Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SR187_RS07630 Genome accession   NZ_AP018400
Coordinates   1607446..1608135 (-) Length   229 a.a.
NCBI ID   WP_024532842.1    Uniprot ID   A0A2Z5TS70
Organism   Streptococcus ruminantium strain GUT-187     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1602446..1613135
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SR187_RS07605 (SR187_7785) - 1602538..1603251 (-) 714 WP_162496992.1 nitroreductase family protein -
  SR187_RS07610 (SR187_7790) dnaI 1603248..1604147 (-) 900 WP_024532838.1 primosomal protein DnaI -
  SR187_RS07615 (SR187_7795) - 1604147..1605295 (-) 1149 WP_120172052.1 replication initiation/membrane attachment protein -
  SR187_RS07620 (SR187_7800) nrdR 1605300..1605773 (-) 474 WP_024532840.1 transcriptional regulator NrdR -
  SR187_RS07625 (SR187_7805) - 1605846..1606976 (-) 1131 WP_024532841.1 AI-2E family transporter -
  SR187_RS07630 (SR187_7810) covR 1607446..1608135 (-) 690 WP_024532842.1 DNA-binding response regulator Regulator
  SR187_RS07635 (SR187_7815) gndA 1608567..1609994 (-) 1428 WP_024532843.1 NADP-dependent phosphogluconate dehydrogenase -
  SR187_RS07640 (SR187_7825) - 1610285..1610833 (-) 549 WP_120172053.1 DUF177 domain-containing protein -
  SR187_RS07645 (SR187_7830) trxB 1610843..1611760 (-) 918 WP_120172054.1 thioredoxin-disulfide reductase -
  SR187_RS07650 (SR187_7835) - 1611774..1611998 (-) 225 WP_120172055.1 DUF4059 family protein -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26184.11 Da        Isoelectric Point: 5.9622

>NTDB_id=69459 SR187_RS07630 WP_024532842.1 1607446..1608135(-) (covR) [Streptococcus ruminantium strain GUT-187]
MAKKILIAGKERNLSHFVSMELQKKDYLVDYVSTGKEALSLAHETDFDLILMSFQLSDMSSKELAKELLAMKPATVMIVA
MDPADVSQHGEEVLAYAVSYVVKPFVISDLVEQISAIFRGRDFIDNHCKQVHLHAAYRDLKVDFQNRTVTRGDELINLTR
REYDLLATLMNSPEAVSREQLLERVWKYEAASETNVVDVYIRYLRGKLDLPNQESYIKTVRGVGYAMRD

Nucleotide


Download         Length: 690 bp        

>NTDB_id=69459 SR187_RS07630 WP_024532842.1 1607446..1608135(-) (covR) [Streptococcus ruminantium strain GUT-187]
ATGGCTAAGAAAATTTTGATTGCTGGAAAAGAGCGCAATCTATCGCATTTTGTTTCTATGGAATTGCAAAAAAAGGATTA
CCTTGTGGACTATGTGTCAACCGGAAAGGAAGCCCTGTCTTTGGCTCATGAAACAGATTTTGACTTAATTCTGATGAGTT
TTCAGCTATCAGATATGTCTAGTAAGGAATTAGCCAAGGAGTTACTGGCAATGAAGCCTGCAACGGTCATGATTGTAGCA
ATGGATCCTGCGGATGTGTCCCAGCATGGCGAGGAAGTATTGGCCTATGCTGTATCCTATGTGGTGAAACCTTTTGTTAT
CAGTGACTTGGTGGAGCAAATTTCCGCTATTTTTCGTGGTCGAGACTTTATTGATAATCACTGCAAGCAGGTTCATTTGC
ACGCTGCTTATCGGGATTTAAAGGTTGATTTTCAAAATCGGACGGTAACGCGTGGGGATGAGTTAATCAATCTAACCCGC
CGTGAATACGATTTACTAGCAACCTTGATGAATAGTCCTGAAGCGGTCAGTCGGGAGCAGCTCTTAGAGCGAGTTTGGAA
ATATGAAGCTGCCTCTGAAACGAATGTAGTAGATGTTTATATTCGTTATTTACGAGGGAAATTAGACTTACCCAATCAGG
AGTCTTATATCAAAACAGTTCGCGGTGTCGGCTATGCCATGCGTGATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(155-227)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TS70

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

48.305

100

0.498
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.913

100

0.441

Multiple sequence alignment