Detailed information NTG0069986

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: SA27298_RS06995
• Genome accession: NZ_AP018548
• Coordinates: 1433828..1434517 (-)
• Length: 229 a.a.
• NCBI ID: WP_018543712.1
• Uniprot ID: A0A3E5D5Y8
• Organism: Streptococcus anginosus strain CCUG 27928
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 1428828..1439517

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SA27298_RS06955 (SA27298_1421)	-	1429188..1429505 (-)	318	WP_003030405.1	hypothetical protein	-
SA27298_RS06960 (SA27298_1422)	-	1429815..1430081 (-)	267	WP_003030391.1	helix-turn-helix transcriptional regulator	-
SA27298_RS06965 (SA27298_1423)	-	1430074..1430364 (-)	291	WP_018543573.1	hypothetical protein	-
SA27298_RS06970 (SA27298_1424)	-	1430354..1431430 (-)	1077	WP_003030403.1	replication initiator protein A	-
SA27298_RS06975 (SA27298_1425)	-	1431431..1431616 (-)	186	WP_003030351.1	hypothetical protein	-
SA27298_RS06980 (SA27298_1426)	-	1431655..1432332 (-)	678	WP_003030358.1	DUF2786 domain-containing protein	-
SA27298_RS06985 (SA27298_1427)	-	1432334..1432585 (-)	252	WP_018543574.1	hypothetical protein	-
SA27298_RS06990 (SA27298_1428)	-	1433234..1433605 (-)	372	WP_003030375.1	hypothetical protein	-
SA27298_RS06995 (SA27298_1429)	covR	1433828..1434517 (-)	690	WP_018543712.1	response regulator transcription factor	Regulator
SA27298_RS07000 (SA27298_1430)	gndA	1434526..1435950 (-)	1425	WP_003030963.1	NADP-dependent phosphogluconate dehydrogenase	-
SA27298_RS07005 (SA27298_1431)	-	1436249..1436872 (-)	624	WP_003023578.1	DNA alkylation repair protein	-
SA27298_RS07010 (SA27298_1432)	-	1436923..1437459 (-)	537	WP_018543713.1	DUF177 domain-containing protein	-
SA27298_RS07015 (SA27298_1433)	-	1437569..1438426 (+)	858	WP_003032153.1	Rgg/GadR/MutR family transcriptional regulator	-

Sequence

Protein

• Length: 229 a.a.
• Molecular weight: 26444.50 Da
• Isoelectric Point: 6.2732

>NTDB_id=69986 SA27298_RS06995 WP_018543712.1 1433828..1434517(-) (covR) [Streptococcus anginosus strain CCUG 27928]
MAKRILLVEKEKKLAQFIGLELQKEGYRVDLFETGKDALASARANQYDLFLLNFMLDDMTGTEFAAQLSVIKPASVIIVL
DNRDNILQYTEEIQRFAVAYMVEPFIVTDLVEKISAIFRGRDFIDQHCSQMKVPTSYRNLRIDVQNHTVYRGEEVIALTR
REYDLLATLMGSHQALSREQLLERVWKYEGAVETNVVDVYIRYLRSKIDIAGQKSYIKTVRGVGYAMQE

Nucleotide

• Length: 690 bp

>NTDB_id=69986 SA27298_RS06995 WP_018543712.1 1433828..1434517(-) (covR) [Streptococcus anginosus strain CCUG 27928]
ATGGCGAAGCGGATTTTATTAGTTGAGAAAGAAAAAAAATTAGCGCAATTTATTGGCTTAGAATTACAAAAAGAAGGTTA
TCGGGTTGATCTTTTCGAAACGGGAAAAGATGCTTTGGCGTCTGCGAGAGCTAATCAATACGATTTATTCCTGTTGAATT
TTATGCTTGACGATATGACAGGAACAGAATTTGCCGCACAATTAAGTGTGATAAAGCCTGCTTCGGTCATCATTGTATTG
GATAATCGTGATAATATTCTTCAATATACTGAGGAAATCCAACGCTTTGCTGTTGCTTACATGGTAGAACCATTCATTGT
GACGGACTTAGTTGAAAAAATTTCTGCCATTTTTCGTGGGCGTGATTTTATTGACCAGCATTGTAGTCAGATGAAAGTTC
CAACATCTTATCGGAATCTTCGGATTGATGTGCAAAATCATACAGTTTATCGAGGTGAAGAAGTGATTGCTTTGACTCGA
AGAGAGTATGATTTATTAGCAACATTGATGGGAAGTCATCAGGCTTTAAGCCGTGAACAGTTGTTAGAACGCGTGTGGAA
ATACGAAGGAGCTGTTGAAACAAATGTTGTCGATGTTTATATTCGCTATCTTCGTAGTAAAATTGATATAGCGGGGCAAA
AAAGTTATATAAAAACCGTGCGTGGTGTTGGTTATGCTATGCAAGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-114)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-227)

3D structure

• AlphaFold DB: A0A3E5D5Y8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Streptococcus salivarius strain HSISS4	48.261	100	0.485
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.415	100	0.454