Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   PUW52_RS10215 Genome accession   NZ_CP118078
Coordinates   2000114..2002060 (-) Length   648 a.a.
NCBI ID   WP_024053225.1    Uniprot ID   A0A413KPH1
Organism   Streptococcus anginosus strain VSI16     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1995114..2007060
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PUW52_RS10190 (PUW52_10190) cinA 1995531..1996802 (-) 1272 WP_070242126.1 competence/damage-inducible protein A Machinery gene
  PUW52_RS10195 (PUW52_10195) - 1997512..1997822 (+) 311 Protein_1962 EamA family transporter -
  PUW52_RS10200 (PUW52_10200) - 1997925..1998503 (-) 579 WP_024053222.1 DNA-3-methyladenine glycosylase I -
  PUW52_RS10205 (PUW52_10205) ruvA 1998514..1999104 (-) 591 WP_024053223.1 Holliday junction branch migration protein RuvA Machinery gene
  PUW52_RS10210 (PUW52_10210) - 1999266..1999709 (+) 444 WP_024053224.1 helix-turn-helix transcriptional regulator -
  PUW52_RS10215 (PUW52_10215) hexB 2000114..2002060 (-) 1947 WP_024053225.1 DNA mismatch repair endonuclease MutL Machinery gene
  PUW52_RS10220 (PUW52_10220) - 2002314..2002754 (+) 441 WP_024053226.1 LytTR family DNA-binding domain-containing protein -
  PUW52_RS10225 (PUW52_10225) - 2002751..2003209 (+) 459 WP_024053227.1 DUF3021 domain-containing protein -
  PUW52_RS10230 (PUW52_10230) hexA 2003398..2005959 (-) 2562 WP_024053228.1 DNA mismatch repair protein MutS Machinery gene
  PUW52_RS10235 (PUW52_10235) argR 2006328..2006768 (-) 441 WP_003027809.1 arginine repressor -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73403.55 Da        Isoelectric Point: 5.3163

>NTDB_id=721047 PUW52_RS10215 WP_024053225.1 2000114..2002060(-) (hexB) [Streptococcus anginosus strain VSI16]
MSKIIELPENLANQIAAGEVIERPSSVVKELIENSIDAGATRIIVEIEEAGLRSIQVIDNGEGIEHEEVSLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSRLTIETATSSGAHGTLLIAQGGEVETLEPSSCPRGTKIKVEDLFFNTPARLKY
MKSQQAELSHIVDVINRLSLAHPEVAFTLVNDGKEMTRTAGTGNLRQAIAGIYGLTTAKKMIEISASNLDFEVSGYISLP
ELTRANRNYITIFINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIDIRIDPYLADVNVHPTKQEVRISKERELMTLISQ
AIAASLKEQDLIPDALENLAKSTINRAIKPEQTSLPLKENRLYYDKERNDFFVKPQVSEAQPSFEESARLDQQSADTDEL
NSKAASVKFAERQSPSYNQLDHPELDQASLERALDKLNREETSTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYREKIGDVDASQQQLLVPYIFEFPADDMLRLKQRMTLLEEVGVFLEEYGTNQFILREHPIWFKEEEIESGIYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLIFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=721047 PUW52_RS10215 WP_024053225.1 2000114..2002060(-) (hexB) [Streptococcus anginosus strain VSI16]
ATGTCAAAAATTATTGAACTACCAGAAAATCTTGCTAATCAGATTGCAGCAGGTGAGGTCATCGAGCGACCTAGCAGCGT
GGTCAAGGAGTTGATAGAGAATTCCATTGATGCTGGTGCTACTCGGATTATAGTTGAGATTGAAGAAGCGGGACTCAGGA
GCATTCAAGTCATTGATAATGGTGAAGGAATTGAGCATGAGGAGGTTTCCTTGGCTTTGCGGCGGCATGCTACTAGTAAA
ATCAAGAAACAAGCCGACCTTTTTCGAATTCGGACATTGGGCTTTCGGGGAGAGGCACTTCCATCCATTGCCTCTGTTTC
ACGTTTGACGATTGAAACTGCGACAAGTAGTGGTGCACATGGAACGCTTCTGATTGCGCAAGGTGGAGAAGTTGAGACTT
TAGAGCCAAGTAGCTGTCCTAGGGGCACCAAAATCAAAGTGGAAGACCTTTTTTTCAACACGCCTGCTCGCTTGAAATAT
ATGAAAAGTCAACAAGCGGAACTATCTCACATTGTAGATGTGATTAACCGTTTGAGCTTGGCTCATCCGGAGGTCGCTTT
CACTCTTGTTAATGACGGTAAAGAGATGACACGGACAGCAGGAACAGGAAATCTGCGTCAAGCAATTGCTGGCATTTATG
GACTGACAACAGCCAAAAAAATGATTGAAATTTCAGCTTCTAATCTGGATTTTGAAGTATCAGGCTATATTAGTCTACCA
GAGTTGACGCGTGCCAATCGTAACTACATCACCATTTTCATCAATGGTCGTTACATCAAGAATTTCCTGCTCAATCGAGC
TATTCTTGATGGTTACGGTAGTAAGCTCATGGTTGGGCGATTCCCGATTGCTGTGATTGATATTCGGATTGACCCATATC
TTGCTGATGTCAATGTTCACCCGACCAAGCAAGAAGTGCGGATTTCAAAGGAGCGAGAGCTCATGACCTTGATATCGCAA
GCTATTGCTGCAAGTTTGAAAGAGCAAGATTTGATTCCGGACGCATTAGAGAATTTAGCCAAATCAACCATTAACCGAGC
AATTAAGCCTGAGCAGACCAGCCTCCCTCTCAAAGAGAACCGACTTTATTACGATAAAGAAAGAAATGACTTCTTTGTGA
AACCACAAGTGTCAGAAGCTCAACCTTCTTTTGAGGAATCTGCCCGATTAGACCAACAATCTGCTGATACAGATGAACTC
AATTCAAAAGCTGCTTCTGTCAAATTTGCAGAAAGGCAATCTCCTTCTTACAATCAACTAGATCATCCAGAGCTGGATCA
GGCGAGCTTAGAGAGAGCTTTAGATAAGCTAAATAGAGAAGAAACTTCAACGTTTCCAGAATTGGAATATTTCGGGCAAA
TGCACGGCACCTACCTTTTTGCTCAAGGAAACGGTGGTCTTTATATTATTGACCAACATGCAGCTCAAGAGCGAGTAAAG
TACGAATATTATCGTGAAAAAATCGGAGATGTAGATGCTAGTCAGCAGCAGCTTCTGGTTCCCTATATCTTTGAATTTCC
AGCTGATGATATGTTGCGTCTGAAACAACGAATGACTCTTTTAGAAGAAGTCGGTGTTTTCCTTGAAGAATACGGAACTA
ATCAATTTATTCTTCGTGAACATCCCATTTGGTTTAAGGAAGAGGAAATCGAATCAGGTATTTATGAGATGTGCGATATG
CTGCTTCTAACCAAGGAAGTCTCTATCAAGAAATATCGCGCTGAGCTGGCTATTATGATGAGTTGCAAACGCTCTATTAA
AGCCAATCACAGTTTAGATGACTATTCAGCGCGTGATTTGATTTTTCAGTTATCACAATGCGACAATCCCTACAACTGCC
CTCACGGTCGTCCCGTTTTGGTCAACTTCACCAAATCTGATATGGAAAAAATGTTCCGTCGGATTCAGGAAAATCATACT
AGCCTGAGAGAATTGGGCAAGTATTAA

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A413KPH1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

77.35

100

0.775