Detailed information NTG0721048

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: PUW52_RS10230
• Genome accession: NZ_CP118078
• Coordinates: 2003398..2005959 (-)
• Length: 853 a.a.
• NCBI ID: WP_024053228.1
• Uniprot ID: A0ABS3GCR8
• Organism: Streptococcus anginosus strain VSI16
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1998398..2010959

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PUW52_RS10205 (PUW52_10205)	ruvA	1998514..1999104 (-)	591	WP_024053223.1	Holliday junction branch migration protein RuvA	Machinery gene
PUW52_RS10210 (PUW52_10210)	-	1999266..1999709 (+)	444	WP_024053224.1	helix-turn-helix transcriptional regulator	-
PUW52_RS10215 (PUW52_10215)	hexB	2000114..2002060 (-)	1947	WP_024053225.1	DNA mismatch repair endonuclease MutL	Machinery gene
PUW52_RS10220 (PUW52_10220)	-	2002314..2002754 (+)	441	WP_024053226.1	LytTR family DNA-binding domain-containing protein	-
PUW52_RS10225 (PUW52_10225)	-	2002751..2003209 (+)	459	WP_024053227.1	DUF3021 domain-containing protein	-
PUW52_RS10230 (PUW52_10230)	hexA	2003398..2005959 (-)	2562	WP_024053228.1	DNA mismatch repair protein MutS	Machinery gene
PUW52_RS10235 (PUW52_10235)	argR	2006328..2006768 (-)	441	WP_003027809.1	arginine repressor	-
PUW52_RS10240 (PUW52_10240)	argS	2006872..2008560 (+)	1689	WP_024053229.1	arginine--tRNA ligase	-
PUW52_RS10245 (PUW52_10245)	nrdI	2008615..2009070 (-)	456	WP_024053230.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
PUW52_RS10250 (PUW52_10250)	-	2009146..2009655 (-)	510	WP_024053231.1	hypothetical protein	-

Sequence

Protein

• Length: 853 a.a.
• Molecular weight: 96064.79 Da
• Isoelectric Point: 5.0391

>NTDB_id=721048 PUW52_RS10230 WP_024053228.1 2003398..2005959(-) (hexA) [Streptococcus anginosus strain VSI16]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDATNAAQILEIALTSRNKNSENPIPMAGVPYHSVQQYIDVLI
EAGYKVAIAEQMEDPKKAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVALDKLSGIYGLAYMDVGTGEFQVTSLSDFNI
VCGEIRNLRAREVVLGYELSEMERQVLETQMNLLLSQVETTFDDVQLLGKDLSPLERQVAGKLLQYVHKTQLRELSHLKQ
VHHYEIKDFLQMDYSTMASLDLIENARTGKKHGSLYWLMDETKTAMGTRLLRAWIQRPLIDKERIVKRQDVVQVFLDHFF
ERSDLSDSLKGVYDIERLASRVSFGKTNPKDLLQLAATLSHVPQIKGILKGIDSPVLEDLIAKLDEIPELASLIQSAISP
DAPNVITEGNIIKTGFDETLDKYRVVIRDGTSWIADIEAKEREASGINNLKIDYNKKDGYYFHVTNSQLEHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEAGKYIKRLQSLAQTMATVDVLQSFAAVAEKQHFVRPEFI
EQRSIQIDKGRHAVVEKVMGAQTYIPNSISMDENVNVQLITGPNMSGKSTYMRQLAIVVIMAQMGSYVSAESAQLPIFDA
IFTRIGAADDLVSGQSTFMIEMMEANHAISQATENSLILFDELGRGTATYDGMALAQAIIEYIHNRTGAKTLFATHYHEL
TELSTSLTQLENVHVATLEKDGQVTFLHKIEVGPADKSYGIHVAKIAGLPNDLLTRADQILTRLESQVNEKPSFGIFNTL
PADAREKNQVAEQMSLFTETTESPILDELRQLDIYNMTPMEVMLAVAEIKKKL

