Detailed information NTG0714251

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NF392_RS04550
• Genome accession: NZ_CP102089
• Coordinates: 976291..977337 (+)
• Length: 348 a.a.
• NCBI ID: WP_002435929.1
• Uniprot ID: A0A0S4MEI3
• Organism: Staphylococcus capitis subsp. capitis strain H17
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 971291..982337

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NF392_RS04520	-	971555..972280 (+)	726	WP_002469718.1	type 1 glutamine amidotransferase	-
NF392_RS04525	isaB	972509..973051 (+)	543	WP_145350322.1	immunodominant staphylococcal antigen IsaB family protein	-
NF392_RS04530	-	973129..974118 (-)	990	WP_002435886.1	FUSC family protein	-
NF392_RS04535	map	974292..975047 (+)	756	WP_002435911.1	type I methionyl aminopeptidase	-
NF392_RS04540	-	975192..975578 (+)	387	WP_002453601.1	hypothetical protein	-
NF392_RS04545	liaF	975593..976294 (+)	702	WP_002435891.1	cell wall-active antibiotics response protein LiaF	-
NF392_RS04550	vraS	976291..977337 (+)	1047	WP_002435929.1	sensor histidine kinase	Regulator
NF392_RS04555	vraR	977327..977956 (+)	630	WP_002469716.1	two-component system response regulator VraR	Regulator
NF392_RS04560	-	978021..979274 (-)	1254	WP_002435884.1	YihY/virulence factor BrkB family protein	-
NF392_RS04565	-	979611..979895 (-)	285	WP_002435890.1	hypothetical protein	-
NF392_RS04570	-	979902..980366 (-)	465	WP_002435947.1	low molecular weight protein-tyrosine-phosphatase	-
NF392_RS04575	-	980507..980713 (+)	207	WP_002435959.1	DUF1128 domain-containing protein	-
NF392_RS04580	-	980727..981968 (+)	1242	WP_023350031.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40136.57 Da
• Isoelectric Point: 6.0600

>NTDB_id=714251 NF392_RS04550 WP_002435929.1 976291..977337(+) (vraS) [Staphylococcus capitis subsp. capitis strain H17]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNILIILLCIIVGSVLAYKINQQNDWLKS
QIERSIEGETVGINDQNLELYSETLEIYHTLVPLNQELHRLRMKTQNMTNENYNMNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGSKVTVELFNKEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDESNGD

Nucleotide

• Length: 1047 bp

>NTDB_id=714251 NF392_RS04550 WP_002435929.1 976291..977337(+) (vraS) [Staphylococcus capitis subsp. capitis strain H17]
ATGAATCACTACTTGAGAGCAATTGGTTCAATGCTAATACTTGTATATAGCATGCTAACTGCTTTTTTATTCATTGATAA
GGTGTTCGTCAATATTATTTATTTTCAAGGGATGTTTTACACCCAAATTTTTGGAATACCAGTATTTTTATTCCTAAATA
TATTAATCATCTTACTATGTATTATCGTTGGCTCTGTGTTAGCGTATAAAATCAATCAACAAAATGATTGGCTTAAGTCA
CAAATTGAAAGGTCTATTGAAGGTGAAACAGTAGGCATAAATGATCAAAACCTAGAGTTATACAGTGAAACGTTAGAAAT
TTACCATACTTTAGTTCCTTTAAATCAAGAATTACACCGATTGAGAATGAAAACGCAGAATATGACCAATGAAAATTATA
ATATGAATGATGTAAAAGTGAAGAAAATTATTGAAGACGAACGTCAACGTTTAGCAAGAGAACTACATGACTCAGTTAGT
CAGCAACTATTTGCAGCAAGTATGATGTTGTCAGCGATTAAAGAGTCAAAATTAGAACCACCTTTAGACCAACAAATACC
TGTACTAGAGAAGATGGTTCAAGACTCTCAGCTCGAAATGAGAGCATTATTATTACATCTAAGACCTATTGGTTTGAAAG
ACAAATCATTAGGAGAGGGTATTAAAGATTTAGTCATTGATCTTCAAAAGAAAGTCCCTATGAAAGTTGTTCATGAAATT
CAAGATTTCAAAGTACCAAAAGGGATAGAAGATCATTTGTTTAGAATCACCCAAGAGGCTATTTCTAATACATTACGACA
CTCTAATGGTTCTAAGGTAACAGTTGAATTATTTAATAAAGAAGATTATTTACTACTTAGAATTCAAGATAATGGTAAAG
GTTTTAATGTAGATGAAAAATTTGAACAGAGTTATGGATTAAAAAATATGAGAGAACGTGCTTTAGAGATTGGTGCCACA
TTCCATATCGTATCGTTACCGGATTCAGGTACGAGAATAGAAGTTAAAGCACCATTGAATAAGGAGGATGAATCAAATGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A0S4MEI3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.586	98.563	0.922