG
GTTTTAATGTAGATGAAAAATTTGAACAGAGTTATGGATTAAAAAATATGAGAGAACGTGCTTTAGAGATTGGTGCCACA
TTCCATATCGTATCGTTACCGGATTCAGGTACGAGAATAGAAGTTAAAGCACCATTGAATAAGGAGGATGAATCAAATGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A0S4MEI3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.586	98.563	0.922