Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   PIC88_RS13545 Genome accession   NZ_CP116188
Coordinates   2748898..2749554 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain DETEC-E223     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2743898..2754554
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PIC88_RS13515 (PIC88_13510) yecA 2745150..2745815 (-) 666 WP_000847902.1 UPF0149 family protein YecA -
  PIC88_RS13535 (PIC88_13530) pgsA 2746464..2747012 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  PIC88_RS13540 (PIC88_13535) uvrC 2747069..2748901 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  PIC88_RS13545 (PIC88_13540) letA 2748898..2749554 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  PIC88_RS24870 - 2749696..2749812 (+) 117 WP_001302039.1 hypothetical protein -
  PIC88_RS13550 (PIC88_13545) yecU 2749850..2750026 (+) 177 WP_000590344.1 protein YecU -
  PIC88_RS13555 (PIC88_13550) yecF 2750013..2750237 (+) 225 WP_000106474.1 DUF2594 family protein YecF -
  PIC88_RS13560 (PIC88_13555) sdiA 2750305..2751027 (-) 723 WP_001154260.1 transcriptional regulator SdiA -
  PIC88_RS13565 (PIC88_13560) tcyN 2751257..2752009 (-) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  PIC88_RS13570 (PIC88_13565) tcyL 2752006..2752674 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  PIC88_RS13575 (PIC88_13570) dcyD 2752689..2753675 (-) 987 WP_001128215.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=708904 PIC88_RS13545 WP_000611328.1 2748898..2749554(-) (letA) [Escherichia coli strain DETEC-E223]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=708904 PIC88_RS13545 WP_000611328.1 2748898..2749554(-) (letA) [Escherichia coli strain DETEC-E223]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482