Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   H7675_RS03895 Genome accession   NZ_AP023389
Coordinates   741667..742329 (+) Length   220 a.a.
NCBI ID   WP_002995626.1    Uniprot ID   A0A0H2UV22
Organism   Streptococcus pyogenes strain KUN-0012590     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 736667..747329
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7675_RS03875 (KUN2590_07060) - 737541..739541 (+) 2001 WP_184004926.1 potassium transporter Kup -
  H7675_RS03880 (KUN2590_07070) - 739565..739843 (-) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  H7675_RS03885 (KUN2590_07080) - 739833..740609 (-) 777 WP_002994360.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  H7675_RS03890 (KUN2590_07090) - 740727..741467 (+) 741 WP_012560804.1 lysophospholipid acyltransferase family protein -
  H7675_RS03895 (KUN2590_07100) comEA/celA/cilE 741667..742329 (+) 663 WP_002995626.1 ComEA family DNA-binding protein Machinery gene
  H7675_RS03900 (KUN2590_07110) comEC/celB 742310..744553 (+) 2244 WP_030126964.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  H7675_RS03905 (KUN2590_07120) holA 744624..745664 (+) 1041 WP_011054659.1 DNA polymerase III subunit delta -
  H7675_RS03910 (KUN2590_07130) sodA 745761..746366 (+) 606 WP_184004928.1 superoxide dismutase SodA -
  H7675_RS09525 (KUN2590_07140) - 746533..746766 (+) 234 WP_002983979.1 hypothetical protein -

Sequence

Protein


Download         Length: 220 a.a.        Molecular weight: 24623.45 Da        Isoelectric Point: 6.7451

>NTDB_id=70462 H7675_RS03895 WP_002995626.1 741667..742329(+) (comEA/celA/cilE) [Streptococcus pyogenes strain KUN-0012590]
MLDELLIKGKSFLRERYFLPYLISLLLGLFLILSFSFLFWGNRQSKAAVPALREISPVKQQVSEEKKEIQEDNSILVDLK
GAVQKEGVYKLTASSRVRDVIELAGGLTSEADKHAINFAEKLTDEQVVYVPKQGEEISVLPRSLVSGKKETASKDQSKVH
INKASLEELQHIPGIGAKRAQDIIDMRDKLGGFKALEDLRQVSGIGEKTLEKLKDDIFLD

Nucleotide


Download         Length: 663 bp        

>NTDB_id=70462 H7675_RS03895 WP_002995626.1 741667..742329(+) (comEA/celA/cilE) [Streptococcus pyogenes strain KUN-0012590]
ATGTTAGACGAATTATTAATTAAAGGAAAATCGTTTTTGAGAGAGCGGTATTTTCTGCCATACCTAATTAGTCTTTTATT
AGGACTTTTTCTAATACTAAGCTTCAGTTTTTTGTTCTGGGGAAATAGGCAGAGCAAGGCAGCCGTTCCTGCTTTGAGAG
AAATATCGCCTGTGAAACAGCAGGTTAGTGAAGAAAAAAAGGAAATTCAAGAAGATAACAGTATTTTAGTGGATTTAAAA
GGCGCCGTACAAAAAGAGGGAGTTTATAAGCTAACTGCTAGCAGTCGTGTGCGAGATGTCATTGAACTAGCTGGAGGCCT
AACTTCAGAAGCTGATAAACATGCTATTAATTTTGCAGAAAAACTAACTGATGAGCAAGTTGTTTATGTACCTAAACAAG
GAGAAGAGATTTCTGTGCTACCAAGGTCATTAGTTTCTGGTAAAAAAGAAACTGCCAGCAAGGATCAGTCAAAGGTTCAT
ATTAATAAGGCCAGCTTAGAAGAACTACAACATATCCCAGGTATTGGTGCTAAAAGAGCTCAGGATATTATTGATATGAG
AGATAAGTTAGGTGGTTTTAAAGCGTTAGAAGATCTCCGTCAGGTTTCGGGGATTGGCGAAAAAACGCTCGAGAAATTAA
AAGATGACATTTTCTTGGACTAA

Domains

Predicted by InterProScan.

SLBB domain (SLBB)

(77-130)

Helix-hairpin-helix motif (HHH_3)

(156-217)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UV22

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

42.995

94.091

0.405

Multiple sequence alignment