Detailed information NTG0712307

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: NOV99_RS03290
• Genome accession: NZ_CP101844
• Coordinates: 666757..667446 (+)
• Length: 229 a.a.
• NCBI ID: WP_002942700.1
• Uniprot ID: A0A126UNE5
• Organism: Streptococcus suis strain 2018WUSS151
• Function: repress comR expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	667556..668845	666757..667446	flank	110

Gene organization within MGE regions

Location: 666757..668845

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NOV99_RS03290 (NOV99_03290)	covR	666757..667446 (+)	690	WP_002942700.1	DNA-binding response regulator	Regulator
NOV99_RS03295 (NOV99_03295)	-	667556..668845 (+)	1290	WP_002937360.1	IS4-like element ISSsu2 family transposase	-

Sequence

Protein

• Length: 229 a.a.
• Molecular weight: 26225.11 Da
• Isoelectric Point: 5.3968

>NTDB_id=712307 NOV99_RS03290 WP_002942700.1 666757..667446(+) (covR) [Streptococcus suis strain 2018WUSS151]
MAKKILIAGKERNLSHFVSMELQKKDYLVDYASTGKEAMSLAHETDFDLILMSFQLSDMSSKELAAELLAIKPATVMIVV
VEPTEVSQYGEEVLSYAVSYVVKPFVISDLVEQISAIFRGRDFIDNNCKQVHMHAAYRDLKVDFQNRTVTRGDELINLTR
REYDLLATLMNSPEPVSREQLLERVWKYEAASETNVVDVYIRYLRGKLDLPHQDSYIKTVRGVGYAMRD

Nucleotide

• Length: 690 bp

>NTDB_id=712307 NOV99_RS03290 WP_002942700.1 666757..667446(+) (covR) [Streptococcus suis strain 2018WUSS151]
ATGGCTAAGAAAATTTTGATTGCTGGTAAAGAACGCAATCTCTCGCATTTTGTTTCCATGGAATTGCAGAAAAAAGACTA
TCTTGTTGATTATGCATCGACAGGGAAAGAGGCTATGTCCTTGGCACATGAAACGGATTTTGACTTGATTCTGATGAGTT
TTCAGCTTTCAGACATGTCCAGCAAGGAATTGGCTGCAGAACTATTAGCGATAAAACCAGCCACGGTCATGATTGTGGTA
GTTGAGCCGACAGAAGTTAGTCAATATGGGGAAGAAGTCCTCTCTTATGCTGTTTCCTACGTAGTGAAGCCCTTTGTCAT
CAGTGATTTAGTGGAGCAAATCTCTGCGATTTTTCGTGGTCGTGATTTTATTGACAATAACTGTAAACAGGTTCACATGC
ATGCGGCCTATCGTGATTTGAAGGTTGATTTTCAAAATCGAACAGTGACTCGAGGTGATGAATTGATTAATTTGACCCGC
CGAGAGTATGATCTGTTGGCGACCTTAATGAATAGCCCAGAGCCTGTTAGTCGAGAACAACTTCTTGAGCGTGTTTGGAA
ATATGAAGCGGCTTCTGAGACCAATGTCGTCGATGTATATATTCGCTATCTACGTGGTAAACTGGATTTGCCACATCAAG
ATTCATATATAAAAACAGTTCGTGGTGTCGGATATGCCATGCGCGATTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-227)

• Response regulator receiver domain (Response_reg) (5-114)

3D structure

• AlphaFold DB: A0A126UNE5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Streptococcus salivarius strain HSISS4	47.619	100	0.48
covR	Lactococcus lactis subsp. lactis strain DGCC12653	41.949	100	0.432