Detailed information NTG0069458

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SR187_RS07365
• Genome accession: NZ_AP018400
• Coordinates: 1561873..1562922 (-)
• Length: 349 a.a.
• NCBI ID: WP_120172020.1
• Uniprot ID: A0A2Z5TXF1
• Organism: Streptococcus ruminantium strain GUT-187
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1556873..1567922

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SR187_RS07345 (SR187_7525)	nadE	1557856..1558680 (+)	825	WP_024533154.1	ammonia-dependent NAD(+) synthetase	-
SR187_RS07350 (SR187_7530)	-	1559450..1559968 (-)	519	WP_120172018.1	VanZ family protein	-
SR187_RS07355 (SR187_7535)	rlmN	1559965..1561077 (-)	1113	WP_120172019.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SR187_RS07360 (SR187_7540)	-	1561086..1561742 (-)	657	WP_024533151.1	YutD-like domain-containing protein	-
SR187_RS07365 (SR187_7545)	sepM	1561873..1562922 (-)	1050	WP_120172020.1	SepM family pheromone-processing serine protease	Regulator
SR187_RS07370 (SR187_7550)	coaD	1562909..1563397 (-)	489	WP_024533097.1	pantetheine-phosphate adenylyltransferase	-
SR187_RS07375 (SR187_7555)	rsmD	1563387..1563926 (-)	540	WP_120172021.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SR187_RS07380 (SR187_7560)	-	1564403..1565128 (-)	726	WP_120172022.1	serine protease	-
SR187_RS07385 (SR187_7565)	-	1565186..1565572 (-)	387	WP_120172023.1	rhodanese-like domain-containing protein	-
SR187_RS07390 (SR187_7570)	-	1565572..1565790 (-)	219	WP_024533101.1	YqgQ family protein	-
SR187_RS07395 (SR187_7580)	-	1566102..1566704 (-)	603	WP_120172024.1	response regulator transcription factor	-
SR187_RS07400 (SR187_7585)	-	1566701..1567765 (-)	1065	WP_120172025.1	sensor histidine kinase	-

Sequence

Protein

• Length: 349 a.a.
• Molecular weight: 37559.74 Da
• Isoelectric Point: 4.7927

>NTDB_id=69458 SR187_RS07365 WP_120172020.1 1561873..1562922(-) (sepM) [Streptococcus ruminantium strain GUT-187]
MKKNRKLLLITSIVLGTLLIWFTVFVPLPYYLESPGGAADIRQVLTVNNQVDEKEGSYNFTYVSVQQATALQLLAAQFDP
HTSVRSAEEMAGGANSAEYFRIARFYMETSQNMAKYQGLTLAGKEANMKFFGVYVLNLAEDSTFKSILNIADTVVSINGK
TFESSPDLIKYVSGLELGSDVTVGYISDGEEKSAKGKIIKLANGKNGIGIGLVDHTEVQSSVPIDFQTGNIGGPSAGLMF
TLAIYTQLADPDLRDGRMIAGTGTIEKDGKVGDIGGADKKVLSAAKAGASIFFVPNNPVDEAILKLNPNAKTNYEEAKES
AEKAAVDIEIVPVQTVQDAIDYLKKTKSE

Nucleotide

• Length: 1050 bp

>NTDB_id=69458 SR187_RS07365 WP_120172020.1 1561873..1562922(-) (sepM) [Streptococcus ruminantium strain GUT-187]
ATGAAAAAAAATAGAAAACTACTCTTAATCACATCCATTGTTTTAGGAACTCTTTTGATTTGGTTTACTGTCTTTGTTCC
CCTACCTTATTATCTAGAAAGTCCTGGAGGAGCTGCTGATATTCGTCAAGTATTAACAGTAAATAATCAAGTAGACGAGA
AAGAGGGATCTTACAATTTTACTTATGTGTCTGTTCAGCAAGCTACAGCTTTGCAACTGTTAGCAGCCCAGTTTGACCCG
CATACAAGTGTGCGATCAGCCGAAGAGATGGCAGGTGGTGCCAATAGTGCAGAGTACTTCCGTATCGCTCGCTTCTACAT
GGAAACTTCACAGAATATGGCCAAATACCAAGGATTAACCTTGGCAGGAAAAGAAGCGAATATGAAGTTCTTTGGCGTAT
ATGTTCTCAACTTGGCAGAAGATTCTACTTTTAAAAGTATTCTTAATATTGCTGATACAGTTGTTAGTATCAACGGAAAA
ACCTTTGAATCATCACCAGATTTAATCAAGTATGTTAGTGGTTTAGAATTGGGCAGTGATGTTACAGTTGGCTATATCAG
CGATGGGGAAGAAAAATCGGCCAAGGGTAAGATTATTAAATTAGCTAATGGTAAGAATGGTATTGGAATTGGTCTTGTTG
ACCATACGGAGGTTCAAAGCTCAGTTCCAATTGATTTCCAAACAGGTAATATAGGTGGACCAAGTGCAGGACTGATGTTC
ACTTTAGCTATCTATACTCAATTGGCAGATCCTGATTTGCGCGATGGACGGATGATTGCAGGAACGGGTACCATAGAAAA
AGATGGTAAGGTTGGAGATATTGGTGGAGCAGATAAAAAGGTTTTATCAGCAGCTAAAGCGGGAGCAAGTATCTTCTTTG
TCCCAAATAATCCAGTTGATGAAGCCATTTTGAAGCTGAATCCAAATGCCAAAACTAATTATGAAGAAGCGAAAGAATCG
GCTGAGAAGGCGGCTGTGGATATTGAGATTGTCCCTGTCCAGACTGTTCAAGACGCTATTGATTATCTTAAGAAGACAAA
GAGCGAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (132-195)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (232-298)

3D structure

• AlphaFold DB: A0A2Z5TXF1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	60.519	99.427	0.602