Detailed information NTG0715009

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NQZ90_RS04030
• Genome accession: NZ_CP102148
• Coordinates: 819360..820031 (+)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain DNC15
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 814360..825031

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NQZ90_RS04000 (NQZ90_04000)	pstC	814543..815460 (+)	918	WP_044678150.1	phosphate ABC transporter permease subunit PstC	-
NQZ90_RS04005 (NQZ90_04005)	pstA	815450..816337 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
NQZ90_RS04010 (NQZ90_04010)	pstB	816362..817165 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ90_RS04015 (NQZ90_04015)	pstB	817177..817935 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ90_RS04020 (NQZ90_04020)	phoU	817964..818620 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
NQZ90_RS04025 (NQZ90_04025)	-	818786..819166 (+)	381	WP_024389002.1	hypothetical protein	-
NQZ90_RS04030 (NQZ90_04030)	ciaR	819360..820031 (+)	672	WP_024385291.1	response regulator transcription factor	Regulator
NQZ90_RS04035 (NQZ90_04035)	ciaH	820024..821403 (+)	1380	WP_024385779.1	cell wall metabolism sensor histidine kinase WalK	Regulator
NQZ90_RS04040 (NQZ90_04040)	-	821503..822732 (+)	1230	WP_024385778.1	transglutaminase domain-containing protein	-
NQZ90_RS04045 (NQZ90_04045)	rpsT	822984..823232 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
NQZ90_RS04050 (NQZ90_04050)	coaA	823291..824211 (-)	921	WP_024389003.1	type I pantothenate kinase	-
NQZ90_RS04055 (NQZ90_04055)	-	824320..824910 (+)	591	WP_024389004.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=715009 NQZ90_RS04030 WP_024385291.1 819360..820031(+) (ciaR) [Streptococcus suis strain DNC15]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=715009 NQZ90_RS04030 WP_024385291.1 819360..820031(+) (ciaR) [Streptococcus suis strain DNC15]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368