Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   NQD70_RS06975 Genome accession   NZ_CP101991
Coordinates   1341786..1343012 (-) Length   408 a.a.
NCBI ID   WP_000918415.1    Uniprot ID   A0A0H1T4M5
Organism   Streptococcus agalactiae strain BCJB4361     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1304474..1344643 1341786..1343012 within 0


Gene organization within MGE regions


Location: 1304474..1344643
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NQD70_RS06815 (NQD70_06810) - 1304474..1305076 (-) 603 WP_000670189.1 nitroreductase family protein -
  NQD70_RS06820 (NQD70_06815) - 1305246..1307027 (+) 1782 WP_000942623.1 glycerophosphodiester phosphodiesterase -
  NQD70_RS06830 (NQD70_06825) uvrC 1308504..1310285 (-) 1782 WP_001003955.1 excinuclease ABC subunit UvrC -
  NQD70_RS06835 (NQD70_06830) - 1310444..1311211 (+) 768 WP_000567585.1 epoxyqueuosine reductase QueH -
  NQD70_RS06840 (NQD70_06835) - 1311270..1312610 (-) 1341 WP_000285045.1 MATE family efflux transporter -
  NQD70_RS06845 (NQD70_06840) - 1312710..1313126 (-) 417 WP_000245058.1 VOC family protein -
  NQD70_RS06850 (NQD70_06845) - 1313130..1313627 (-) 498 WP_000582587.1 hypothetical protein -
  NQD70_RS06855 (NQD70_06850) - 1313849..1314445 (+) 597 WP_000162275.1 Ltp family lipoprotein -
  NQD70_RS06860 (NQD70_06855) - 1314634..1315739 (+) 1106 WP_088197863.1 IS3-like element ISSag2 family transposase -
  NQD70_RS06865 (NQD70_06860) - 1315960..1317095 (+) 1136 Protein_1275 IS3 family transposase -
  NQD70_RS06870 (NQD70_06865) - 1317135..1317374 (+) 240 Protein_1276 integrase core domain-containing protein -
  NQD70_RS06875 (NQD70_06870) - 1317573..1320041 (-) 2469 WP_000754588.1 pneumococcal-type histidine triad protein -
  NQD70_RS06880 (NQD70_06875) lmb 1320054..1320974 (-) 921 WP_000755138.1 metal ABC transporter substrate-binding lipoprotein/laminin-binding adhesin Lmb -
  NQD70_RS06885 (NQD70_06880) ltrA 1321208..1322485 (-) 1278 WP_001292562.1 group II intron reverse transcriptase/maturase -
  NQD70_RS06890 (NQD70_06885) scpA/B 1323067..1326519 (-) 3453 WP_001227837.1 C5a peptidase ScpA/B -
  NQD70_RS06895 (NQD70_06890) - 1327173..1328507 (-) 1335 WP_000453221.1 ISLre2 family transposase -
  NQD70_RS06900 (NQD70_06895) - 1328615..1329163 (-) 549 WP_000584204.1 hypothetical protein -
  NQD70_RS06905 (NQD70_06900) - 1329260..1329490 (-) 231 WP_000863581.1 hypothetical protein -
  NQD70_RS06910 (NQD70_06905) - 1329559..1329918 (-) 360 Protein_1284 ParA family protein -
  NQD70_RS06915 (NQD70_06910) - 1329954..1330477 (+) 524 Protein_1285 transposase -
  NQD70_RS06920 (NQD70_06915) - 1330548..1331653 (+) 1106 WP_088197863.1 IS3-like element ISSag2 family transposase -
  NQD70_RS06925 (NQD70_06920) - 1331778..1333013 (+) 1236 WP_065735653.1 AbiH family protein -
  NQD70_RS06930 (NQD70_06925) rplL 1333148..1333513 (-) 366 WP_001196973.1 50S ribosomal protein L7/L12 -
  NQD70_RS06935 (NQD70_06930) rplJ 1333577..1334077 (-) 501 WP_001287287.1 50S ribosomal protein L10 -
  NQD70_RS06940 (NQD70_06935) - 1334510..1336618 (+) 2109 WP_000002813.1 AAA family ATPase -
  NQD70_RS06945 (NQD70_06940) mmuM 1336711..1337655 (-) 945 WP_000532340.1 homocysteine S-methyltransferase -
  NQD70_RS06950 (NQD70_06945) - 1337660..1339036 (-) 1377 WP_000427485.1 amino acid permease -
  NQD70_RS06955 (NQD70_06950) - 1339166..1339816 (-) 651 WP_000120093.1 HXXEE domain-containing protein -
  NQD70_RS06960 (NQD70_06955) - 1339974..1340477 (-) 504 WP_000645480.1 HXXEE domain-containing protein -
  NQD70_RS06965 (NQD70_06960) - 1340569..1341117 (+) 549 WP_000140662.1 TetR/AcrR family transcriptional regulator -
  NQD70_RS06970 (NQD70_06965) yihA 1341179..1341775 (-) 597 WP_000796925.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  NQD70_RS06975 (NQD70_06970) clpX 1341786..1343012 (-) 1227 WP_000918415.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  NQD70_RS06980 (NQD70_06975) - 1343230..1343724 (-) 495 WP_000166043.1 dihydrofolate reductase -
  NQD70_RS06985 (NQD70_06980) - 1343804..1344643 (-) 840 WP_000158595.1 thymidylate synthase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 44836.25 Da        Isoelectric Point: 4.4424