Nucleotide

• Length: 2562 bp

>NTDB_id=721048 PUW52_RS10230 WP_024053228.1 2003398..2005959(-) (hexA) [Streptococcus anginosus strain VSI16]
ATGACAAAAGAAAAACTATCTCCAGGAATGCAACAGTATTTAGATATAAAAAAAGATTATCCAGATGCTTTTTTGTTGTT
TCGCATGGGAGATTTTTATGAATTATTCTATGATGATGCGACCAATGCGGCACAGATTTTAGAGATTGCTCTGACTAGTC
GCAATAAAAACTCGGAAAATCCAATCCCAATGGCAGGAGTTCCTTACCATTCAGTGCAGCAATACATTGATGTTTTAATT
GAAGCAGGCTATAAAGTTGCGATTGCAGAGCAAATGGAAGATCCTAAAAAAGCGGTTGGAGTAGTCAAACGCGAAGTAGT
ACAGGTGATTACGCCGGGGACAGTAGTTGATTCTTCAAAACCAGACAGTCAGAATAACTTTTTAGTGGCTTTGGATAAGC
TGTCAGGTATATATGGACTGGCTTATATGGATGTGGGAACGGGTGAATTTCAGGTCACAAGTCTTAGTGACTTTAACATA
GTCTGTGGAGAAATCCGAAACCTGCGAGCGCGTGAAGTGGTCTTAGGGTATGAATTGTCTGAAATGGAGCGCCAAGTATT
GGAGACTCAAATGAATCTCCTTTTATCGCAAGTAGAAACTACATTTGATGATGTTCAGCTACTAGGAAAGGACTTGTCGC
CGCTAGAGCGCCAAGTAGCTGGAAAGTTATTACAGTATGTTCATAAAACGCAGCTACGTGAGCTTAGTCATTTGAAACAA
GTTCATCATTATGAAATCAAAGATTTCTTGCAGATGGACTACTCAACTATGGCAAGTCTGGATTTAATAGAGAATGCTCG
AACAGGAAAGAAGCACGGGAGCCTTTATTGGCTGATGGATGAGACTAAGACAGCTATGGGAACACGATTGTTGAGAGCGT
GGATTCAACGTCCGTTGATTGATAAAGAGCGGATCGTCAAGCGGCAGGATGTAGTGCAAGTCTTTTTAGATCATTTCTTT
GAGCGCAGTGACTTATCAGACAGTCTCAAAGGAGTGTATGATATTGAGCGTTTAGCCAGTCGGGTTTCGTTTGGCAAGAC
CAATCCGAAAGATCTATTACAACTTGCTGCGACATTGAGTCATGTGCCACAAATTAAGGGAATTTTAAAAGGAATTGATA
GCCCAGTTTTGGAAGATTTGATTGCAAAATTGGATGAAATTCCTGAACTGGCGTCCTTAATTCAGTCAGCAATTTCGCCG
GATGCTCCAAATGTCATTACAGAGGGTAATATTATTAAAACAGGTTTTGATGAAACCTTGGATAAATATCGAGTGGTTAT
ACGAGATGGAACGAGCTGGATTGCAGATATTGAGGCGAAAGAAAGAGAAGCTAGTGGAATTAACAACCTGAAGATTGATT
ACAATAAAAAAGATGGTTATTATTTCCATGTCACAAATTCCCAGCTTGAACACGTTCCCAGTCATTTTTTCCGCAAGGCA
ACTCTGAAAAATTCAGAGCGTTTTGGTACGGAAGAACTGGCTCGTATTGAAGGGGAGATGTTGGAAGCGCGTGAAAAATC
AGCTAATTTGGAATACGAGATTTTTATGCGCATTCGTGAGGAAGCTGGTAAATATATCAAACGCCTGCAATCCTTGGCGC
AAACTATGGCAACAGTTGATGTGCTGCAAAGCTTTGCAGCTGTAGCTGAAAAGCAACACTTTGTGAGACCAGAATTTATT
GAGCAGCGCTCTATCCAAATTGATAAAGGGCGGCATGCGGTCGTAGAAAAAGTTATGGGTGCACAAACCTATATTCCTAA
TAGCATTTCAATGGATGAGAATGTTAATGTTCAGCTAATTACAGGCCCAAATATGAGTGGGAAGTCAACTTATATGCGGC
AGTTAGCGATTGTTGTGATTATGGCTCAAATGGGCTCTTATGTTTCAGCTGAAAGCGCTCAATTGCCGATTTTTGATGCA
ATCTTTACTCGAATTGGTGCAGCTGATGACTTGGTTTCTGGACAATCAACCTTTATGATTGAAATGATGGAAGCGAACCA
TGCTATTTCTCAAGCAACAGAAAATTCACTCATTCTTTTTGATGAGTTAGGAAGAGGAACAGCCACCTATGATGGCATGG
CGCTTGCTCAAGCTATTATTGAGTATATTCACAATCGGACAGGAGCTAAGACACTTTTTGCGACTCACTATCACGAGTTG
ACAGAACTGTCAACTAGCTTGACACAACTAGAAAATGTCCATGTAGCAACCCTAGAAAAAGATGGTCAAGTAACATTTCT
TCATAAGATTGAGGTTGGACCTGCTGATAAATCTTATGGGATTCATGTAGCAAAAATTGCAGGTTTGCCAAATGATTTGT
TGACAAGAGCGGATCAAATATTGACACGATTAGAAAGCCAAGTAAATGAGAAGCCATCTTTTGGCATCTTTAATACATTA
CCTGCGGATGCTCGTGAAAAAAATCAAGTGGCTGAGCAGATGTCTTTATTTACAGAAACAACTGAATCACCTATTTTAGA
CGAGTTGCGCCAGTTGGACATTTATAATATGACCCCAATGGAAGTGATGTTGGCTGTGGCAGAGATAAAGAAGAAACTTT
AA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (255-546)

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-505)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	76.788	100	0.768
mutS	Pseudomonas stutzeri strain ATCC 17587	36.227	100	0.367