Detailed information NTG0071816

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EL277_RS10070
• Genome accession: NZ_AP018936
• Coordinates: 1894252..1895289 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain NU83127
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1889252..1900289

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL277_RS10045 (SPNU_1900)	-	1890053..1891384 (-)	1332	WP_000390039.1	hemolysin family protein	-
EL277_RS10050 (SPNU_1901)	endA	1891613..1892437 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
EL277_RS10055 (SPNU_1902)	-	1892476..1892664 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
EL277_RS10060 (SPNU_1903)	murA	1892657..1893940 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EL277_RS10065 (SPNU_1904)	-	1893964..1894194 (-)	231	WP_000250384.1	DUF1146 family protein	-
EL277_RS10070 (SPNU_1905)	sepM	1894252..1895289 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EL277_RS10075 (SPNU_1906)	coaD	1895273..1895761 (-)	489	WP_001280753.1	pantetheine-phosphate adenylyltransferase	-
EL277_RS10080 (SPNU_1907)	rsmD	1895751..1896290 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EL277_RS10085 (SPNU_1908)	asnA	1896355..1897347 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EL277_RS10095 (SPNU_1909)	-	1897459..1898142 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EL277_RS10100 (SPNU_1910)	-	1898198..1898938 (-)	741	WP_126443184.1	TrmH family RNA methyltransferase	-
EL277_RS10105 (SPNU_1911)	-	1898972..1899250 (+)	279	WP_001174612.1	acylphosphatase	-
EL277_RS10110 (SPNU_1912)	yidC	1899328..1900254 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=71816 EL277_RS10070 WP_000727277.1 1894252..1895289(-) (sepM) [Streptococcus pneumoniae strain NU83127]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=71816 EL277_RS10070 WP_000727277.1 1894252..1895289(-) (sepM) [Streptococcus pneumoniae strain NU83127]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591