Detailed information NTG0720939

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: PUW49_RS10520
• Genome accession: NZ_CP118054
• Coordinates: 2054821..2057382 (-)
• Length: 853 a.a.
• NCBI ID: WP_024053228.1
• Uniprot ID: A0ABS3GCR8
• Organism: Streptococcus anginosus strain VSI37
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 2049821..2062382

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PUW49_RS10495 (PUW49_10495)	ruvA	2049892..2050482 (-)	591	WP_003026647.1	Holliday junction branch migration protein RuvA	Machinery gene
PUW49_RS10500 (PUW49_10500)	-	2050644..2051087 (+)	444	WP_024053224.1	helix-turn-helix transcriptional regulator	-
PUW49_RS10505 (PUW49_10505)	mutL	2051536..2053483 (-)	1948	Protein_2033	DNA mismatch repair endonuclease MutL	-
PUW49_RS10510 (PUW49_10510)	-	2053737..2054177 (+)	441	WP_024053226.1	LytTR family DNA-binding domain-containing protein	-
PUW49_RS10515 (PUW49_10515)	-	2054174..2054632 (+)	459	WP_024053227.1	DUF3021 domain-containing protein	-
PUW49_RS10520 (PUW49_10520)	hexA	2054821..2057382 (-)	2562	WP_024053228.1	DNA mismatch repair protein MutS	Machinery gene
PUW49_RS10525 (PUW49_10525)	argR	2057751..2058191 (-)	441	WP_003027809.1	arginine repressor	-
PUW49_RS10530 (PUW49_10530)	argS	2058295..2059983 (+)	1689	WP_024053229.1	arginine--tRNA ligase	-
PUW49_RS10535 (PUW49_10535)	nrdI	2060038..2060493 (-)	456	WP_024053230.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
PUW49_RS10540 (PUW49_10540)	-	2060569..2061078 (-)	510	WP_024053231.1	hypothetical protein	-

Sequence

Protein

• Length: 853 a.a.
• Molecular weight: 96064.79 Da
• Isoelectric Point: 5.0391

>NTDB_id=720939 PUW49_RS10520 WP_024053228.1 2054821..2057382(-) (hexA) [Streptococcus anginosus strain VSI37]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDATNAAQILEIALTSRNKNSENPIPMAGVPYHSVQQYIDVLI
EAGYKVAIAEQMEDPKKAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVALDKLSGIYGLAYMDVGTGEFQVTSLSDFNI
VCGEIRNLRAREVVLGYELSEMERQVLETQMNLLLSQVETTFDDVQLLGKDLSPLERQVAGKLLQYVHKTQLRELSHLKQ
VHHYEIKDFLQMDYSTMASLDLIENARTGKKHGSLYWLMDETKTAMGTRLLRAWIQRPLIDKERIVKRQDVVQVFLDHFF
ERSDLSDSLKGVYDIERLASRVSFGKTNPKDLLQLAATLSHVPQIKGILKGIDSPVLEDLIAKLDEIPELASLIQSAISP
DAPNVITEGNIIKTGFDETLDKYRVVIRDGTSWIADIEAKEREASGINNLKIDYNKKDGYYFHVTNSQLEHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEAGKYIKRLQSLAQTMATVDVLQSFAAVAEKQHFVRPEFI
EQRSIQIDKGRHAVVEKVMGAQTYIPNSISMDENVNVQLITGPNMSGKSTYMRQLAIVVIMAQMGSYVSAESAQLPIFDA
IFTRIGAADDLVSGQSTFMIEMMEANHAISQATENSLILFDELGRGTATYDGMALAQAIIEYIHNRTGAKTLFATHYHEL
TELSTSLTQLENVHVATLEKDGQVTFLHKIEVGPADKSYGIHVAKIAGLPNDLLTRADQILTRLESQVNEKPSFGIFNTL
PADAREKNQVAEQMSLFTETTESPILDELRQLDIYNMTPMEVMLAVAEIKKKL