>NTDB_id=713762 NQD70_RS06975 WP_000918415.1 1341786..1343012(-) (clpX) [Streptococcus agalactiae strain BCJB4361]
MAGNRNNDMNVYCSFCGKSQDEVKKIIAGNGVFICNECVALSQEIIKEELAEEVLADLAEVPKPKELLEILNQYVVGQDR
AKRALAVAVYNHYKRVSYTESSDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENIL
LKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQINTKN
ILFIVGGAFDGIEDLVKQRLGEKVIGFGQTSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALELLTAEDLVRIL
TEPRNALVKQYQTLLSYDGVELEFDQDALLAIADKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEGT
DKPVLETA

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=713762 NQD70_RS06975 WP_000918415.1 1341786..1343012(-) (clpX) [Streptococcus agalactiae strain BCJB4361]
ATGGCTGGGAATCGTAATAACGATATGAATGTCTATTGTTCATTTTGTGGCAAAAGCCAAGATGAAGTAAAAAAAATTAT
TGCAGGTAATGGTGTTTTCATTTGTAATGAATGTGTGGCCTTATCACAAGAAATTATTAAGGAAGAATTAGCTGAGGAAG
TACTGGCTGATTTAGCAGAAGTACCAAAACCTAAGGAACTATTAGAAATATTAAATCAATATGTTGTAGGGCAAGATCGT
GCTAAACGTGCTTTAGCAGTTGCTGTCTACAATCATTACAAGCGTGTTAGTTATACCGAGAGTAGTGACGATGATGTAGA
TTTGCAAAAATCCAACATTTTGATGATTGGTCCAACTGGCTCAGGAAAAACCTTCTTAGCACAAACACTGGCTAAAAGCC
TTAATGTACCGTTTGCTATTGCAGATGCGACTTCATTGACCGAAGCAGGATACGTTGGAGAAGATGTTGAGAATATTCTT
CTTAAATTGATTCAAGCTGCTGATTATAATGTCGAACGTGCTGAGCGTGGTATTATCTACGTTGATGAAATAGATAAAAT
TGCTAAGAAAGGCGAAAATGTTTCTATCACACGTGATGTGTCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTATTG
AGGGTACGGTAGCAAGTGTTCCCCCACAGGGTGGGCGTAAACATCCTAACCAAGAAATGATTCAAATTAATACCAAGAAC
ATCCTTTTTATTGTCGGTGGTGCTTTTGATGGTATTGAAGACCTTGTGAAGCAACGTTTAGGCGAAAAAGTTATTGGTTT
TGGACAGACAAGCCGTAAAATTGATGACAACGCTTCTTATATGCAAGAGATAATTTCTGAGGATATTCAAAAGTTTGGAC
TGATTCCAGAGTTTATTGGCCGTTTACCAGTAGTTGCAGCGTTAGAACTTCTTACTGCAGAAGATCTGGTTCGTATTCTG
ACAGAACCACGCAATGCTTTGGTTAAACAATACCAAACCTTATTATCTTATGATGGTGTAGAATTGGAATTTGACCAGGA
TGCTCTATTGGCTATCGCTGATAAGGCTATCGAGCGCAAGACTGGTGCACGTGGTTTACGTTCTATTATTGAAGAAACGA
TGCTTGATATCATGTTTGAAATTCCAAGCCAAGAAGATGTAACAAAAGTTCGTATCACAAAGGCTGCTGTTGAGGGTACT
GACAAGCCTGTTTTAGAGACGGCTTAG

Domains

Predicted by InterproScan.

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

AAA domain (Cdc48 subfamily) (AAA_2)

(109-304)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(311-390)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H1T4M5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

90.465

100

0.907
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.25

98.039

0.571