Nucleotide

• Length: 2562 bp

>NTDB_id=720939 PUW49_RS10520 WP_024053228.1 2054821..2057382(-) (hexA) [Streptococcus anginosus strain VSI37]
ATGACAAAAGAAAAACTATCTCCAGGAATGCAACAGTATTTAGATATAAAAAAAGATTATCCAGATGCTTTTTTGTTGTT
TCGCATGGGAGATTTTTATGAATTATTCTATGATGATGCGACCAATGCGGCACAGATTTTAGAGATTGCTCTGACTAGTC
GCAATAAAAACTCGGAAAATCCAATCCCAATGGCAGGAGTTCCTTACCATTCAGTGCAGCAATACATTGATGTTTTAATT
GAAGCAGGCTATAAAGTTGCGATTGCAGAGCAAATGGAAGATCCTAAAAAAGCGGTTGGAGTAGTCAAACGCGAAGTAGT
ACAGGTGATTACGCCGGGGACAGTAGTTGATTCTTCAAAACCAGACAGTCAGAATAACTTTTTAGTGGCTTTGGATAAGC
TGTCAGGTATATATGGACTGGCTTATATGGATGTGGGAACGGGTGAATTTCAGGTCACAAGTCTTAGTGACTTTAACATA
GTCTGTGGAGAAATCCGAAACCTGCGAGCGCGTGAAGTGGTCTTAGGGTATGAATTGTCTGAAATGGAGCGCCAAGTATT
GGAGACTCAAATGAATCTCCTTTTATCGCAAGTAGAAACTACATTTGATGATGTTCAGCTACTAGGAAAGGACTTGTCGC
CGCTAGAGCGCCAAGTAGCTGGAAAGTTATTACAGTATGTTCATAAAACGCAGCTACGTGAGCTTAGTCATTTGAAACAA
GTTCATCATTATGAAATCAAAGATTTCTTGCAGATGGACTACTCAACTATGGCAAGTCTGGATTTAATAGAGAATGCTCG
AACAGGAAAGAAGCACGGGAGCCTTTATTGGCTGATGGATGAGACTAAGACAGCTATGGGAACACGATTGTTGAGAGCGT
GGATTCAACGTCCGTTGATTGATAAAGAGCGGATCGTCAAGCGGCAGGATGTAGTGCAAGTCTTTTTAGATCATTTCTTT
GAGCGCAGTGACTTATCAGACAGTCTCAAAGGAGTGTATGATATTGAGCGTTTAGCCAGTCGGGTTTCGTTTGGCAAGAC
CAATCCGAAAGATCTATTACAACTTGCTGCGACATTGAGTCATGTGCCACAAATTAAGGGAATTTTAAAAGGAATTGATA
GCCCAGTTTTGGAAGATTTGATTGCAAAATTGGATGAAATTCCTGAACTGGCGTCCTTAATTCAGTCAGCAATTTCGCCG
GATGCTCCAAATGTCATTACAGAGGGTAATATTATTAAAACAGGTTTTGATGAAACCTTGGATAAATATCGAGTGGTTAT
ACGAGATGGAACGAGCTGGATTGCAGATATTGAGGCGAAAGAAAGAGAAGCTAGTGGAATTAACAACCTGAAGATTGATT
ACAATAAAAAAGATGGTTATTATTTCCATGTCACAAATTCCCAGCTTGAACACGTTCCCAGTCATTTTTTCCGCAAGGCA
ACTCTGAAAAATTCAGAGCGTTTTGGTACGGAAGAACTGGCTCGTATTGAAGGGGAGATGTTGGAAGCGCGTGAAAAATC
AGCTAATTTGGAATACGAGATTTTTATGCGCATTCGTGAGGAAGCTGGTAAATATATCAAACGCCTGCAATCCTTGGCGC
AAACTATGGCAACAGTTGATGTGCTGCAAAGCTTTGCAGCTGTAGCTGAAAAGCAACACTTTGTGAGACCAGAATTTATT
GAGCAGCGCTCTATCCAAATTGATAAAGGGCGGCATGCGGTCGTAGAAAAAGTTATGGGTGCACAAACCTATATTCCTAA
TAGCATTTCAATGGATGAGAATGTTAATGTTCAGCTAATTACAGGCCCAAATATGAGTGGGAAGTCAACTTATATGCGGC
AGTTAGCGATTGTTGTGATTATGGCTCAAATGGGCTCTTATGTTTCAGCTGAAAGCGCTCAATTGCCGATTTTTGATGCA
ATCTTTACTCGAATTGGTGCAGCTGATGACTTGGTTTCTGGACAATCAACCTTTATGATTGAAATGATGGAAGCGAACCA
TGCTATTTCTCAAGCAACAGAAAATTCACTCATTCTTTTTGATGAGTTAGGAAGAGGAACAGCCACCTATGATGGCATGG
CGCTTGCTCAAGCTATTATTGAGTATATTCACAATCGGACAGGAGCTAAGACACTTTTTGCGACTCACTATCACGAGTTG
ACAGAACTGTCAACTAGCTTGACACAACTAGAAAATGTCCATGTAGCAACCCTAGAAAAAGATGGTCAAGTAACATTTCT
TCATAAGATTGAGGTTGGACCTGCTGATAAATCTTATGGGATTCATGTAGCAAAAATTGCAGGTTTGCCAAATGATTTGT
TGACAAGAGCGGATCAAATATTGACACGATTAGAAAGCCAAGTAAATGAGAAGCCATCTTTTGGCATCTTTAATACATTA
CCTGCGGATGCTCGTGAAAAAAATCAAGTGGCTGAGCAGATGTCTTTATTTACAGAAACAACTGAATCACCTATTTTAGA
CGAGTTGCGCCAGTTGGACATTTATAATATGACCCCAATGGAAGTGATGTTGGCTGTGGCAGAGATAAAGAAGAAACTTT
AA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (255-546)

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-505)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	76.788	100	0.768
mutS	Pseudomonas stutzeri strain ATCC 17587	36.227	100	0.367